Protein Alignment mmd and adam15

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: XP_001335318.4
• Gene: adam15 / 795199
• ZFINID: ZDB-GENE-070809-4
• Length: 992
• Species: Danio rerio
• Alignment Length: 782
• Identity: 254/782 - (32%)
• Similarity: 375/782 - (47%)
• Gaps: 125/782 - (15%)

  Fly   109 KKHFHRTSLLIKAFNHKFRLDLELNSQLL--SPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKD 171
            |.|..|....::..:..:.||||.|..||  .||:  .:|...|..|....:.:.||||||:|:.
Zfish    92 KGHPDRLQCGLQVGSSLYILDLEKNQDLLPKPPNV--FYYLPNGTGVSMKENTVTHCYYHGSVQG 154

  Fly   172 YPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLS 236
            :|.:..|..:|:|:.|||.| |.|........|:         |.|.|.::|   ||.::...:
Zfish   155 FPESRVALSSCSGLRGVIVI-NATLSFELLPEGE---------EERGKDDEG---SGEMEEGEM- 205

  Fly   237 RRTKHLSAGVAGVVEEILQAGVG--------------RNKRDVREATKYIETAIIVDKAMF--DK 285
                |..........|....||.              |:|||:....||||..::.|...:  .:
Zfish   206 ----HAIYSTHSPTSESRDCGVSHTSIPPIQIIPHTHRSKRDILSEIKYIELVLVADHKEYLNYQ 266

  Fly   286 RNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSR 350
            :|..|   :|:..:.|||..|.::|.||.||:::.:|.| .:|..|...|..::.::.|.|:.:|
Zfish   267 KNNKT---IIYRMLDVANQVDWFYRPLNVRVALLGLEIW-SDQDKIKVDKSPTETLNRFLDWRTR 327

  Fly   351 NLF-QIERDTTQLLTGETFAGGEAGMAVPETVCT-PRAVGISVDVNVYEPHL-----LAGTMAHM 408
            .|. ::..|..||:.||:|.|...|||...::|: .|:.|::||      ||     :|.|:||.
Zfish   328 ELLPRLRHDNAQLIMGESFDGTTVGMASQSSMCSKDRSGGVNVD------HLVSVLGVASTVAHE 386

  Fly   409 IGHNIGMGHDDGREECFCRD---WHGCIMAQS---IVGQENVQPYKFSECSKKDYIDALRTGHGL 467
            :|||:||.||.....|.|::   ..||||..|   :.||      .||.||::|...:|..|.|:
Zfish   387 LGHNLGMSHDTADRRCHCQNEPRLGGCIMEPSTGFMPGQ------LFSSCSERDLSLSLLHGGGM 445

  Fly   468 CLLNKPNEIEL--RRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCAS-GACCDQC 529
            ||.|.|....|  ...|||..||:.||||||..:||. |.||:..||||...|||:| |.||:.|
Zfish   446 CLFNVPQPESLLGGPRCGNLYVEKGEECDCGLLDECN-DPCCNASTCKLVPGAQCSSDGICCENC 509

  Fly   530 RLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCE 594
            :||....:||:...||||||:|.|....||.:||.:||.||    .|.|.||:.|.|.:|..||:
Zfish   510 KLRVAGSVCREPLGECDLPEHCTGSSPYCPPNVFLQNGEPC----KGGSSYCYSGVCASLDDQCQ 570

  Fly   595 AIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQ 659
            .:||...:.|...|:...|.:|:..|:||:..|..||.|...:|.||.:||:.|..:|:.....:
Zfish   571 MLWGQNSTRAPPICFSSVNKQGNKYGNCGQMPNGSYIPCLKWDVHCGRIQCQGGGERPLLGSNAE 635

  Fly   660 LYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTC--VSLFPHVDQTKC 722
            :.:.|:| :...:|.|:.|...:| :...:..:|..||.||.|..|::|.|  ||:| .||:.:.
Zfish   636 ILTTTVI-LNQSDFTCRGTYFNLG-DDVSDPAMVLQGTACGPNKACVDQKCRDVSMF-GVDECRS 697

  Fly   723 PANSQGLECSEHGVCTNTNRCFCDMGWGGNDC------SSVVLLTTALPTEALPTPENTIKMEKK 781
                   :|..||||.:...|.||.||...||      .||         ::.|..|..
Zfish   698 -------KCHGHGVCNSNKNCHCDEGWAPPDCRYSGNGGSV---------DSGPAQEPR------ 740

  Fly   782 ETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLAVCYRRKTTTLKY--DPPYSK----KPIAK 840
                 .||..|::.|  ||.|.|:.    :|...:|:.:.|....|.|  ..|::|    :.|..
Zfish   741 -----DSDPARVALL--VIFLFVLP----VSLLFVALRFPRCRRGLVYLGHTPFNKTRQSRGITV 794

  Fly   841 SY 842
            ||
Zfish   795 SY 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	33/106 (31%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	73/215 (34%)
		Disintegrin	488..561	CDD:459709	38/73 (52%)
		ACR	566..713	CDD:214743	49/148 (33%)
adam15	XP_001335318.4	Pep_M12B_propep	80..209	CDD:460254	40/136 (29%)
		ZnMc_adamalysin_II_like	249..449	CDD:239797	73/215 (34%)
		Disintegrin	468..541	CDD:459709	38/73 (52%)
		ACR	545..687	CDD:214743	48/147 (33%)