Protein Alignment mmd and adam23a

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: XP_001923262.2
• Gene: adam23a / 794175
• ZFINID: ZDB-GENE-070810-2
• Length: 785
• Species: Danio rerio
• Alignment Length: 845
• Identity: 251/845 - (29%)
• Similarity: 377/845 - (44%)
• Gaps: 136/845 - (16%)

  Fly     9 ILIIAQLCVFVTSAGEADYTLDDSFWNE---ESPVGEVERLLKEYRQNQELVRRIGGHYYQIIYP 70
            :.::|.:.:.|.|:.....|:..|..||   :..|.|..|  :....:.....:.|.|...|.||
Zfish     7 LCLLASIIISVPSSIATSSTVSSSVQNEALRDQHVSETPR--EATAPDDSTEGKTGEHPVTITYP 69

  Fly    71 VQLRH----------HEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHK 125
            .:|.:          |:   :.||..:....||               ..|..:.|..:.||...
Zfish    70 SRLIYYLNEESESTFHD---LDTRAKNQAGDGQ---------------DVHLAQASFQLDAFGTT 116

  Fly   126 FRLDLELNSQLLSPNIQQKHYH-------VGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCN 183
            |.|||.||:.|||.:..:.||.       .||          |||||||.|:....:.||..|||
Zfish   117 FTLDLTLNNDLLSSDYIEIHYENDKPVLSRGG----------EHCYYHGHVRGKEDSRAALSTCN 171

  Fly   184 GVSGVIHIGNETFVIHP---FYGGDLSKHPHVIFEARTKANKGCANSGNLDSWR----------- 234
            |:.|:...||..::|.|   .:..:....||.:   |..::.|..:..  |.|.
Zfish   172 GLHGMFDDGNFVYLIEPQKQTHTAETEARPHTL---RRTSSLGLTSIP--DDWTADDPDEEKRIF 231

  Fly   235 -----LSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEV 294
                 |.||.|...                  .|::.|..||:|..|:.|...|.|..  ::...
Zfish   232 ASMPWLKRRRKRAM------------------PRNIFEEMKYLEIMIVADHNTFKKHR--SKKHT 276

  Fly   295 IHDAIQVANIADLYFR-TLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERD 358
            .:.|..:.|:.|..|: .|||||.:|.:|.|.....:....|.: :.:.:|:.|..:|: .|..|
Zfish   277 RNTAKSLVNLVDAIFKEQLNTRVVLVAVEIWTDKDRIPLSVKPL-EMLKDFSKYRQQNI-NINAD 339

  Fly   359 TTQLLTGETFAGGEAGMAVPETVCT-PRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDG-- 420
            ...|.|..||..|.:.:.....||: .|.:|::...|.:   .:||..:..:..|:|:..|..
Zfish   340 AVHLFTNMTFHYGRSSVGYIGGVCSKARGIGVNEFGNTW---TMAGFFSQSLAQNLGIQWDPSLR 401

  Fly   421 REECFCRD-WHGCIMAQSIVGQENVQ-PYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCG 483
            |:||.|.| |.||||..:     .|| |.|||:||..||.:.|..|...||.||||::.....||
Zfish   402 RKECGCMDSWLGCIMEDT-----GVQHPRKFSKCSITDYRNFLLRGGASCLFNKPNKLFEATECG 461

  Fly   484 NKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCD-QCRLRPKDYICRDSNNECDL 547
            |..||..||||||...||..| ||.  .|.|.:.|.|:.|.||: .|...|:.|.||.:.|:||:
Zfish   462 NGYVEVGEECDCGARMECYKD-CCK--KCSLSNGAHCSDGPCCNGTCLFYPRGYSCRFAVNDCDI 523

  Fly   548 PEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQF 612
            .|.|.|:.||||.::.|::|..|.|::    |.|:.|.|.|...||:.|||.....:::.|||:.
Zfish   524 SETCSGDSGQCPPNLHKQDGYSCQLNQ----GRCYSGECKTRESQCKYIWGPKAGGSEKHCYEKL 584

  Fly   613 NSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKA 677
            |::|:..|:||||.:: ::.|...:|.||.|.|....|.|....:....:.|..:.:|:..:|
Zfish   585 NTEGTEKGNCGRDGDK-WVPCSKHDVFCGYLLCSSTGRIPRIGTLKGDVTPTTFNHQGRLVDC-- 646

  Fly   678 TSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNR 742
            :.|.|..:...:.|.|:||||||.:::||.:.|:.: ..::.|.||:...|..||.||||.|...
Zfish   647 SGGHVLLDDDTDLGYVEDGTPCGPSMMCLERKCLPI-SSLNLTACPSGPGGRVCSSHGVCNNEAT 710

  Fly   743 CFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNR-ISTLTMVIILTVIV 806
            |.||..|.|.|||             :..|.....:.:...|.|.|..|. |.::...|::..||
Zfish   711 CTCDATWAGTDCS-------------MHDPPKEPPVIEDPGPKGPSATNLIIGSIAGAILMAAIV 762

  Fly   807  806
            Zfish   763  762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	38/119 (32%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	64/206 (31%)
		Disintegrin	488..561	CDD:459709	34/73 (47%)
		ACR	566..713	CDD:214743	47/146 (32%)
adam23a	XP_001923262.2	Pep_M12B_propep	97..202	CDD:460254	38/129 (29%)
		Reprolysin	254..451	CDD:426256	65/208 (31%)
		Disintegrin	466..537	CDD:459709	34/73 (47%)
		ACR	541..682	CDD:214743	47/147 (32%)