DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and adam19

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001035105.1	Gene:	adam19 / 677730	XenbaseID:	XB-GENE-993485	Length:	911	Species:	Xenopus tropicalis

Alignment Length:	872	Identity:	249/872 - (28%)
Similarity:	389/872 - (44%)	Gaps:	169/872 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 KHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPG 174
            |:.....||:||......|.|..|.|.:.||.::.||.:....|....:..|||||||.|::...
Frog    62 KYPEHAELLVKAEGQDLILSLHRNEQFIHPNYRETHYSLNYTRVVRTPNMTEHCYYHGIVQEQDN 126

  Fly   175 ASAAFHTCNGVSGVIHIGNE-TFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRR 238
            :|.....|:|:.|:|.:.|. ::::.|..|.|   ..|||::|.   :.|.:...:..|.....:
Frog   127 SSVVISICSGIRGMITLSNNLSYIVEPLPGED---GRHVIYKAE---HLGLSRICHGHSIHFEEK 185

  Fly   239 TKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVAN 303
            ...|::.::|        ...|.:|:..|..:.:|..::.|.|.|.|.: |...|.....::|.|
Frog   186 LPTLTSNLSG--------HHSRVRRENVEGERCVELYLVADYAEFQKHD-SDLEETQRKMLEVMN 241

  Fly   304 IADLYFRTLNTRVSVVYIETWGKNQAVIDGSK-DISKAISNFNDYTS--------RNLFQ-IERD 358
            ..|.::|.||.|:::|.:|.|      ..|.| ::|:     |.|::        |.|.| ...|
Frog   242 YIDKFYRALNIRIALVGLEVW------TAGDKCNVSE-----NPYSTLRAFLSWRRKLLQHTPHD 295

  Fly   359 TTQLLTGETFAGGEAGMAVPETVCTP-RAVGISVDVNVYEPHL-----LAGTMAHMIGHNIGMGH 417
            ..||:||.:|.|...|:|..:.:|:. ::.|:::|      |.     :|.||||.:|||.||.|
Frog   296 NAQLITGRSFYGTTIGLAPLQAMCSVYQSGGVNMD------HSDNAIGVAATMAHELGHNFGMSH 354

  Fly   418 DDGREECFCR-DWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIEL--R 479
             |....|..: :..|||||.|   ..:..|..|:.|:|::.....|:|.|:||.|.|:...|  .
Frog   355 -DAAGCCTAKPEEGGCIMAAS---TGHPFPKVFNACNKQELDRFFRSGGGMCLSNLPDTKTLFGG 415

  Fly   480 RNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNE 544
            ..|||..:||.|:||||..|:|. :.||:..||.|.:.|.||.||||.:|:|||..:.||..:..
Frog   416 PRCGNGFLEEGEQCDCGDPEQCN-NPCCNATTCTLMAGADCAHGACCLRCKLRPPGFPCRKPSRP 479

  Fly   545 CDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCY 609
            |||||:|.|:...||.:.|:.:|:.|    .|...:|:.|.|.|...||:.:||.....|...|:
Frog   480 CDLPEFCTGQSAVCPPNSFQLDGTLC----QGEQAFCYNGRCLTHQQQCQQLWGARSRVAPDLCF 540

  Fly   610 EQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVND---GIDQLYSRTIISIKGQ 671
            |..|..|...|:||||.:..|..||..:|.||.:||.....:|:..   .||     |.|:|:|:
Frog   541 ELINVAGDQYGNCGRDMSGTYRSCEGRDVMCGKIQCLSQASKPMESNAVAID-----TTITIEGK 600

  Fly   672 EFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSL-FPHVDQTKCPANSQGLECSEHG 735
            ..:|:.|......:...:.|||..||.||.|.||.:..|.:. |..||:  |     ..:|..:|
Frog   601 RVQCRGTHIYKEEDDLMDPGLVLTGTKCGLNQICFDGQCRNTSFLQVDE--C-----AKKCHGNG 658

  Fly   736 VCTNTNRCFCDMGW----------GGN--------DCSSVVLLTTALP----------------- 765
            :|.|...|.|..||          ||:        |.|..::|...:|
Frog   659 MCNNNRNCHCFAGWRPPFCNQTGNGGSIDSGPVPEDGSLALVLWICIPLALLAGMALSLAMFFYV 723

  Fly   766 ---------TEALPTPENTIKMEKKETP----YGTSDQNRISTLTMVIILTVIVKCVFISFATLA 817
                     ||:.|.   |..:.|.::|    .|::.:.|..       :.:..|...:.:.||.
Frog   724 FRIRGRQAKTESCPA---TCPLHKSDSPTKHGVGSTSKQRPQ-------VPMQPKSPPVLYPTLR 778

  Fly   818 VCYRRKTTTLKYDPPYSKKPIAKSYGGAA---TAPNHHSVEEVSLDGSSKLVYANQTGFRDKGIH 879
            |        .|.....|:....:..||||   :|.:|||.:::. .|:.|:            :|
Frog   779 V--------EKSQSAASQHHQEQPEGGAAKYSSAISHHSNQDLK-GGAGKI------------LH 822

  Fly   880 GRRYTTCGEDDQSHAEKGILKKHGYGL 906
            |          .|:.::|...|.||.:
Frog   823 G----------VSYLQQGGAIKTGYAM 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	32/103 (31%)
		Reprolysin	270..473	CDD:279729	67/219 (31%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	66/217 (30%)
		Disintegrin	488..562	CDD:278623	36/73 (49%)
		ACR	566..713	CDD:214743	49/149 (33%)
adam19	NP_001035105.1	Pep_M12B_propep	63..163	CDD:279848	31/102 (30%)
		Reprolysin	211..407	CDD:279729	67/217 (31%)
		ZnMc_adamalysin_II_like	211..405	CDD:239797	66/215 (31%)
		DISIN	424..498	CDD:214490	36/74 (49%)
		ACR	500..642	CDD:214743	49/150 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8218
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48880
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010