Protein Alignment mmd and Adam3a

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_064698.1
• Gene: Adam3a / 57021
• RGDID: 621469
• Length: 740
• Species: Rattus norvegicus
• Alignment Length: 780
• Identity: 190/780 - (24%)
• Similarity: 323/780 - (41%)
• Gaps: 131/780 - (16%)

  Fly   114 RTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGY-----LVDGNRHDIEHCYYHGTVKDYP 173
            :.:.:|:.....:.|.||..|.|....:...|..:|..     ||.      .||:|.|...:.|
  Rat    47 QVTYVIRIEGKAYTLQLEKQSFLHPHFVTNLHNKLGTLQPYFSLVK------SHCFYQGHAVEIP 105

  Fly   174 GASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEAR------TKANKGCANS-GNLD 231
            .::....||:|:.|::.:.|.|:.|.|.......:  |:::|.:      :...:...|| ....
  Rat   106 ASTVTLSTCSGLRGLLQLENVTYGIEPLESSTTLE--HILYEIQNHKIDYSPLKENYTNSQDESG 168

  Fly   232 SWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIH 296
            |:|:             :|:.:..:.....||       .:...||:||.||| ..||.......
  Rat   169 SYRI-------------LVKPLKSSNSKLRKR-------ILTVKIIMDKGMFD-HVGSEVGVATQ 212

  Fly   297 DAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQ 361
            ..:|:..:.:..|..|...|.:..:|.|.:... |:.:.|..:.:..|..:|.:.:.|..::.|.
  Rat   213 KVVQMFGLINTMFSQLKMTVMLNSLEIWSEENK-IETNGDADEVLQRFLLWTHKEMPQTTKEITY 276

  Fly   362 LL--------TGETFAGGEAGMAVPETVCTPR-AVGISVDVNVYEPHLLAGTMAHMIGHNIGMGH 417
            ||        .|.|:    .|||     |.|: ..||::..........|..::.::|.|:|:.:
  Rat   277 LLLYKDHPDYVGATY----HGMA-----CNPKFTAGIALHPKTLGVEGFAIVLSQLLGINLGLTY 332

  Fly   418 DDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIEL---- 478
            || ...||||. ..|||..|.:..|.::  .||.||..::..........||| |..|.|:
  Rat   333 DD-IYNCFCRG-STCIMNPSAIHSEGIK--VFSSCSMDEFRQLASQPDLDCLL-KTQETEVVALP 392

  Fly   479 --RRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQ--CRLRPKDYICR 539
              .:.|||.::|..|:||||..|.|:..:||....|.|.|:|:|.||||||:  |::..:..:||
  Rat   393 QAAKVCGNYILEPPEQCDCGPAERCSHKKCCKSEDCTLLSDAECGSGACCDKRTCKIAERGRLCR 457

  Fly   540 DSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAA 604
            .|.::||.||:|:|....|.:|:...:..||    ...:.|||:|.|.....||..::|......
  Rat   458 KSTDQCDFPEFCNGTSEFCVADIKAADLEPC----NNETAYCFKGVCQDRDRQCTDLFGKYAKGP 518

  Fly   605 DRQCYEQFNSKGSINGHC-GRDANEHYIKCEPENVQCGTLQCKDGERQPV-NDGIDQLYSRTIIS 667
            :..|.::.|.:....|:| ||        |....:.||...|.....:.| .|..|..|:    .
  Rat   519 NYVCAQEVNLQNDKFGNCHGR--------CNYSALFCGKAVCYWSFAELVKTDVFDVQYT----Y 571

  Fly   668 IKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECS 732
            :.||  .|.:...:|.::...:...|:|||.||:..:|....|:.:.......:|.|:.   :|.
  Rat   572 LGGQ--VCVSAHLRVRNDETKDDTYVRDGTICGNGQVCYRGECLRVHVLRGDRECEADD---KCQ 631

  Fly   733 EHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEA------LPTPENTIKMEKKETPYGTSDQN 791
            .||:|.|.|.|.|:.|:...:|.    :|.:.|..:      ||..::|..:.|:.   ||..:.
  Rat   632 GHGICNNQNNCQCEAGFAPPECD----MTPSSPGGSMDDGFWLPLDKSTPLVIKRP---GTQYKK 689

  Fly   792 RISTLTMVIILTVIVKCVFISFATLAVCYRRKTTTLKYDPPYSKKPIAKSYGGAATAPNHHSVEE 856
            .:.....|.:..:||..:.:                      .|:.|:|.:|......:..|:.|
  Rat   690 GLLISFYVFLPFLIVTAIMV----------------------VKQNISKMFGQGEEEFSEGSISE 732

  Fly   857  856
              Rat   733  732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	24/104 (23%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	53/209 (25%)
		Disintegrin	488..561	CDD:459709	32/74 (43%)
		ACR	566..713	CDD:214743	36/148 (24%)
Adam3a	NP_064698.1	Pep_M12B_propep	27..144	CDD:460254	24/104 (23%)
		ZnMc_adamalysin_II_like	193..381	CDD:239797	52/202 (26%)
		Disintegrin	404..479	CDD:459709	32/74 (43%)
		ACR	483..615	CDD:214743	36/149 (24%)
		EB	601..650	CDD:460294	15/51 (29%)