DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and adam15

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_001335318.4	Gene:	adam15 / 795199	ZFINID:	ZDB-GENE-070809-4	Length:	992	Species:	Danio rerio

Alignment Length:	782	Identity:	254/782 - (32%)
Similarity:	375/782 - (47%)	Gaps:	125/782 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 KKHFHRTSLLIKAFNHKFRLDLELNSQLL--SPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKD 171
            |.|..|....::..:..:.||||.|..||  .||:  .:|...|..|....:.:.||||||:|:.
Zfish    92 KGHPDRLQCGLQVGSSLYILDLEKNQDLLPKPPNV--FYYLPNGTGVSMKENTVTHCYYHGSVQG 154

  Fly   172 YPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLS 236
            :|.:..|..:|:|:.|||.| |.|........|:         |.|.|.::|   ||.::...:
Zfish   155 FPESRVALSSCSGLRGVIVI-NATLSFELLPEGE---------EERGKDDEG---SGEMEEGEM- 205

  Fly   237 RRTKHLSAGVAGVVEEILQAGVG--------------RNKRDVREATKYIETAIIVDKAMF--DK 285
                |..........|....||.              |:|||:....||||..::.|...:  .:
Zfish   206 ----HAIYSTHSPTSESRDCGVSHTSIPPIQIIPHTHRSKRDILSEIKYIELVLVADHKEYLNYQ 266

  Fly   286 RNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSR 350
            :|..|   :|:..:.|||..|.::|.||.||:::.:|.| .:|..|...|..::.::.|.|:.:|
Zfish   267 KNNKT---IIYRMLDVANQVDWFYRPLNVRVALLGLEIW-SDQDKIKVDKSPTETLNRFLDWRTR 327

  Fly   351 NLF-QIERDTTQLLTGETFAGGEAGMAVPETVCT-PRAVGISVDVNVYEPHL-----LAGTMAHM 408
            .|. ::..|..||:.||:|.|...|||...::|: .|:.|::||      ||     :|.|:||.
Zfish   328 ELLPRLRHDNAQLIMGESFDGTTVGMASQSSMCSKDRSGGVNVD------HLVSVLGVASTVAHE 386

  Fly   409 IGHNIGMGHDDGREECFCRD---WHGCIMAQS---IVGQENVQPYKFSECSKKDYIDALRTGHGL 467
            :|||:||.||.....|.|::   ..||||..|   :.||      .||.||::|...:|..|.|:
Zfish   387 LGHNLGMSHDTADRRCHCQNEPRLGGCIMEPSTGFMPGQ------LFSSCSERDLSLSLLHGGGM 445

  Fly   468 CLLNKPNEIEL--RRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCAS-GACCDQC 529
            ||.|.|....|  ...|||..||:.||||||..:||. |.||:..||||...|||:| |.||:.|
Zfish   446 CLFNVPQPESLLGGPRCGNLYVEKGEECDCGLLDECN-DPCCNASTCKLVPGAQCSSDGICCENC 509

  Fly   530 RLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCE 594
            :||....:||:...||||||:|.|....||.:||.:||.||    .|.|.||:.|.|.:|..||:
Zfish   510 KLRVAGSVCREPLGECDLPEHCTGSSPYCPPNVFLQNGEPC----KGGSSYCYSGVCASLDDQCQ 570

  Fly   595 AIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQ 659
            .:||...:.|...|:...|.:|:..|:||:..|..||.|...:|.||.:||:.|..:|:.....:
Zfish   571 MLWGQNSTRAPPICFSSVNKQGNKYGNCGQMPNGSYIPCLKWDVHCGRIQCQGGGERPLLGSNAE 635

  Fly   660 LYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTC--VSLFPHVDQTKC 722
            :.:.|:| :...:|.|:.|...:| :...:..:|..||.||.|..|::|.|  ||:| .||:.:.
Zfish   636 ILTTTVI-LNQSDFTCRGTYFNLG-DDVSDPAMVLQGTACGPNKACVDQKCRDVSMF-GVDECRS 697

  Fly   723 PANSQGLECSEHGVCTNTNRCFCDMGWGGNDC------SSVVLLTTALPTEALPTPENTIKMEKK 781
                   :|..||||.:...|.||.||...||      .||         ::.|..|..
Zfish   698 -------KCHGHGVCNSNKNCHCDEGWAPPDCRYSGNGGSV---------DSGPAQEPR------ 740

  Fly   782 ETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLAVCYRRKTTTLKY--DPPYSK----KPIAK 840
                 .||..|::.|  ||.|.|:.    :|...:|:.:.|....|.|  ..|::|    :.|..
Zfish   741 -----DSDPARVALL--VIFLFVLP----VSLLFVALRFPRCRRGLVYLGHTPFNKTRQSRGITV 794

  Fly   841 SY 842
            ||
Zfish   795 SY 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	33/105 (31%)
		Reprolysin	270..473	CDD:279729	74/217 (34%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	73/215 (34%)
		Disintegrin	488..562	CDD:278623	38/74 (51%)
		ACR	566..713	CDD:214743	49/148 (33%)
adam15	XP_001335318.4	Pep_M12B_propep	83..>175	CDD:279848	30/85 (35%)
		Reprolysin	249..451	CDD:279729	74/217 (34%)
		ZnMc_adamalysin_II_like	249..449	CDD:239797	73/215 (34%)
		Disintegrin	468..542	CDD:278623	38/74 (51%)
		ACR	545..687	CDD:214743	48/147 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8112
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950