Protein Alignment mmd and Adam22

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: XP_038964489.1
• Gene: Adam22 / 57033
• RGDID: 1585016
• Length: 977
• Species: Rattus norvegicus
• Alignment Length: 1050
• Identity: 298/1050 - (28%)
• Similarity: 453/1050 - (43%)
• Gaps: 234/1050 - (22%)

  Fly    15 LCVFVT-------SAGEADYTLDDSFWNEESPVGEVERLLKEYRQNQ---ELVRRIGGHYYQIIY 69
            |||..|       .||:|..        .|...|:..|.|:  ||:.   .|:.|:||.
  Rat    12 LCVLGTYPLARCGRAGDASL--------RELERGDGNRFLE--RQSTVPLRLIYRLGGE------ 60

  Fly    70 PVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNS 134
              ....||::....|              .|.|   ||...|..:.|..:.||...|.||:.||.
  Rat    61 --DETQHEQLNTRVR--------------GDPG---GRQPTHVDKASFRVDAFGTSFILDVLLNH 106

  Fly   135 QLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIH 199
            :|||....::|...||.:|:....  |||||.|.::..|.:..|..||:|:.|:.:.||.|::|.
  Rat   107 ELLSSGYVERHIEHGGKVVENKGG--EHCYYQGQIRGNPASFVALSTCHGLHGMFYDGNHTYLIE 169

  Fly   200 PFYGGDLSKHP--HVIFEARTKANKGCANSGNLDSW------------------RLSRRTKHLSA 244
            | ...::|:..  |.::::|..       ...||..                  ||.||.:.|.
  Rat   170 P-EENEMSQESQFHSVYKSRLL-------EFPLDDLPSEFQRINITAPQFTLKPRLKRRKRQLL- 225

  Fly   245 GVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHD---AIQVANIAD 306
                           |..|:|.|.|||||..|:.|..||.|.    |..|::.   |..|.|:||
  Rat   226 ---------------RFPRNVEEETKYIELMIVNDHLMFKKH----RLSVVYTNTYAKSVVNMAD 271

  Fly   307 LYFR-TLNTRVSVVYIETW-GKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFA 369
            :.:: .|.||:.:|.:||| ..|:..|  |::....:..|..| .|:..:.:.|...|.:|..|.
  Rat   272 VIYKDQLKTRIVLVAMETWAADNKFAI--SENPLVTLREFMKY-RRDFIKEKADAVHLFSGSQFE 333

  Fly   370 GGEAGMAVPETVCTPRAVGISVDVNVY-EPHLLAGTMAHMIGHNIGMGHDDGR---EECFCRD-W 429
            ...:|.|....:|:....|   .||.: :..|:|.|:|..:.||||:..|..:   .||.|.| |
  Rat   334 SSRSGAAYIGGICSLLRGG---GVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTW 395

  Fly   430 HGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEECD 494
            .||||..:    ....|.||::|:.::|.|.|.:|.|.||.|||:::.....|||..:|..||||
  Rat   396 SGCIMGDT----GYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECD 456

  Fly   495 CGTFEECALD--QCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQ 557
            |||..||||:  :||.  .|.|..::||:.|.||.:|:.:|...:||::.|:||:.|.|.|...|
  Rat   457 CGTPAECALEGAECCK--KCTLTQDSQCSDGLCCKKCKFQPLGTVCREAVNDCDIREICSGNSSQ 519

  Fly   558 CPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHC 622
            |..:|.|.:|..|    .|..|.||.|.|.|...||:.|||...:|:||.|||:.|.:|:..|:|
  Rat   520 CAPNVHKMDGYSC----DGTQGICFGGRCKTRDRQCKYIWGQKVTASDRYCYEKLNIEGTEKGNC 580

  Fly   623 GRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSY 687
            |:| .:.:.:|...:|.||.|.|.:....|....:|...:.|::..:|:...|  :.|.|.....
  Rat   581 GKD-KDTWTQCNKRDVLCGFLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNC--SGGHVKLEED 642

  Fly   688 PEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGN 752
            .:.|.|:||||||..::||...|:.: ...:.:.|.:|..|..||.:|||:|..:|.|:..|.|.
  Rat   643 VDLGYVEDGTPCGPQMMCLEHRCLPM-ASFNFSTCLSNKAGTVCSGNGVCSNELKCVCNRHWTGA 706

  Fly   753 DCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLA 817
            ||.:             ..|.|    :..:|....|......|   .||:.:|...:.:....|.
  Rat   707 DCGT-------------HFPHN----DDAKTGITLSGNGVAGT---NIIIGIIAGTILVLALILG 751

  Fly   818 VC------YRRKTTTLKYDPPYSKKP-IAKSY------GGAATAPN------------------- 850
            :.      ||.:....:.|  |.||| ...|:      ||:|.:.:
  Rat   752 ITAWGYKNYREQRQLPQGD--YVKKPGDGDSFYSDFPPGGSADSASSSKKRSAFLSHFQISTCSI 814

  Fly   851 -HHSV-EEVSL--DGSSKLVYA--------------------------NQTGFRDKGIHGRRY-- 883
             |:|: :.:||  ..|:.|.::                          ...|...|.|.|:|:
  Rat   815 THYSISQNISLFCSRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNVGGNKKKIRGKRFRP 879

  Fly   884 -TTCGEDDQSHAEKG-ILKKHGYGLVHGEQLKDKWGDDN-QSDNLELITQDG------TLA---- 935
             :...|.:....|.| .|.:...|:..|       |.|: |:.:|:..||||      ||:
  Rat   880 RSNSTEREPQAPEPGHSLAQTSPGISPG-------GSDSPQTGSLDHSTQDGQHQENRTLSPAKS 937

  Fly   936 -STSGGAAAS 944
             |:|.|:.||
  Rat   938 PSSSTGSIAS 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	37/111 (33%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	68/210 (32%)
		Disintegrin	488..561	CDD:459709	33/74 (45%)
		ACR	566..713	CDD:214743	50/146 (34%)
Adam22	XP_038964489.1	Pep_M12B_propep	70..185	CDD:460254	40/134 (30%)
		Reprolysin	236..435	CDD:426256	69/212 (33%)
		Disintegrin	450..523	CDD:459709	33/74 (45%)
		ACR	527..668	CDD:214743	50/147 (34%)