DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and ADAM18

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_055052.1	Gene:	ADAM18 / 8749	HGNCID:	196	Length:	739	Species:	Homo sapiens

Alignment Length:	679	Identity:	188/679 - (27%)
Similarity:	280/679 - (41%)	Gaps:	137/679 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 LELNSQLLSPNIQQKHYHVGGYLVDGNRHDIE-----HCYYHGTVKDYPGASAAFHTCNGVSGVI 189
            |.|..|...|    :::.|..|...|:.|.:.     ||:|.|...::|.:......|:|:.|.:
Human    58 LHLGKQSFLP----QNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFL 118

  Fly   190 HIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLD--------SWR--------LSRR 238
            ...|.::.|.|....  ::..|:|::.:.       |..|:.        .|:        |:.:
Human   119 QFENISYGIEPVESS--ARFEHIIYQMKN-------NDPNVSILAVNYSHIWQKDQPYKVPLNSQ 174

  Fly   239 TKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVAN 303
            .|:||                      :...:|:|..|||:||::|.. ||....|....:||..
Human   175 IKNLS----------------------KLLPQYLEIYIIVEKALYDYM-GSEMMAVTQKIVQVIG 216

  Fly   304 IADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLL----- 363
            :.:..|......|.:..:|.| .|:..|..|.|....:..|..:....|.....|...||
Human   217 LVNTMFTQFKLTVILSSLELW-SNENQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKH 280

  Fly   364 ---TGETFAGG------EAGMAVPETVCTPRAVGI---SVDVNVYEPHLLAGTMAHMIGHNIGMG 416
               .|.||.|.      :||:|:     .|.|:|:   ||            .:|.::|.|:|:.
Human   281 PKYVGATFPGTVCNKSYDAGIAM-----YPDAIGLEGFSV------------IIAQLLGLNVGLT 328

  Fly   417 HDDGREECFCRDWHGCIMAQSIVGQENVQPYK---FSECSKKDYIDALRTGHGLCLLNKPNEIEL 478
            :|| ..:||      |:.|..|:..|.|....   ||.||..||...:......||....|...|
Human   329 YDD-ITQCF------CLRATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPL 386

  Fly   479 RRN---CGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACC-DQCRLRPKDYICR 539
            .:|   |||.::|.:||||||...||...:|||..|||||...:|.||.|| .:|.|......||
Human   387 HQNQPVCGNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCR 451

  Fly   540 DS-NNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSA 603
            .| :.|||..|||:|....|..|.:..||..|.|.    :.||:.|.|.|...||..|:|.|...
Human   452 KSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLG----TAYCYNGQCQTTDNQCAKIFGKGAQG 512

  Fly   604 ADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQC----KDGERQPVNDGIDQLYS-- 662
            |...|:::.||....:.:|| ..|...:.||.::|.||.|.|    |:..:   :|....:||
Human   513 APFACFKEVNSLHERSENCG-FKNSQPLPCERKDVLCGKLACVQPHKNANK---SDAQSTVYSYI 573

  Fly   663 --RTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPAN 725
              ...:||        ||...:.|:. .::..|.|||.||..:.|:|:||..:  |:....|.|.
Human   574 QDHVCVSI--------ATGSSMRSDG-TDNAYVADGTMCGPEMYCVNKTCRKV--HLMGYNCNAT 627

  Fly   726 SQGLECSEHGVCTNTNRCFCDMGWGGNDC 754
            :   :|...|:|.|...|.|..|....||
Human   628 T---KCKGKGICNNFGNCQCFPGHRPPDC 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	20/87 (23%)
		Reprolysin	270..473	CDD:279729	59/222 (27%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	59/220 (27%)
		Disintegrin	488..562	CDD:278623	35/75 (47%)
		ACR	566..713	CDD:214743	47/154 (31%)
ADAM18	NP_055052.1	Pep_M12B_propep	26..141	CDD:307618	20/88 (23%)
		Reprolysin	184..380	CDD:307535	59/221 (27%)
		DISIN	399..476	CDD:214490	36/76 (47%)
		ACR	478..617	CDD:214743	47/155 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146043
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850