DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and ADAM19

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_150377.1	Gene:	ADAM19 / 8728	HGNCID:	197	Length:	918	Species:	Homo sapiens

Alignment Length:	724	Identity:	225/724 - (31%)
Similarity:	339/724 - (46%)	Gaps:	122/724 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 RPRPHDDSGFNRGR-----------------------TKKHFHRTSLLIKAFNHKFRLDLELNSQ 135
            |||...:.|:.||.                       .:||..:..|.:.|...:..||||.|.|
Human    21 RPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAELRVMAEGRELILDLEKNEQ 85

  Fly   136 LLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHI-GNETFVIH 199
            |.:|:..:.||...|......|...:||:|||||::...:|....||.|:.|:|.: .|.::||.
Human    86 LFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIE 150

  Fly   200 PFYGGDLSKHPHVIFEAR----TKANKGCANS-GNLDSWRL--SRRTKHLSAGVAGVVEEILQAG 257
            |...   ||..|:|:.:.    ...|.|..:| .....|.|  :::||....
Human   151 PLPD---SKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPR------------- 199

  Fly   258 VGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIE 322
              |.||:...:.||:|..::.|...|.| |...:....|..|::||..|.::|:||.|:::|.:|
Human   200 --RMKREDLNSMKYVELYLVADYLEFQK-NRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLE 261

  Fly   323 TWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTP-RA 386
            .|.... :.:.|::....:.:|..:..:.|.|...|..||:||.:|.|...|:|....:|:. ::
Human   262 VWTHGN-MCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQS 325

  Fly   387 VGISVDVNVYEPHL-----LAGTMAHMIGHNIGMGHD----------DGREECFCRDWHGCIMAQ 436
            .|:::|      |.     :|.||||.:|||.||.||          ||          |||||
Human   326 GGVNMD------HSENAIGVAATMAHEMGHNFGMTHDSADCCSASAADG----------GCIMA- 373

  Fly   437 SIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIEL--RRNCGNKVVEEDEECDCGTFE 499
              ....:..|..|:.|::::....|::|.|:||.|.|:...|  .|.|||..:|:.||||||..|
Human   374 --AATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEE 436

  Fly   500 ECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFK 564
            ||. :.||:...|.|:..|:||.|:||.||:|.....:||:...:|||||:|.|:...||::.::
Human   437 ECN-NPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQ 500

  Fly   565 KNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEH 629
            .:|:||    .|...||:.|.|.|...||:.:||.|...|...|:|:.|..|...|:||:|.|..
Human   501 MDGTPC----EGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGE 561

  Fly   630 YIKCEPENVQCGTLQCKDGERQPVNDG---IDQLYSRTIISIKGQEFECKATSGQVGSNSYPEH- 690
            :.||...:.:||.:||:..|.:|:...   ||     |.|.:.|::.:|:.|....|    ||.
Human   562 HRKCNMRDAKCGKIQCQSSEARPLESNAVPID-----TTIIMNGRQIQCRGTHVYRG----PEEE 617

  Fly   691 ------GLVKDGTPCGDNLICLNQTC--VSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDM 747
                  |||..||.||.|.||....|  .|.|   :...|     |.:|:.||||.|...|.|..
Human   618 GDMLDPGLVMTGTKCGYNHICFEGQCRNTSFF---ETEGC-----GKKCNGHGVCNNNQNCHCLP 674

  Fly   748 GWGGNDCSS 756
            ||....|::
Human   675 GWAPPFCNT 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	37/130 (28%)
		Reprolysin	270..473	CDD:279729	64/218 (29%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	63/216 (29%)
		Disintegrin	488..562	CDD:278623	34/73 (47%)
		ACR	566..713	CDD:214743	53/158 (34%)
ADAM19	NP_150377.1	Pep_M12B_propep	58..161	CDD:279848	36/105 (34%)
		Cysteine switch. /evidence=ECO:0000250	130..137		3/6 (50%)
		Reprolysin	210..408	CDD:279729	64/218 (29%)
		ZnMc_adamalysin_II_like	210..406	CDD:239797	63/216 (29%)
		DISIN	439..499	CDD:214490	24/60 (40%)
		ACR	501..646	CDD:214743	53/157 (34%)
		SH3-binding. /evidence=ECO:0000255	833..844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I7980
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920