DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and ADAM33

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_005260900.1	Gene:	ADAM33 / 80332	HGNCID:	15478	Length:	826	Species:	Homo sapiens

Alignment Length:	845	Identity:	247/845 - (29%)
Similarity:	364/845 - (43%)	Gaps:	191/845 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 REVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHV 148
            |.|||.:|..:|    |.|.             :.::|...:..|:||.|.:||:|...:.||..
Human    52 RTVSLEEPVSKP----DMGL-------------VALEAEGQELLLELEKNHRLLAPGYIETHYGP 99

  Fly   149 GGY-LVDGNRHDI------------EHCYYHGTVKDYPGASAAFHTCNGVSGVIHIG-NETFVIH 199
            .|. :|....|.:            :||:|.|.|:.:|.:.....||:|:||:|.:. |.::.:.
Human   100 DGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLR 164

  Fly   200 PF-YGGDLSKHPHVIFEART----KANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAG-V 258
            |: ..|......|.||....    |...|..:.||             .||:..     |..| .
Human   165 PWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGN-------------KAGMTS-----LPGGPQ 211

  Fly   259 GRNKRDVREATKYIETAIIVDKAMFDKRN---GSTRAEVIHDAIQVANIADLYFRTLNTRVSVVY 320
            .|.:|:.|...||:|..|:.|..:|..|:   ..|:..:    ::|||..|...|||:.:|::..
Human   212 SRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRL----LEVANYVDQLLRTLDIQVALTG 272

  Fly   321 IETWGKNQAVIDGSK---DISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVC 382
            :|.|.:.    |.|:   |.:..:..|..:......|...|:.|||||..|.|...|:|..|.:|
Human   273 LEVWTER----DRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMC 333

  Fly   383 TPRAV-GISVDVNVYEPHLLAGTMAHMIGHNIGMGHD-DGREECFC----RDWHGCIMAQSIVGQ 441
            ...:. |:|.|.:.. |...|.||||.|||::|:.|| ||   | |    .:..||:||   ...
Human   334 RAESSGGVSTDHSEL-PIGAAATMAHEIGHSLGLSHDPDG---C-CVEAAAESGGCVMA---AAT 390

  Fly   442 ENVQPYKFSECSKKDYIDALRTGHGLCLLNKPN-----EIELRRNCGNKVVEEDEECDCGTFEEC 501
            .:..|..||.||::......|.|.|.||.|.|:     ...|   |||..||..||||||..:||
Human   391 GHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPAL---CGNGFVEAGEECDCGPGQEC 452

  Fly   502 ALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKN 566
            . |.||....|.|:..||||.|.||.:|.|:|...:||.:..:|||||:|.|....||.||:..:
Human   453 R-DLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLD 516

  Fly   567 GSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYI 631
            ||||...    ||||:.|.||||..||:.:||.|...|...|::..||.|..:|:||:|:..|::
Human   517 GSPCARG----SGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFL 577

  Fly   632 KCEPENVQCGTLQCKDGERQ-------PVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPE 689
            .|...:..||.|||:.|:..       ||:         :.:.:.|||..|:      |:.:.|.
Human   578 PCAGRDALCGKLQCQGGKPSLLAPHMVPVD---------STVHLDGQEVTCR------GALALPS 627

  Fly   690 H-------GLVKDGTPCGDNLICLNQTC-VSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCD 746
            .       |||:.||.||..::|.::.| .:.|..:.  :|..     .|..||||.:.:.|.|.
Human   628 AQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQ--RCLT-----ACHSHGVCNSNHNCHCA 685

  Fly   747 MGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRI-----STLTMVIILTVIV 806
            .||....|.                         |....|:.|...:     .|..:.::|:|::
Human   686 PGWAPPFCD-------------------------KPGFGGSMDSGPVQAENHDTFLLAMLLSVLL 725

  Fly   807 KCVFISFATLA-VCYR-------RKTTTLKYDP--------PYSKKPIAKSYGGAATAPNHHSVE 855
            .  .:..|.|| .|||       |.:...:.||        |:...|:    ||.      |.:|
Human   726 P--LLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPL----GGV------HPME 778

Fly 856 855
Human 779 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	29/121 (24%)
		Reprolysin	270..473	CDD:279729	69/214 (32%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	68/212 (32%)
		Disintegrin	488..562	CDD:278623	35/73 (48%)
		ACR	566..713	CDD:214743	52/161 (32%)
ADAM33	XP_005260900.1	Pep_M12B_propep	<83..177	CDD:279848	24/93 (26%)
		Reprolysin	223..422	CDD:279729	69/214 (32%)
		ZnMc_adamalysin_II_like	223..420	CDD:239797	68/212 (32%)
		DISIN	439..513	CDD:214490	36/74 (49%)
		ACR	515..657	CDD:214743	52/160 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146055
Domainoid	1	1.000	87	1.000	Domainoid score	I7980
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850