Protein Alignment mmd and adam33

DIOPT Version :9

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: XP_012819411.2
• Gene: adam33 / 677728
• XenbaseID: XB-GENE-988107
• Length: 913
• Species: Xenopus tropicalis
• Alignment Length: 797
• Identity: 244/797 - (30%)
• Similarity: 382/797 - (47%)
• Gaps: 116/797 - (14%)

  Fly   114 RTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAA 178
            |..:|:.:...:..|.:|.|.:|.:|...:.|| ..|.:|..:.:..|||||||.|:.|..:|.|
 Frog    62 RGEILVTSEGRRLILKVERNHRLFAPGYTETHY-TDGQMVTLSPNHTEHCYYHGQVQGYDDSSVA 125

  Fly   179 FHTCNGVSGVIHI-GNETFVIHPFYGGDLS-KHPHVIFEARTKANKG--CANSGNLDSWRLSRRT 239
            ..||:|:||:|.: .|:::.:.|.   ::| |..|.:........||  |.:.|
 Frog   126 LTTCSGISGLIVLRTNDSYYLSPL---EVSGKETHSLVRTEHLPIKGGSCGHEG----------- 176

  Fly   240 KHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRN---GSTRAEVIHDAIQV 301
             |..:..:...|.....|..|.:|:|..:.||:|..|:.|.:||.|:|   |||:..|    :::
 Frog   177 -HSGSTTSYFKEFTAPPGHHRVRRNVWRSQKYMELFIVADYSMFMKQNRNLGSTKQRV----LEI 236

  Fly   302 ANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGE 366
            ||..|.::.::|.:|:::.:|.|.:... .|.:.|.:.::.:|..:..:...:.:.|..||:||.
 Frog   237 ANYVDKFYMSMNIKVALIGLEVWTERDQ-CDVNDDANDSLRSFLQWKQKLRSRKKHDNAQLITGV 300

  Fly   367 TFAGGEAGMAVPETVCT-PRAVGISVDVNVYEPHLL--AGTMAHMIGHNIGMGHD-DGREECFCR 427
            ||.|...|||..|.:|| ..:.|:|:|   :..:.:  |.||||.||||.||.|| ||   |...
 Frog   301 TFKGTTIGMAPLEGMCTAENSGGVSMD---HSENAIGAAATMAHEIGHNFGMSHDNDG---CCVE 359

  Fly   428 ---DWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKP--NEIELRRNCGNKVV 487
               :..|||||.|   ..:..|.|||.||::..:...|.|.|:||.|.|  |::.:.:.|||..:
 Frog   360 ATPEQGGCIMAAS---TGHPFPRKFSRCSQQQLMSYFRKGGGMCLFNMPNTNDLVMGKKCGNGFL 421

  Fly   488 EEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCD 552
            ||.|:||||..|||. :.||:...|.||:.|:||.|.||..|||:.....||:....|||||:|.
 Frog   422 EEGEQCDCGEPEECT-NPCCNANNCTLKAGAKCAHGECCQDCRLKSAGTQCREMAGSCDLPEFCT 485

  Fly   553 GEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGS 617
            |:...|||:|:..:||.|...:    .||:.|.|.|...||..:||.|...|...|::..|..|.
 Frog   486 GDAPFCPSNVYMLDGSSCAFGE----AYCYNGMCLTHQQQCIHLWGSGAVVAPDFCFQDVNKAGD 546

  Fly   618 INGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQV 682
            ..|:||::....::||...:.:||.:||:....:|.:..:.:: ..||| |.|.:.:|:......
 Frog   547 QYGNCGKNGRGQFVKCTSRDAKCGKIQCQTSSEKPRDPSMVKV-DNTII-INGYKMKCQGVHAYS 609

  Fly   683 GSNSYPEHGLVKDGTPCGDNLICLNQTCVSL-FPHVDQTKCPANSQGLECSEHGVCTNTNRCFCD 746
            ......:.|||..||.|||.::|.::.|.:. |..:||  |.:     :|:.||||.:...|.|.
 Frog   610 MQEEEGDPGLVMTGTKCGDGMVCKDRRCQNASFFELDQ--CVS-----KCNGHGVCNSNRNCHCH 667

  Fly   747 MGW----------GGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVII 801
            .||          ||:..|.             |.|        .:.|.|.       |:.:||:
 Frog   668 SGWAPPYCDKPGPGGSQDSG-------------PAP--------NDIPVGV-------TIFLVIL 704

  Fly   802 LTVIVKCVFISFATLAVCYRRKTTTLKYDPPYSKKPIAKSYGGAATAPNHH--------SVEEVS 858
            ..|::    :..|...|.:.||..:|.  ..:.||..||.....||.|..:        ::.::|
 Frog   705 FLVLL----LGLAIAMVYWYRKPGSLL--NKWLKKSKAKCSLCKATQPKANRAYSSKIFTMRDIS 763

  Fly   859 LDGSSKLVYANQTGFRD 875
            ....|.   :.||..||
 Frog   764 YPVKSD---SKQTHSRD 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	33/100 (33%)
		Reprolysin	270..473	CDD:279729	74/212 (35%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	73/210 (35%)
		Disintegrin	488..562	CDD:278623	36/73 (49%)
		ACR	566..713	CDD:214743	43/146 (29%)
adam33	XP_012819411.2	Pep_M12B_propep	36..158	CDD:396235	32/99 (32%)
		Reprolysin	206..405	CDD:396140	74/212 (35%)
		DISIN	422..496	CDD:214490	36/74 (49%)
		ACR	498..639	CDD:214743	43/146 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8218
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48880
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010