DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam17

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_064702.2	Gene:	Adam17 / 57027	RGDID:	620404	Length:	827	Species:	Rattus norvegicus

Alignment Length:	845	Identity:	178/845 - (21%)
Similarity:	265/845 - (31%)	Gaps:	285/845 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 TSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHC-----YYHGTVKDYPG 174
            |.|...|....|:|.|..:::..|.|::.       .:||| :.:.|:.     ::.|.|...|.
  Rat    68 TLLTFSALKRHFKLYLTSSTERFSQNLRV-------VVVDG-KEESEYSVKWQDFFSGHVVGEPD 124

  Fly   175 ASAAFHT-CNGVSGVIHIGNETFVIHPF--YGGDLSKHPHVIFE-------ARTKANKGCANSGN 229
            :....|. .:.|:..|:.....:.|.|.  :..|......::::       :|.::.|.|... |
  Rat   125 SRVLAHIGDDDVTVRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKDFSRLQSPKVCGYL-N 188

  Fly   230 LDSWRLSRRTKHLSAGVAGVVEEILQAG-VGRNKRD--VREATKYIE--------TAIIVDKAMF 283
            .||                  ||:|..| :.|...:  ||...:..|        ..::|....|
  Rat   189 ADS------------------EELLPKGLIDREPSEEFVRRVKRRAEPNPLKNTCKLLVVADHRF 235

  Fly   284 DKRNG----STRAEVIHDAIQVANIADLYFRT-------LNTRVSVVYIETWGKNQAVIDGSKDI 337
            .|..|    ||....:.:.|.  .:.|:|..|       ....|.:..|......|.|..|.:..
  Rat   236 YKYMGRGEESTTTNYLIELID--RVDDIYRNTSWDNAGFKGYGVQIEQIRILKSPQEVKPGERHF 298

  Fly   338 SKAISNFNDY-----TSRNLFQIERDTTQ---------LLTGETFAGGEAGMAVPETVCTPRA-- 386
            :.|.|..|:.     ....|.|...|..:         |.|.:.|..|..|:|.   |.:|||
  Rat   299 NMAKSFPNEEKDAWDVKMLLEQFSLDIAEEASKVCLAHLFTYQDFDMGTLGLAY---VGSPRANS 360

  Fly   387 -VGI--------SVDVNVYEPHLLAGT---------------MAHMIGHNIGMGHD-DGREECFC 426
             .|:        .|..|:|....|..|               ..|.:|||.|..|| ||..||..
  Rat   361 HGGVCPKAYYNPGVKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAP 425

  Fly   427 RDWHG--CIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEE 489
            .:..|  .:|....|..::.....||.|||:.....:.:....|...:.|::     |||..|:|
  Rat   426 NEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKV-----CGNSRVDE 485

  Fly   490 DEECDCGTFEECALDQCCDGITCKLKSEAQCA--SGACCDQCRLRPKDYICRDS-NNECDLPEYC 551
            .||||.|.. ....|.||:. .|.||...||:  :..||..|:.......|::: |..|....||
  Rat   486 GEECDPGIM-YLNNDTCCNS-DCTLKPGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYC 548

  Fly   552 DGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKG 616
            .|...:||..                                      |.:..|..|.:.
  Rat   549 TGNSSECPPP--------------------------------------GDAEDDTVCLDL----- 570

  Fly   617 SINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQ 681
               |.|.......:.|.|.|...|.   |.|.:.                       .||.
  Rat   571 ---GKCKAGKCIPFCKREQELESCA---CADTDN-----------------------SCKV---- 602

  Fly   682 VGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCD 746
                             |..|   |:..||   |:||     |..:.|...:...||..   |||
  Rat   603 -----------------CCRN---LSGPCV---PYVD-----AEQKNLFLRKGKPCTVG---FCD 636

  Fly   747 MGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKK-----ETPYGTSDQNRIST----LTMVIIL 802
            |..                           |.||:     |..:...||..|:|    |...|:.
  Rat   637 MNG---------------------------KCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVG 674

  Fly   803 TVIV-KCVF-ISFATLAVCYRRKTTTLKYDPPYSKKPIAKSYGGAATAPNHHSVEEV--SLDGSS 863
            :|:| ..:| |.|:.|..|..:|              :.|.|...:..  |||..|:  |:|.:|
  Rat   675 SVLVFSLIFWIPFSILVHCVDKK--------------LDKQYESLSLF--HHSNIEMLSSMDSAS 723

Fly 864 863
Rat 724 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	21/105 (20%)
		Reprolysin	270..473	CDD:279729	58/264 (22%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	58/262 (22%)
		Disintegrin	488..562	CDD:278623	25/76 (33%)
		ACR	566..713	CDD:214743	18/146 (12%)
Adam17	NP_064702.2	Pep_M12B_propep	52..167	CDD:396235	21/106 (20%)
		Cysteine switch. /evidence=ECO:0000250	182..189		2/7 (29%)
		ZnMc_TACE_like	223..477	CDD:239798	58/258 (22%)
		DISIN	484..559	CDD:214490	25/114 (22%)
		ADAM17_MPD	581..642	CDD:406977	25/148 (17%)
		Crambin-like	603..671		25/108 (23%)
		SH3-binding. /evidence=ECO:0000255	731..738
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..827
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920