DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam18

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_038950722.1	Gene:	Adam18 / 57029	RGDID:	620405	Length:	751	Species:	Rattus norvegicus

Alignment Length:	801	Identity:	211/801 - (26%)
Similarity:	330/801 - (41%)	Gaps:	133/801 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LILIIAQLCVFVTSAGEADYTLDDSFWNEESPVGEVERLLKEYRQNQELVRRIGGHYYQIIYPVQ 72
            |..|:|:|.:.:.           :..|..||.|                  :|..:.|.|...:
  Rat     3 LFFILAELAMLLA-----------ALVNSGSPTG------------------MGLPWIQEINRTK 38

  Fly    73 LR-HHEKMGISTRE-------VSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLD 129
            |: .:.||.:...:       :::|:..:..:..|..|           :.|.:|......:.|.
  Rat    39 LKAPNYKMHVLAADSEGIWLHITVPQKIEPFKGGDSEG-----------KVSYVITIDGKPYFLH 92

  Fly   130 LELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNE 194
            |. |...||.|.....|:..|.|...:.|.:.||:|.|.|.:.|.:......|:|:.|.:.:.|.
  Rat    93 LR-NYSFLSRNFSVYAYNETGSLYSDSPHFLAHCHYRGYVGEVPDSIVTLSLCSGLRGFLQLENT 156

  Fly   195 TFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVG 259
            ::.|.|....  ::..|::::.::.::...||...:  |:.||:               |..|..
  Rat   157 SYGIEPLESS--ARFEHIVYQMKSNSSTLAANYSCI--WQTSRQ---------------LDKGHF 202

  Fly   260 R--NKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIE 322
            |  :|.|.:...|.::..|||.|.:||.. ||....|.....|:..:.:..|..||..|.:..:|
  Rat   203 REQDKNDSQLLPKSLKLHIIVGKFLFDYM-GSDIMAVTQKIFQIIGLVNTMFTQLNLNVVLASLE 266

  Fly   323 TWG-KNQAVIDG-SKDISKAISNF-NDYTSRNLFQIERDTTQLL--------TGETFAGGEAGMA 376
            .|. |||...|| :.||.:.:..: .||    |.....:.|.||        .|.|..|.....:
  Rat   267 LWSDKNQISTDGNASDILQRLLGWKRDY----LTPQSNEITHLLIYRKHLKYIGATSPGELCNES 327

  Fly   377 VPETVCT-PRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVG 440
            ....|.| |..:|:..         |:..:..:||.:||:.:|| .:.|.| ....|||....:.
  Rat   328 YVAGVGTYPEDIGLEG---------LSMVITQLIGLHIGLTYDD-VDNCSC-PRAPCIMQPEALS 381

  Fly   441 QENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRN-CGNKVVEEDEECDCGTFEECALD 504
            ...::  .||.||..||..........||.:..|.::.::: |||.:||..||||||...||...
  Rat   382 SSGMK--TFSNCSVHDYTHYASKLDMQCLGDLSNVLQPKQSVCGNGIVEGSEECDCGNETECQFK 444

  Fly   505 QCCDGITCKLKSEAQCASGACC-DQCRLRPKDYICRDS-NNECDLPEYCDGEIGQCPSDVFKKNG 567
            :||:..|||||..|||.||.|| .:|.|......||.: :.|||..|||||....|..|.|..:|
  Rat   445 ECCNHETCKLKGSAQCGSGTCCTPKCELSAAGTPCRKAVDPECDFTEYCDGSSSHCVPDTFALDG 509

  Fly   568 SPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIK 632
            ..|.|.    |.||:.|.|..|:.||.:::|.|...|...|:|:.||:.....:|. ..|.:.:.
  Rat   510 HLCRLG----SAYCYNGRCQALNDQCVSLFGKGSQGASYACFEKVNSQRENLANCD-SKNSYSLP 569

  Fly   633 CEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNS-YPEHGLVKDG 696
            |..::|.||.|.|....:...:.....|||....|:      |.:....:...| ..::..|.||
  Rat   570 CGQKDVLCGKLACFRPNKNYKSSTQSVLYSYVHGSV------CLSIPPGLSMRSDGKDNAYVADG 628

  Fly   697 TPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVV--- 758
            |.||..:.|:|.:|    ..|:.|....|: ..:|..:|:|.|...|.|...:...||:..:
  Rat   629 TVCGPQMYCINGSC----KEVNFTGNDCNA-AKKCKGNGICNNFGHCQCFPDYRPPDCNLQIGSP 688

  Fly   759 --------LLTT--ALPTEAL 769
                    ||.|  ||.|:.|
  Rat   689 GGSIDDGNLLRTDSALATKRL 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	25/106 (24%)
		Reprolysin	270..473	CDD:279729	57/214 (27%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	57/212 (27%)
		Disintegrin	488..562	CDD:278623	36/75 (48%)
		ACR	566..713	CDD:214743	41/147 (28%)
Adam18	XP_038950722.1	Pep_M12B_propep	59..174	CDD:396235	28/128 (22%)
		ZnMc_adamalysin_II_like	215..408	CDD:239797	55/210 (26%)
		Disintegrin	428..503	CDD:395147	36/74 (49%)
		ACR	507..645	CDD:214743	41/152 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339784
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850