Protein Alignment mmd and adam19b

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: XP_699915.6
• Gene: adam19b / 571252
• ZFINID: ZDB-GENE-070705-541
• Length: 923
• Species: Danio rerio
• Alignment Length: 881
• Identity: 251/881 - (28%)
• Similarity: 366/881 - (41%)
• Gaps: 199/881 - (22%)

  Fly    92 GQRPRPHDDS--------GFNRGRTK------KHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQ 142
            |.....||||        ..:..|.|      ||.....:.|........|.|:.|.:|.|...|
Zfish    50 GDSSHIHDDSEHYITFPQWISPARHKRSEMVVKHPSEAEVKITVGGEDLILQLQRNEELFSSEYQ 114

  Fly   143 QKHYHVGGYLVDGNRHDI-----EHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNE-TFVIHPF 201
            :..|.     .:|||...     :||||||:||:..|:|....||.|:.|:|.:.|. :::|.|.
Zfish   115 EIWYD-----TNGNRQFSRPSIRDHCYYHGSVKEAEGSSVVISTCAGLRGLITVNNSVSYMIQPL 174

  Fly   202 YGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAG----------VVEEILQA 256
             ........|.:|.                    |||.| |.||..|          .::|::..
Zfish   175 -ANQTHSQGHAVFN--------------------SRRLK-LPAGTCGHHHGDGHHTESLQELIDV 217

  Fly   257 -----GVGRNKRDVREATKYIETAIIVDKAMFDKRN---GSTRAEVIHDAIQVANIADLYFRTLN 313
                 ...|.:|||..:.||:|..::.|.|.|...|   ..|:|::    ::.||..|.|:::|.
Zfish   218 MAKPQRTNRERRDVSSSMKYVELMVVADHAEFVNHNRDLEKTKAKL----LEAANFVDKYYKSLK 278

  Fly   314 TRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVP 378
            .||:::.:|.| .:|..|:.:.:....:..|..:..:.|.|:..|..||:||.:|.|...|:|..
Zfish   279 IRVALIRLEIW-NDQDKINVTDNPYSTLGAFLSWRRKQLPQLPNDNAQLVTGVSFHGTIIGLAPL 342

  Fly   379 ETVCTP-RAVGISVDVNVYEPHL-----LAGTMAHMIGHNIGMGHDDGREECFCR---DWHGCIM 434
            :.:|:. ::.|::.|      |.     :|.||||.:|||.||.||.  ..| ||   :..||||
Zfish   343 KAMCSEYQSGGVNSD------HSNSAVGIAATMAHELGHNFGMSHDS--PGC-CRAQAEDGGCIM 398

  Fly   435 AQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIEL--RRNCGNKVVEEDEECDCGT 497
            |.:....   .|..|:.|::.:....|.:|.|.||.|.||...:  .:.|||..:||.||||||.
Zfish   399 AAATGAP---FPRVFNSCNQNELKRYLSSGGGKCLFNPPNTRVMYGGQRCGNGYLEEGEECDCGE 460

  Fly   498 FEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDV 562
            .|||: ..||:...|.|||.|:||.|.||.:|:|:....:||..:..|||||||||:...||::.
Zfish   461 VEECS-SPCCNAHNCTLKSGAECAHGVCCHECKLKSPGVMCRPPSGSCDLPEYCDGKSESCPANF 524

  Fly   563 FKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDAN 627
            |..:||.|...    |.||:.|.|.||..||.::||.....|...|:...|..|...|:||:|..
Zfish   525 FLMDGSSCASG----SAYCYTGMCLTLEQQCLSLWGKDARPAPDLCFTDVNKAGDAFGNCGQDLM 585

  Fly   628 EHYIKCEPENVQCGTLQCKDGERQPVND---GIDQLYSRTIISIKGQEFECKAT------SGQVG 683
            ..|.||...|.:||.:||:....:|:..   .||     |.|....|:..|:.|      ..:..
Zfish   586 GTYRKCTERNAKCGKIQCQSSASKPLESNAVAID-----TTIRSGQQKILCRGTHVWPHGHAKEN 645

  Fly   684 SNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMG 748
            .|...:.|||..||.||||.||....|      .|.:...|:....:|..||:|.|.:.|.|..|
Zfish   646 QNDTLDPGLVLTGTKCGDNAICFEGEC------RDASFLQADECSTKCQGHGLCNNNHNCHCHSG 704

  Fly   749 WGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNR-ISTLTMVIILTVIVKCVFIS 812
            |....|.:                         ..|.|:.|... ||..:..::|.::.....::
Zfish   705 WAPPFCGT-------------------------SGPGGSLDSGPVISQSSFYLVLVLLSLSFLLA 744

  Fly   813 FATLAVCYRR--------------KT----------------------------------TTLKY 829
            .|.|.||:.|              ||                                  .||:.
Zfish   745 LAVLGVCWCRCKQRFLSTKSPALPKTQTCINVPDTPEPKSHTTGHANPVFQPKKAPADEQATLRA 809

  Fly   830 D---PPYSK----KPIAKSYGGAATAPNHHSVEEVS 858
            .   ||.|:    :|..|.....|.||:.|.:.|.|
Zfish   810 SPTGPPRSRHSIIRPTVKPPPIPAYAPHKHLISEPS 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	34/121 (28%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	64/212 (30%)
		Disintegrin	488..561	CDD:459709	38/72 (53%)
		ACR	566..713	CDD:214743	51/155 (33%)
adam19b	XP_699915.6	Pep_M12B_propep	63..186	CDD:460254	34/128 (27%)
		Reprolysin	236..434	CDD:426256	65/214 (30%)
		DISIN	461..525	CDD:214490	30/64 (47%)
		ACR	527..674	CDD:214743	51/161 (32%)
		Atrophin-1	756..>907	CDD:460830	15/90 (17%)