DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam12

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_017445729.1	Gene:	Adam12 / 679837	RGDID:	1583652	Length:	903	Species:	Rattus norvegicus

Alignment Length:	741	Identity:	242/741 - (32%)
Similarity:	350/741 - (47%)	Gaps:	97/741 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 KKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYP 173
            |.|....::.::..:.:..|.||.|..|::....:.||...|..|...|:..:||||||.|:...
  Rat    63 KDHPDVLTVQLQLESRELILSLERNEGLIANGFTETHYLQDGSDVSFTRNYTDHCYYHGHVQGDA 127

  Fly   174 GASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRR 238
            .:..:..||:|:.|:|...|:|:::.|. .....::..|..|........|.:..|..|..:.
  Rat   128 ASVVSLSTCSGLRGLIVFENKTYILEPM-KNTTDRYKLVPAENMKNIQGLCGSHHNKSSLTME-- 189

  Fly   239 TKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVAN 303
                     .|..|..|....|:||:..:.|||:|..|:.|...| :|.|....:|....|::||
  Rat   190 ---------DVFPEPSQMWGRRHKRETLKMTKYVELVIVADNREF-QRQGKDLEKVKQRLIEIAN 244

  Fly   304 IADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTS-------RNLFQIER---D 358
            ..|.::|.||.|:.:|.:|.|          .||.|...:.:.:||       |.|..:.|   |
  Rat   245 HVDKFYRPLNIRIVLVGVEVW----------NDIDKCSISQDPFTSLHEFLDWRKLKLLPRKSHD 299

  Fly   359 TTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREE 423
            ..||::|..|.|...|||...::||....|..|..:...|...|.|:||.:|||.||.||.....
  Rat   300 NAQLISGVYFQGTTIGMAPIMSMCTAEQSGGVVMDHSDSPLGAAVTLAHELGHNFGMNHDTLERG 364

  Fly   424 CFCR---DWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELR---RNC 482
            |.||   :..||||..| .|..  .|..||.||:||...:|..|.|:||.|.| |::..   |.|
  Rat   365 CSCRMAAEKGGCIMNPS-TGFP--FPMVFSSCSRKDLEASLEKGMGMCLFNLP-EVKQAFGGRKC 425

  Fly   483 GNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDL 547
            ||..||:.||||||..|||. ::||:..||.||.:|.||.|.||:.|:|:|....||.|:|.|||
  Rat   426 GNGYVEDGEECDCGEPEECT-NRCCNATTCTLKPDAVCAHGQCCEDCQLKPPGTACRGSSNSCDL 489

  Fly   548 PEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQF 612
            ||:|.|....||::|:..:|.||    .|:.|||:.|.|.|...||..:||.|...|...|:|:.
  Rat   490 PEFCTGTAPHCPANVYLHDGHPC----QGVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERV 550

  Fly   613 NSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRT-IISIKGQEFECK 676
            ||.|...|:||:|:...::|||..:.:||.:||:.|..:|| .|.:.:...| |...:|....|:
  Rat   551 NSAGDPYGNCGKDSKSSFVKCELRDAKCGKIQCQGGASRPV-IGTNAVSIETNIPQQEGGRILCR 614

  Fly   677 ATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTC--VSLF-PHVDQTKCPANSQGLECSEHGVCT 738
            .|...:| :..|:.|||..||.|.:..||||:.|  :|:| .|    ||     .::|...|||.
  Rat   615 GTHVYLG-DDMPDPGLVLAGTKCAEGKICLNRQCQNISVFGVH----KC-----AMQCHGRGVCN 669

  Fly   739 NTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRI-----STLTM 798
            |...|.|:..|....|.                         |....|::|...|     ..||:
  Rat   670 NRKNCHCEAHWAPPFCD-------------------------KFGFGGSTDSGPIRQADNQGLTV 709

  Fly   799 VIILTVIVKCVFISFATLAVCYRRKT 824
            .|:::|:  |:..  |...|..:|||
  Rat   710 GILVSVL--CLLA--AGFVVYLKRKT 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	27/103 (26%)
		Reprolysin	270..473	CDD:279729	75/215 (35%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	74/213 (35%)
		Disintegrin	488..562	CDD:278623	38/73 (52%)
		ACR	566..713	CDD:214743	54/149 (36%)
Adam12	XP_017445729.1	Pep_M12B_propep	64..160	CDD:279848	26/96 (27%)
		Reprolysin	212..414	CDD:279729	75/215 (35%)
		ZnMc_adamalysin_II_like	212..412	CDD:239797	74/213 (35%)
		DISIN	431..505	CDD:214490	38/74 (51%)
		ACR	508..650	CDD:214743	54/147 (37%)
		CAC1F_C	<751..>895	CDD:293490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7582
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020