DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam30

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_081941.1	Gene:	Adam30 / 71078	MGIID:	1918328	Length:	732	Species:	Mus musculus

Alignment Length:	774	Identity:	218/774 - (28%)
Similarity:	328/774 - (42%)	Gaps:	149/774 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 GISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQK 144
            |..:.|:::||.         ..|.:|........:.||  ....|.|:......:||.|    :
Mouse    36 GFDSYEITIPKV---------ISFKKGAQGVDSSLSYLL--QIEGKARVVHLRPKKLLLP----R 85

  Fly   145 HYHV-----GGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTC-NGVSGVIHIGNETFVIHPFYG 203
            |..|     .|.|::...|..:.|.|.|:|:....:.:...|| .|:.||::|.:..:.|.|...
Mouse    86 HLPVFSFTQEGSLIEDYPHIPDQCNYVGSVEGSQESESTLSTCMGGLRGVLNIDSRYYQIEPLRA 150

  Fly   204 GDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREA 268
            .  |...||::.. |:.|                    .:....|||:|.........:...|.:
Mouse   151 S--SSFEHVVYLV-TEDN--------------------FNNETCGVVDEETGGQTAEEEEMARIS 192

  Fly   269 T--------KYIETAII--VDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIET 323
            :        :|:|..::  :|:.:|.:.|.|   .::.|||.:|:|||.||:.::.::.:..:|.
Mouse   193 SFHQSYKHQRYLELVMVFDLDRFVFARGNMS---RMVDDAILLASIADTYFQDVSLKIQLKALEV 254

  Fly   324 WGKNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDTTQLLTGETFAGGEA---GMAVPETVCTP 384
            |.....:......:|:.:..|..|...:: .::..|...|.....:....|   |.|     |..
Mouse   255 WTYYNRIRLYYPSLSEVLGQFVHYKRNSMHHRLPADWFHLYIARRYIDANAWSWGRA-----CEE 314

  Fly   385 RAVGIS---VDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQP 446
            ...|.:   ::||:..|   |...||.:||.:||.||:  |.|.||....|||.....|
Mouse   315 FHAGSASSFLNVNILGP---ATWTAHELGHCVGMIHDE--EFCQCRGRKSCIMGTGRTG------ 368

  Fly   447 YKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEECDCGTFEECALDQCCDGIT 511
              ||.||...|..........||.:.| ::.:...||||:||..||||||:.|:|..|.|| |..
Mouse   369 --FSNCSYHQYFLHASYKMSYCLSDFP-KLHIVERCGNKIVENKEECDCGSKEDCKKDLCC-GPD 429

  Fly   512 CKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTG 576
            ||.|....|:||.||.:|...|..|:||...|||||.|||||..|.||.|.:|::|:||   :.|
Mouse   430 CKWKEGVNCSSGLCCHKCNFLPSGYVCRKEVNECDLEEYCDGTSGVCPDDSYKQDGTPC---RNG 491

  Fly   577 ISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCG 641
              |:||:..|.:..|||::|:|.....|..||||..|..|..:|:||......|.:|...|..||
Mouse   492 --GFCFRKGCRSRYLQCQSIFGRKAKEAPHQCYEAVNMLGDQSGNCGIVNATRYTRCHRGNTICG 554

  Fly   642 TLQCKDGERQPVN-DGIDQLYSRTII---SIKGQEFECKATS--GQVGSNSYPEHGLVKDGTPCG 700
            .|||       :| ..:.:....|||   .::|....|..||  |.:..:..|:.|.:.|||.||
Mouse   555 RLQC-------INVKALSKFPDHTIILSTYLRGDNLICWGTSYHGTMIPHGVPDIGDISDGTSCG 612

  Fly   701 DNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALP 765
            .|.:|||:||      ||.|....:....:|:..|||.|...|.|..||....|
Mouse   613 RNRVCLNRTC------VDYTNLKFDCLPDKCNSRGVCNNRKNCHCSYGWEPPFC----------- 660

  Fly   766 TEALPTPENTIKMEKKETPYGTSDQN-----RISTL----------TMVIILTVIVKCV 809
                           .|..||.|..:     ||..|          |::.::::||.|:
Mouse   661 ---------------VEVGYGGSLDSGPPGPRIEVLSTTSALYMLRTILFLVSMIVVCL 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	27/112 (24%)
		Reprolysin	270..473	CDD:279729	54/211 (26%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	54/209 (26%)
		Disintegrin	488..562	CDD:278623	39/73 (53%)
		ACR	566..713	CDD:214743	53/152 (35%)
Adam30	NP_081941.1	Pep_M12B_propep	58..158	CDD:279848	26/107 (24%)
		Reprolysin	202..393	CDD:279729	54/211 (26%)
		ZnMc_adamalysin_II_like	202..391	CDD:239797	54/209 (26%)
		Disintegrin	407..479	CDD:278623	39/72 (54%)
		ACR	483..624	CDD:214743	53/158 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836146
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850