DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and zgc:174164

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001107911.1	Gene:	zgc:174164 / 570656	ZFINID:	ZDB-GENE-030131-4971	Length:	801	Species:	Danio rerio

Alignment Length:	728	Identity:	223/728 - (30%)
Similarity:	337/728 - (46%)	Gaps:	100/728 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 CYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANK----G 223
            |||.|.|:.|..:..|..||.|:.|||.|||:::.:.|......::  |::|......::    |
Zfish   110 CYYQGHVEGYEDSLVALSTCEGIRGVIIIGNKSYGLEPVLHSKANE--HLLFLLEDSHSEPFVCG 172

  Fly   224 CANSGNL--DSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKR 286
            ..|..:|  |..|.:..:..|                 |.||.:.: |||:|.|::||:..|..:
Zfish   173 LENETSLSEDHSRYADMSMFL-----------------RKKRTLPQ-TKYVELALVVDQKRFIIK 219

  Fly   287 NGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGK-NQAVIDGSKDISKAISNFNDYTSR 350
            |.|..| |..:.:|:||:.|.||:.||.|::::.::.:.. |...:||  :....:..|.|:...
Zfish   220 NRSVNA-VRDEMVQLANLLDTYFKQLNIRIALIGLKIFDTGNPFSVDG--NAGDVLGRFVDWRKT 281

  Fly   351 NLF-QIERDTTQLLTGE-TFAGGEAGMAVPETVC---TPRAVGISVDVNVYEPHLLAGTMAHMIG 410
            .|. ||..|..||:.|: .:.||..|||...:||   |..|:.:..|.|:.....:|   ||.:|
Zfish   282 TLSPQIRNDAAQLVVGQGAYPGGVLGMAFVGSVCSASTSGAISVFSDNNLQYYSTVA---AHELG 343

  Fly   411 HNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNE 475
            ||:||.||.  ..|.|:    ||||.|..|..     |||:||...:...::.|.|.||.|.|.:
Zfish   344 HNLGMSHDS--NGCSCQ----CIMAPSASGST-----KFSDCSDNAFERLIQGGGGACLRNIPAQ 397

  Fly   476 ---IELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYI 537
               |.:.| |||.::|..|||||||.:||. ..||:..||.....:.||:|:||.:|::......
Zfish   398 DSIISVPR-CGNGILESGEECDCGTPQECN-TTCCNAATCTFTKGSTCAAGSCCQKCQIIVAGTP 460

  Fly   538 CRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGS 602
            ||.|.|.|||||||.||...||||.:..:|.||..:    :.|||:|.|.|...||:.|:|.|.:
Zfish   461 CRPSINPCDLPEYCGGESPYCPSDFYMMDGLPCNNN----AAYCFEGRCQTFDYQCKQIFGSGAT 521

  Fly   603 AADRQCYEQFNSKGSINGHCGRDANEHYIK-CEPENVQCGTLQCK-DGERQPVNDGIDQLYSRTI 665
            .||.:|:...|:.|:..|:||....  :.| |..:|..||.|||. :....|:...:      ::
Zfish   522 KADDKCFTNVNTYGNAFGNCGYSGT--FPKPCSVQNAMCGKLQCLFNSNNPPLGATV------SV 578

  Fly   666 ISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLE 730
            ..|:|....|......:|.: .|:...||..:.|....:|.|.||.:........||.|..   :
Zfish   579 QKIEGGTITCMNADFNMGPD-VPDPAYVKTASVCAPGKLCANFTCFNSSVMDQSRKCDAQR---D 639

  Fly   731 CSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRIST 795
            ||.:|||.:...|.|:.|||..:|:.             .....:|.....|..|...:...|..
Zfish   640 CSSNGVCNDRYHCHCNNGWGPPNCNK-------------GGRGGSIDSGPAEIDYSLRNGLLIFF 691

  Fly   796 LTMVIILTVIVKCVFISFATLAVCYRRKTTT--LKYDPPYSKKPIAKSYGGAATAPNHHSVEEVS 858
            |.:|.||.|::       ..|...::|.:..  ||..|...|:|...:.|.:.|..|      |.
Zfish   692 LLVVPILVVLI-------IILLYVFKRDSLKRFLKGCPSIRKRPTNAANGSSNTPSN------VQ 743

  Fly   859 LDGSSKLVYANQT 871
            .:|::....|.|:
Zfish   744 ANGNTTRASAPQS 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	18/49 (37%)
		Reprolysin	270..473	CDD:279729	71/208 (34%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	70/206 (34%)
		Disintegrin	488..562	CDD:278623	36/73 (49%)
		ACR	566..713	CDD:214743	43/148 (29%)
zgc:174164	NP_001107911.1	Pep_M12B_propep	44..156	CDD:279848	17/47 (36%)
		Reprolysin	203..395	CDD:279729	71/208 (34%)
		ZnMc_adamalysin_II_like	203..393	CDD:239797	70/206 (34%)
		Disintegrin	412..485	CDD:278623	36/73 (49%)
		ADAM_CR	489..604	CDD:285688	36/127 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579579
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850