Protein Alignment mmd and adam12

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_001035103.1
• Gene: adam12 / 677729
• XenbaseID: XB-GENE-982139
• Length: 925
• Species: Xenopus tropicalis
• Alignment Length: 885
• Identity: 284/885 - (32%)
• Similarity: 398/885 - (44%)
• Gaps: 164/885 - (18%)

  Fly     8 LILIIAQLCV---FVTSAGEADYTLDDSFWNEESPVGEVERLLKEYRQNQELVRRIGGHYYQIIY 69
            |.|:|..||:   .:.|..:.:               .||..|:..||..|..:.   .:|:||.
 Frog    15 LHLLILLLCLSWGVIPSQAQGE---------------NVEGKLESSRQQTEKEKH---EHYEIIV 61

  Fly    70 PVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNS 134
            |..||..|...|.:  ||                    ||.|.....:|:||.:.:..:.||.|.
 Frog    62 PYLLRGEEWEAIGS--VS--------------------TKSHPPAMKVLLKAKDIRLLISLERNK 104

  Fly   135 QLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIH 199
            .|.:.|....||...|..|....:..:||||||.|:.|..:|.:..:|:|:.|:|.:.|..:|:.
 Frog   105 GLFAGNFSTTHYTEDGVFVSTALNYTDHCYYHGKVEGYSESSVSVSSCSGLRGLITLENRAYVLE 169

  Fly   200 PFYGGDLSKHPHVIFEA-RTKANKG-CANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNK 262
            |......|   |:.::| ..|...| |:...||....||...:|            .|....|:|
 Frog   170 PQANSTTS---HLFYQAEHLKLISGSCSQHFNLSGVSLSDNFQH------------SQDTFKRHK 219

  Fly   263 RDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKN 327
            ||..:.|||:|..|:.|...: :|.|....:|.|..|.:||..|.:||.||.||::|.:|.|.
 Frog   220 RDTVKTTKYVELVIVADNREY-QRQGKDVDKVKHRLIGMANYVDKFFRPLNIRVALVGVEIWS-- 281

  Fly   328 QAVIDGSK-----DISKAISNFNDYTSRNLF-QIERDTTQLLTGETFAGGEAGMAVPETVCT-PR 385
                |..|     |....:..|.|:....|. |...|..||::|..|.|...|||...::|| .:
 Frog   282 ----DSDKCSITQDPFTTLQEFLDWRKLKLLPQKPHDNAQLVSGVYFQGTTIGMAPIMSMCTADK 342

  Fly   386 AVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCR---DWHGCIMAQSIVGQENVQPY 447
            :.||.:| :...|...|.|:||.:|||.||.||.....|.||   |..||||..|     ...|:
 Frog   343 SGGIVMD-HSGNPLGAAVTLAHELGHNFGMNHDTLERGCNCRGSADNGGCIMTPS-----TAYPF 401

  Fly   448 K--FSECSKKDYIDALRTGHGLCLLNKPNEIEL--RRNCGNKVVEEDEECDCGTFEECALDQCCD 508
            .  ||.|.|||...:|..|.|:||.|.|...|.  .:.|||..|||.|:||||..:||. :.||:
 Frog   402 PTVFSSCGKKDLDSSLEKGVGMCLYNMPEVTESFGEQKCGNGYVEEGEQCDCGEPDECT-NPCCN 465

  Fly   509 GITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLS 573
            ...|.||..|.||.|.||:.|:|:|....|||:||.|||||:|.|....||::|:..:|.||
 Frog   466 ASLCMLKPGAVCAHGLCCEDCKLKPAGTPCRDANNFCDLPEFCSGTSAHCPANVYLHDGHPC--- 527

  Fly   574 KTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENV 638
             ..|.|||:.|.|.|...||..:||.|...|...|:|:.||.|...|:||:|:...:.|||..:.
 Frog   528 -FKIEGYCYNGVCQTHEQQCITLWGQGAKPAPGICFERVNSAGDPYGNCGKDSTGSFTKCENRDA 591

  Fly   639 QCGTLQCKDGERQPVNDGIDQLYSRTIISI-KGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDN 702
            :||.:||:.|..:|| .|.:.:...|.|.: :|:...|:.|...:| :..|:.|||..||.|.:.
 Frog   592 KCGKIQCQGGANRPV-IGTNAVSIETNIPLQEGRRILCRGTHVYLG-DDLPDPGLVLAGTKCEEG 654

  Fly   703 LICLNQTC--VSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGW----------GGNDCS 755
            .||||:.|  :|:|...|   |     .|:|..||||.|...|.|:..|          ||:..|
 Frog   655 KICLNRKCQNISIFGVHD---C-----ALKCHGHGVCNNKKNCHCEAEWAPPFCDKHGFGGSVDS 711

  Fly   756 SVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLAVCY 820
            ..|.|                            ..|| |.:|.:|   |.:.|:|:  |...|..
 Frog   712 GPVRL----------------------------HDNR-SLITGMI---VTIGCIFL--AAFIVYL 742

  Fly   821 RRKT----------TTLKYDPPYSKKPIAKSYGGAATAPN 850
            :|||          ||::     ..:.:..|.||.:..||
 Frog   743 KRKTLFQWLFSNKKTTIE-----KLRSVRPSRGGCSNEPN 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	33/109 (30%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	76/212 (36%)
		Disintegrin	488..561	CDD:459709	37/72 (51%)
		ACR	566..713	CDD:214743	54/149 (36%)
adam12	NP_001035103.1	Pep_M12B_propep	58..181	CDD:460254	42/147 (29%)
		Reprolysin	227..429	CDD:426256	77/214 (36%)
		DISIN	446..520	CDD:214490	37/74 (50%)
		ACR	523..665	CDD:214743	54/147 (37%)
		PHA03247	<781..924	CDD:223021