DRSC/TRiP Functional Genomics Resources

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Protein Alignment mmd and ADAM12

DIOPT Version :10

Sequence 1:NP_001285311.1 Gene:mmd / 32561 FlyBaseID:FBgn0259110 Length:1484 Species:Drosophila melanogaster
Sequence 2:NP_003465.3 Gene:ADAM12 / 8038 HGNCID:190 Length:909 Species:Homo sapiens


Alignment Length:781 Identity:247/781 - (31%)
Similarity:376/781 - (48%) Gaps:117/781 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 TKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIE----------H 162
            :|.|....::.::..:.:..::||.|..|::.:..:.|     ||.||.  |:.          |
Human    61 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETH-----YLQDGT--DVSLARNYTVILGH 118

  Fly   163 CYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEA-RTKANKG-CA 225
            |||||.|:.|..::.:..||:|:.|:|...||::|:.|...   :.:.:.:|.| :.|:.:| |.
Human   119 CYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKS---ATNRYKLFPAKKLKSVRGSCG 180

  Fly   226 NSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGST 290
            :..|         |.:|:|  ..|.....|....|:||:..:||||:|..|:.|...| :|.|..
Human   181 SHHN---------TPNLAA--KNVFPPPSQTWARRHKRETLKATKYVELVIVADNREF-QRQGKD 233

  Fly   291 RAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLF-Q 354
            ..:|....|::||..|.::|.||.|:.:|.:|.| .:......|:|...::..|.|:....|. :
Human   234 LEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVW-NDMDKCSVSQDPFTSLHEFLDWRKMKLLPR 297

  Fly   355 IERDTTQLLTGETFAGGEAGMAVPETVCT-PRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHD 418
            ...|..||::|..|.|...|||...::|| .::.||.:| :...|...|.|:||.:|||.||.||
Human   298 KSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMD-HSDNPLGAAVTLAHELGHNFGMNHD 361

  Fly   419 DGREECFCR---DWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELR- 479
            .....|.|:   :..||||..| .|..  .|..||.||:||...:|..|.|:||.|.|   |:| 
Human   362 TLDRGCSCQMAVEKGGCIMNAS-TGYP--FPMVFSSCSRKDLETSLEKGMGVCLFNLP---EVRE 420

  Fly   480 ----RNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRD 540
                :.|||:.|||.||||||..||| :::||:..||.||.:|.||.|.||:.|:|:|....|||
Human   421 SFGGQKCGNRFVEEGEECDCGEPEEC-MNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRD 484

  Fly   541 SNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAAD 605
            |:|.|||||:|.|....||::|:..:|..|    ..:.|||:.|.|.|...||..:||.|...|.
Human   485 SSNSCDLPEFCTGASPHCPANVYLHDGHSC----QDVDGYCYNGICQTHEQQCVTLWGPGAKPAP 545

  Fly   606 RQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISI-K 669
            ..|:|:.||.|...|:||:.:...:.|||..:.:||.:||:.|..:|| .|.:.:...|.|.: :
Human   546 GICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPV-IGTNAVSIETNIPLQQ 609

  Fly   670 GQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTC--VSLFPHVDQTKCPANSQGLECS 732
            |....|:.|...:| :..|:.|||..||.|.|..||||:.|  :|:|        ..:...::|.
Human   610 GGRILCRGTHVYLG-DDMPDPGLVLAGTKCADGKICLNRQCQNISVF--------GVHECAMQCH 665

  Fly   733 EHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRI---- 793
            ..|||.|...|.|:..|....|.                         |....|::|...|    
Human   666 GRGVCNNRKNCHCEAHWAPPFCD-------------------------KFGFGGSTDSGPIRQAD 705

  Fly   794 -STLTMVIILTVIVKC-------VFISFATL-AVCYRRKTTTLK-------YDPPYSKKPIAKSY 842
             ..||:.|::|::  |       |::...|| .:.:..|.||::       ..||...:|.....
Human   706 NQGLTIGILVTIL--CLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHL 768

  Fly   843 G 843
            |
Human   769 G 769

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mmdNP_001285311.1 Pep_M12B_propep 104..214 CDD:460254 29/115 (25%)
ZnMc_adamalysin_II_like 270..471 CDD:239797 71/205 (35%)
Disintegrin 488..561 CDD:459709 40/72 (56%)
ACR 566..713 CDD:214743 52/149 (35%)
ADAM12NP_003465.3 Pep_M12B_propep 60..159 CDD:460254 29/104 (28%)
Cysteine switch. /evidence=ECO:0000250 177..184 2/6 (33%)
Reprolysin 214..416 CDD:426256 72/207 (35%)
DISIN 439..507 CDD:214490 35/68 (51%)
ACR 510..652 CDD:214743 52/147 (35%)
PHA03247 <754..905 CDD:223021 4/16 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..862
SH3-binding, class II. /evidence=ECO:0000250 828..834
SH3-binding, class I. /evidence=ECO:0000250 834..841
SH3-binding, class I. /evidence=ECO:0000250 885..891
Blue background indicates that the domain is not in the aligned region.

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