DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and Adam34

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001128562.1	Gene:	Adam34 / 685846	RGDID:	1589040	Length:	712	Species:	Rattus norvegicus

Alignment Length:	674	Identity:	190/674 - (28%)
Similarity:	303/674 - (44%)	Gaps:	86/674 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 NRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGT 168
            ||......:...:|.|:...|  .::::....|:|.|.....|...|.|::........|||.|.
  Rat    53 NRNNISPGWLSYNLNIEGQRH--IINMKPKKNLISRNFILFTYTQQGDLLEEQPFVQNDCYYLGY 115

  Fly   169 VKDYPGASAAFHTCNG-VSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDS 232
            |.:.|.:....:||.| :.|::.|...|:.|.|  ....|...|:.::..|..::.......|..
  Rat   116 VDEDPESLVIINTCFGSLQGILEINGTTYEIMP--KSSSSTFEHLAYKVDTDKSESFTMRCGLSE 178

  Fly   233 WRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKY---------IETAIIVDKAMFDKRNG 288
            ..::|:.|             ||    .|...:.....|         |:..:::|...:..||.
  Rat   179 KEIARQMK-------------LQ----ENNDSILLQNPYENWWTHHRFIDYFVVLDHNRYVHRNN 226

  Fly   289 STRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNL- 352
            :| ...|.|.:|:.|..:.|:..::|.|.:..::.|.:.. :::..:||...::.|..:....:
  Rat   227 NT-TTCIQDMLQIVNGINGYYLQIDTDVVLTTLQVWSERN-LVNVEQDIQMVLTAFCTWKINTIG 289

  Fly   353 FQIERDTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVYEPHLL---AGTMAHMIGHNIG 414
            .:|..|...|.....: |...|:|...|||    :.::..||.:....|   |..:||.:|||:|
  Rat   290 NRIRHDIIHLYVKRGY-GIYLGLANVGTVC----ITLNCAVNSFISDSLSDMAFIIAHEMGHNLG 349

  Fly   415 MGHD-DGREECFCRDWHGCIMAQSIVGQENVQPY-----KFSECSKKDYIDALRTGHGLCLLNKP 473
            |.|| .|   |.| ....||||          ||     |||.||.::....:....  ||.:.|
  Rat   350 MMHDVSG---CTC-GRQSCIMA----------PYKSNSPKFSNCSYEEMYSVVNKRS--CLYDIP 398

  Fly   474 NEIELRRN---CGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKD 535
            :.::....   ||||:|||:|:||||..|.|..|.||.. .|.||..||||.|.||..|:..|..
  Rat   399 DALKTNLTLTVCGNKMVEEEEQCDCGNLESCLKDPCCSE-DCVLKPGAQCAFGLCCKDCQFLPTG 462

  Fly   536 YICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYG 600
            .:||...|||||||:|:|...:||.||:|::|:||    :| .|||::..|.....||..|:|.|
  Rat   463 TVCRKEKNECDLPEWCNGSSHECPGDVYKEDGNPC----SG-DGYCYKMACHQHDEQCRNIFGNG 522

  Fly   601 GSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTI 665
            ..:|...||.:.|.:|...|:||.|::: |.:|:|.:|.||.:||::....|.....:.::....
  Rat   523 SRSAGEICYTEMNKRGDRFGNCGNDSSK-YRRCQPADVFCGRIQCENVTELPQRKNHETVHYTHF 586

  Fly   666 ISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLE 730
            .::     .|.......|. ...:.|.|.|||.|..:.:|:::.|||      ::...:|.....
  Rat   587 NNV-----TCWTMDYHFGI-PIDDFGAVSDGTVCAPDYLCVDRKCVS------KSVLISNCSPQL 639

  Fly   731 CSEHGVCTNTNRCFCDMGWGGNDC 754
            |:..|||.|.:.|.||:.|...||
  Rat   640 CNMQGVCNNKHHCHCDITWEPPDC 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	25/107 (23%)
		Reprolysin	270..473	CDD:279729	55/221 (25%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	55/219 (25%)
		Disintegrin	488..562	CDD:278623	37/73 (51%)
		ACR	566..713	CDD:214743	42/146 (29%)
Adam34	NP_001128562.1	Pep_M12B_propep	44..160	CDD:396235	27/110 (25%)
		ZnMc_adamalysin_II_like	208..396	CDD:239797	54/210 (26%)
		Disintegrin	416..488	CDD:395147	37/72 (51%)
		ACR	493..628	CDD:214743	43/152 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2908
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.070