Protein Alignment mmd and ADAM20

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: XP_005268208.1
• Gene: ADAM20 / 8748
• HGNCID: 199
• Length: 776
• Species: Homo sapiens
• Alignment Length: 749
• Identity: 203/749 - (27%)
• Similarity: 343/749 - (45%)
• Gaps: 108/749 - (14%)

  Fly   104 NRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGT 168
            :|||..|.....|..::....::.:.:.:|..|.:.::....|.....|:.......:.|||||.
Human   100 SRGRGAKAPGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGY 164

  Fly   169 VKDYPGASAAFHTCN-GVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDS 232
            |:..|.:..|..||: |..|::.|.:..:.|.|.  ...:...|::::..:...:.......|..
Human   165 VEGVPESLVALSTCSGGFLGMLQINDLVYEIKPI--SVSATFEHLVYKIDSDDTQFPPMRCGLTE 227

  Fly   233 WRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVD--KAMFDKRNGSTRAEVI 295
            .:::.:.: |.......:::....|...::|       ::|..::||  :.:|.:.|.:|   |.
Human   228 EKIAHQME-LQLSYNFTLKQSSFVGWWTHQR-------FVELVVVVDNIRYLFSQSNATT---VQ 281

  Fly   296 HDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDT 359
            |:...|.||.|.::..|...|.:..|:.|..:.. :..|.|:...:.:|:.:.:.|| .:::.|.
Human   282 HEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNP-LPTSGDLDNVLEDFSIWKNYNLNNRLQHDV 345

  Fly   360 TQLLTGETFAGGEAGMAVPETVC-TPRAVGISVDVNVYEPHLL---AGTMAHMIGHNIGMGHDDG 420
            ..|...:| .|.:.|:|..:.:| .|...|    |:|:|.:.|   |.|:.|.:|||:||.||
Human   346 AHLFIKDT-QGMKLGVAYVKGICQNPFNTG----VDVFEDNRLVVFAITLGHELGHNLGMQHD-- 403

  Fly   421 REECFCR-DWHGCIMAQSIVGQENVQPY-----KFSECSKKDYIDALRTGHGLCLLNK--PNEIE 477
            .:.|.|. .|  |||          ..|     |||.||...|.|: ....|||:...  |..|.
Human   404 TQWCVCELQW--CIM----------HAYRKVTTKFSNCSYAQYWDS-TISSGLCIQPPPYPGNIF 455

  Fly   478 LRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSN 542
            ..:.|||.||||.|||||||..:||.|.|| .:.|.|...|.||.|.||..|:..|...:||...
Human   456 RLKYCGNLVVEEGEECDCGTIRQCAKDPCC-LLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQV 519

  Fly   543 NECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQ 607
            .||||||:|:|...|||.||:.::|..|     .::.:|::..|....:||:.|:|....:|.:.
Human   520 GECDLPEWCNGTSHQCPDDVYVQDGISC-----NVNAFCYEKTCNNHDIQCKEIFGQDARSASQS 579

  Fly   608 CYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGI--DQLYSRTIISIKG 670
            ||::.|::|:..|||| .....|:||...::.||.:||:       |.|:  :.:...|:.....
Human   580 CYQEINTQGNRFGHCG-IVGTTYVKCWTPDIMCGRVQCE-------NVGVIPNLIEHSTVQQFHL 636

  Fly   671 QEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHG 735
            .:..|..|...:|. :.|:.|.|||||.||...||:.:.|.|:. |:.|...|..     |:..|
Human   637 NDTTCWGTDYHLGM-AIPDIGEVKDGTVCGPEKICIRKKCASMV-HLSQACQPKT-----CNMRG 694

  Fly   736 VCTNTNRCFC----------DMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQ 790
            :|.|...|.|          |.|:||:             .::.|.|:|.::        |.:..
Human   695 ICNNKQHCHCNHEWAPPYCKDKGYGGS-------------ADSGPPPKNNME--------GLNVM 738

  Fly   791 NRISTLTMVIILTVIVKCVFISFATLAVCYRRKT 824
            .::..|:::.:|.::   .|:.|. |.|.::::|
Human   739 GKLRYLSLLCLLPLV---AFLLFC-LHVLFKKRT 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	25/110 (23%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	61/213 (29%)
		Disintegrin	488..561	CDD:459709	37/72 (51%)
		ACR	566..713	CDD:214743	42/148 (28%)
ADAM20	XP_005268208.1	Pep_M12B_propep	91..209	CDD:460254	25/110 (23%)
		ZnMc_adamalysin_II_like	257..446	CDD:239797	62/219 (28%)
		Disintegrin	466..538	CDD:459709	37/72 (51%)
		ACR	542..678	CDD:214743	42/149 (28%)