Protein Alignment mmd and adam10

DIOPT Version :9

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_001037869.1
• Gene: adam10 / 733451
• XenbaseID: XB-GENE-945388
• Length: 749
• Species: Xenopus tropicalis
• Alignment Length: 759
• Identity: 169/759 - (22%)
• Similarity: 265/759 - (34%)
• Gaps: 258/759 - (33%)

  Fly    61 GGHYYQIIYPVQ--LRHHEKMGISTREVSLPKPGQRPR---PHDDSGFNRGRTKKHFHRTSLLIK 120
            ||||..   |:.  :||:|  |::....||.:..||.:   ..:|         :..|   |..:
 Frog    17 GGHYGN---PLNKYIRHYE--GLNYNMDSLHQKHQRAKRAVSQED---------QFVH---LDFQ 64

  Fly   121 AFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCY-----------YHGTVKDYPG 174
            |...:|.|.::.::.|.||:.:   ..|||..||   :|..|.|           .||:|.|
 Frog    65 AHGRQFNLRMKRDTSLFSPDFK---LEVGGETVD---YDTSHIYTGQLFGEQGTLSHGSVVD--- 120

  Fly   175 ASAAFHTCNGVSGVIHIGNETFVIHP---------------FYGGDLSKHPHVIFEARTKANKGC 224
                    ....|.|.....||.:.|               .|..|..|:||     :..:..||
 Frog   121 --------GRFEGFIKTHQGTFYLEPSERFFKNQAVPFHSVMYHEDDIKYPH-----KYGSEGGC 172

  Fly   225 ANSG---NLDSWRLS---------RRTKHLSAGVAGVVEEILQAGVGRNKRDVREATK-----YI 272
            |:|.   .:..:::|         .:..|..:|..     ||:      |:...:|.|     ||
 Frog   173 ADSSVFQRMKEYQMSAQEESEKHDHKEDHEGSGPL-----ILR------KKRAAQAEKNTCQLYI 226

  Fly   273 ETAIIVDKAMFDKRNGSTRAEV-------------IHDAIQVANIADLYFRTLNTRVSVVYIETW 324
            :|     ..:|.||.|.||..|             |:.:...:.|.::.|.....|::|...|
 Frog   227 QT-----DHLFYKRYGETREAVIAQISSHVKAIDTIYQSTDFSGIRNISFMVKRIRINVTSDE-- 284

  Fly   325 GKNQAVIDGSKD-----------ISKAI-----SNFNDYTSRNLFQIERDTTQLLTGETFAGGEA 373
                      ||           :.|.:     .|.:||....:| .:||....:.|..:.|..:
 Frog   285 ----------KDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVF-TDRDFDDGVLGLAWVGAPS 338

  Fly   374 GMAVPETVCTPRAV-----------GISVDVNVYEPHLLAG----TMAHMIGHNIGMGHDDGREE 423
            |.:  ..:|....:           || :.|..|..|:...    |.||.:|||.|..||.| .|
 Frog   339 GSS--GGICERNKLYSDGKKKSLNTGI-ITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSG-NE 399

  Fly   424 C---------FCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELR 479
            |         |..:.:..:.|::..| :.:...|||.||.::....|......|.:.....|
 Frog   400 CTPGESKNLGFKENGNFIMYARATSG-DKLNNNKFSICSVRNISQVLDKKRNSCFVESGQPI--- 460

  Fly   480 RNCGNKVVEEDEECDCGTFEECALDQCC------DGITCKLKSEAQC--ASGACCDQ-CRLRPKD 535
              |||.:||:.|:||||..::|. |.||      :.:.|.||...||  :.|.||:. |..:.:.
 Frog   461 --CGNGLVEQGEQCDCGYSDQCK-DDCCYDANQPENLKCTLKPGKQCSPSQGPCCNSGCTFKLRS 522

  Fly   536 YICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYG 600
            ..||: .::|.....|:|...|||....:.|.:.|..:    :..|.:|.|
 Frog   523 EKCRE-ESDCAKMGTCNGVSAQCPPSDPRDNLTECNRA----TQVCIKGQC-------------- 568

  Fly   601 GSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEP---ENVQCGTLQCKDGERQPVNDGIDQLYS 662
                          .|||              ||.   |...||:...||          |:...
 Frog   569 --------------SGSI--------------CEKYDLEECTCGSSDGKD----------DKELC 595

  Fly   663 RTIISIKGQEFECKATSGQVGSNSYPEHG-----LVKDGTPCGD 701
            ......|.:...|.:|    ||.::..|.     .::.|:||.:
 Frog   596 HVCCMEKMKPHTCAST----GSEAWRAHFKGKTITLQPGSPCNE 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	30/132 (23%)
		Reprolysin	270..473	CDD:279729	57/260 (22%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	57/258 (22%)
		Disintegrin	488..562	CDD:278623	27/82 (33%)
		ACR	566..713	CDD:214743	25/144 (17%)
adam10	NP_001037869.1	Pep_M12B_propep	42..141	CDD:366707	28/127 (22%)
		ZnMc_TACE_like	220..460	CDD:239798	56/262 (21%)
		DISIN	467..546	CDD:214490	26/80 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010