Protein Alignment mmd and Adam15

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: XP_008759425.1
• Gene: Adam15 / 57025
• RGDID: 620402
• Length: 875
• Species: Rattus norvegicus
• Alignment Length: 693
• Identity: 212/693 - (30%)
• Similarity: 331/693 - (47%)
• Gaps: 77/693 - (11%)

  Fly   115 TSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGG------YLVDGNR-----HDIEHCYYHGT 168
            |.:|........|:.|||:.:.....:||....|.|      |..||.|     |.:|:|.|.|.
  Rat    59 TEVLQTGLPETLRIGLELDGENHILELQQNRDLVPGRPTLVWYQPDGTRMVSEGHSLENCCYRGR 123

  Fly   169 VKDYPGASAAFHTCNGVSGVIHIGNE---TFVIHPFYGGDLSKHPHVIFEARTKANKG--CANSG 228
            |:..|.:..:...|:|:.|::.:..|   |..:.|   |||.: |.::...:.....|  ||
  Rat   124 VQGRPSSWVSLCACSGIRGLVVLSPERSYTLELGP---GDLQR-PLIVSRIQDLLLPGHTCA--- 181

  Fly   229 NLDSWR----------LSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMF 283
              .||.          |.....||..     |....|:...|.||||...||.:|..|:.|.:
  Rat   182 --PSWHAFVPTEAAPDLLLEQHHLRR-----VRRQTQSPDPRLKRDVVTETKIVELVIVADNS-- 237

  Fly   284 DKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYT 348
            :.|......::::..::||.:.|.:|:.||.||::|.:|.|.:.. :|:.|.:.:..:.||..:.
  Rat   238 EVRKYPDFQQLLNRTLEVALLLDTFFQPLNVRVALVGLEAWTQRD-LIEMSSNPAVLLDNFLRWR 301

  Fly   349 SRNLF-QIERDTTQLLTGETFAGGEAGMAVPETVCTPR-AVGISVDVNVYEPHLL--AGTMAHMI 409
            ..:|. ::..|:.||:|..:|:|...|||:..::|:|. :.|:::|   :...:|  |.::||.:
  Rat   302 RTDLLPRLPHDSAQLVTVTSFSGPMVGMAIQNSICSPDFSGGVNMD---HSTSILGVASSIAHEL 363

  Fly   410 GHNIGMGHDDGREECFC---RDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLN 471
            ||::|:.||.....|.|   .....|||..|   .:.:....||.||:.....||..|.|.||..
  Rat   364 GHSLGLDHDSPGNSCPCPGPAPAKSCIMEAS---TDFLPGLNFSNCSRWALEKALLDGMGSCLFE 425

  Fly   472 -KPNEIELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCAS-GACCDQCRLRPK 534
             .|:...:...|||..|:..|:||||..:||. |.|||..||:|:..||||| |.||..|:|:|.
  Rat   426 WPPSRAPMSSLCGNMFVDPGEQCDCGFPDECT-DPCCDYFTCQLRPGAQCASDGPCCQNCKLQPA 489

  Fly   535 DYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGY 599
            .:.||...::|||||:|.|:..|||.|:...:|.||...:    ..|..|.|.:.:.||:::||.
  Rat   490 GWQCRLPTDDCDLPEFCLGDSSQCPPDIRLGDGEPCASGE----AVCMHGRCASYTRQCQSLWGP 550

  Fly   600 GGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGI-DQLYSR 663
            |...|...|.:..|::|:..|.|||..:..|:.|...:..||.|||:.|..||:...: |||  .
  Rat   551 GAQPAAPLCLQTANTRGNAFGSCGRSPSGSYMPCNLRDAICGQLQCQWGRNQPLLGSVQDQL--S 613

  Fly   664 TIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTC--VSLFPHVDQTKCPANS 726
            .::...|.:..|......:| |...:..|...||.||..|:|:...|  |.|   :...:|.:
  Rat   614 EVLEANGTQLNCSWVDLDLG-NDVAQPLLALPGTACGPGLVCIGHRCQPVDL---LGAQECRS-- 672

  Fly   727 QGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEAL 769
               :|..||||.::..|.||.||...||.:.:..|::|.|..|
  Rat   673 ---KCHGHGVCDSSRHCHCDEGWAPPDCMTQLRATSSLTTGLL 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	31/112 (28%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	59/207 (29%)
		Disintegrin	488..561	CDD:459709	37/73 (51%)
		ACR	566..713	CDD:214743	45/149 (30%)
Adam15	XP_008759425.1	Pep_M12B_propep	67..147	CDD:460254	22/79 (28%)
		ZnMc_adamalysin_II_like	226..424	CDD:239797	58/206 (28%)
		DISIN	443..516	CDD:214490	37/73 (51%)
		ACR	521..662	CDD:214743	44/147 (30%)