DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and adam28

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001070186.1	Gene:	adam28 / 767749	ZFINID:	ZDB-GENE-060929-532	Length:	293	Species:	Danio rerio

Alignment Length:	367	Identity:	78/367 - (21%)
Similarity:	134/367 - (36%)	Gaps:	87/367 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NLILIIAQLCVFVTSAGEADYTLDDSFWNEESPVGEVERLLKEYRQNQELVRRIGGHYYQIIYPV 71
            :|:|.|..|||          :||.|       ||.:..|   :|:..|:||.||.|
Zfish     5 HLMLWIFTLCV----------SLDPS-------VGHIHEL---HRKVYEIVRPIGLH-------- 41

  Fly    72 QLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQL 136
                           .|.|...:.||               .|....:........:.|:.|:.:
Zfish    42 ---------------DLQKRDLQSRP---------------DRVKYAMTLGGRDIEMHLQKNTGM 76

  Fly   137 LSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPF 201
            |:.:..:.:|...|.||.....|::.|||||.:.:...:..:..||:|:.|......:..:|.|.
Zfish    77 LTKDYSETYYTEDGMLVTTTPADLDLCYYHGKILNDSASLVSMSTCDGLRGYFQTAEQRVLIEPL 141

  Fly   202 YGGDLSKHPHVIFEARTKANK---GCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKR 263
            .......|....:|...:|..   |..|:    :|..|.         .||...||:.....:..
Zfish   142 SEDSDGDHAAFKYEDVNEATPRVCGVTNT----TWDESG---------DGVPPRILKTRSRSSGP 193

  Fly   264 DVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAI-QVANIADLYFRTLNTRVSVVYIETWGKN 327
            .:.:..||.|..::.|...:.|.|..  .|.:...| ::.|..:..::.:||.|::...|.|..|
Zfish   194 TLFQRQKYNEFFLVADNREYKKLNSD--LEKLRKRIFEIINFINNVYKEINTFVALTGFEVWTDN 256

  Fly   328 QAVIDGSKDISKA----ISNFNDYTSRNLFQIER-DTTQLLT 364
            ..:     .:|.|    :.:|..:.:.:|.:.:| |...|||
Zfish   257 DKI-----TVSAASGATLDSFTKWRNSDLIKRQRHDNAHLLT 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	21/106 (20%)
		Reprolysin	270..473	CDD:279729	24/101 (24%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	24/101 (24%)
		Disintegrin	488..562	CDD:278623
		ACR	566..713	CDD:214743
adam28	NP_001070186.1	Pep_M12B_propep	44..149	CDD:279848	23/119 (19%)
adam28	NP_001070186.1	ZnMc_adamalysin_II_like	200..>293	CDD:239797	22/99 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010