DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and ADAM20

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_005268208.1	Gene:	ADAM20 / 8748	HGNCID:	199	Length:	776	Species:	Homo sapiens

Alignment Length:	749	Identity:	203/749 - (27%)
Similarity:	343/749 - (45%)	Gaps:	108/749 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 NRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGT 168
            :|||..|.....|..::....::.:.:.:|..|.:.::....|.....|:.......:.|||||.
Human   100 SRGRGAKAPGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGY 164

  Fly   169 VKDYPGASAAFHTCN-GVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDS 232
            |:..|.:..|..||: |..|::.|.:..:.|.|.  ...:...|::::..:...:.......|..
Human   165 VEGVPESLVALSTCSGGFLGMLQINDLVYEIKPI--SVSATFEHLVYKIDSDDTQFPPMRCGLTE 227

  Fly   233 WRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVD--KAMFDKRNGSTRAEVI 295
            .:::.:.: |.......:::....|...::|       ::|..::||  :.:|.:.|.:|   |.
Human   228 EKIAHQME-LQLSYNFTLKQSSFVGWWTHQR-------FVELVVVVDNIRYLFSQSNATT---VQ 281

  Fly   296 HDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDT 359
            |:...|.||.|.::..|...|.:..|:.|..:.. :..|.|:...:.:|:.:.:.|| .:::.|.
Human   282 HEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNP-LPTSGDLDNVLEDFSIWKNYNLNNRLQHDV 345

  Fly   360 TQLLTGETFAGGEAGMAVPETVC-TPRAVGISVDVNVYEPHLL---AGTMAHMIGHNIGMGHDDG 420
            ..|...:| .|.:.|:|..:.:| .|...|    |:|:|.:.|   |.|:.|.:|||:||.||
Human   346 AHLFIKDT-QGMKLGVAYVKGICQNPFNTG----VDVFEDNRLVVFAITLGHELGHNLGMQHD-- 403

  Fly   421 REECFCR-DWHGCIMAQSIVGQENVQPY-----KFSECSKKDYIDALRTGHGLCLLNK--PNEIE 477
            .:.|.|. .|  |||          ..|     |||.||...|.|: ....|||:...  |..|.
Human   404 TQWCVCELQW--CIM----------HAYRKVTTKFSNCSYAQYWDS-TISSGLCIQPPPYPGNIF 455

  Fly   478 LRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSN 542
            ..:.|||.||||.|||||||..:||.|.|| .:.|.|...|.||.|.||..|:..|...:||...
Human   456 RLKYCGNLVVEEGEECDCGTIRQCAKDPCC-LLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQV 519

  Fly   543 NECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQ 607
            .||||||:|:|...|||.||:.::|..|     .::.:|::..|....:||:.|:|....:|.:.
Human   520 GECDLPEWCNGTSHQCPDDVYVQDGISC-----NVNAFCYEKTCNNHDIQCKEIFGQDARSASQS 579

  Fly   608 CYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGI--DQLYSRTIISIKG 670
            ||::.|::|:..|||| .....|:||...::.||.:||:       |.|:  :.:...|:.....
Human   580 CYQEINTQGNRFGHCG-IVGTTYVKCWTPDIMCGRVQCE-------NVGVIPNLIEHSTVQQFHL 636

  Fly   671 QEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHG 735
            .:..|..|...:|. :.|:.|.|||||.||...||:.:.|.|:. |:.|...|..     |:..|
Human   637 NDTTCWGTDYHLGM-AIPDIGEVKDGTVCGPEKICIRKKCASMV-HLSQACQPKT-----CNMRG 694

  Fly   736 VCTNTNRCFC----------DMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQ 790
            :|.|...|.|          |.|:||:             .::.|.|:|.::        |.:..
Human   695 ICNNKQHCHCNHEWAPPYCKDKGYGGS-------------ADSGPPPKNNME--------GLNVM 738

  Fly   791 NRISTLTMVIILTVIVKCVFISFATLAVCYRRKT 824
            .::..|:::.:|.::   .|:.|. |.|.::::|
Human   739 GKLRYLSLLCLLPLV---AFLLFC-LHVLFKKRT 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	24/107 (22%)
		Reprolysin	270..473	CDD:279729	61/217 (28%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	61/213 (29%)
		Disintegrin	488..562	CDD:278623	37/73 (51%)
		ACR	566..713	CDD:214743	42/148 (28%)
ADAM20	XP_005268208.1	Pep_M12B_propep	100..208	CDD:279848	25/109 (23%)
		Reprolysin	257..449	CDD:279729	62/222 (28%)
		ZnMc_adamalysin_II_like	257..446	CDD:239797	62/219 (28%)
		Disintegrin	466..539	CDD:278623	37/73 (51%)
		ACR	542..678	CDD:214743	42/149 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146061
Domainoid	1	1.000	104	1.000	Domainoid score	I6691
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850