DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mmd and Adam1a

DIOPT Version :9

Sequence 1:NP_001285311.1 Gene:mmd / 32561 FlyBaseID:FBgn0259110 Length:1484 Species:Drosophila melanogaster
Sequence 2:NP_064463.1 Gene:Adam1a / 56777 RGDID:621467 Length:789 Species:Rattus norvegicus


Alignment Length:886 Identity:231/886 - (26%)
Similarity:351/886 - (39%) Gaps:199/886 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LILIIAQLCVFVTSAGEADYTLDDSF----------WNEESPVGEVERLLKEYRQNQELVRRIGG 62
            ||.:.:.||       :.....|.|:          ...:.|.|:|..:|....|.|.|...:.|
  Rat    60 LIFLPSTLC-------DLGSVYDSSYETVIPERLPGQGSDDPGGKVSYVLLMQGQKQLLHLEVKG 117

  Fly    63 HYYQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFR 127
            ||.:..:||...||   ||..:||                                         
  Rat   118 HYSERNFPVYSYHH---GILGQEV----------------------------------------- 138

  Fly   128 LDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIG 192
                   .|||                      :.|:|.|.::..||:..:...|:|:.||: |.
  Rat   139 -------PLLS----------------------QACHYEGHIEGVPGSFVSVSICSGLRGVL-IK 173

  Fly   193 NET-FVIHP-FYGGDLSKHPHVIFEARTKANKG--CANSGNLDSWRLSRRTKHLSAGVAGVVEEI 253
            .|| :.|.| .:..|..   |:::   |.|::.  ..|....||...|.:.:..|.     .:|:
  Rat   174 EETAYGIEPLLFSTDFE---HILY---TMAHQPVVLCNVTPTDSLGDSSQRQGSSK-----TDEL 227

  Fly   254 LQAGVGRNKRDVREATKYIETAIIVDKAMFDK--RNGSTRAEVIHDAIQVANIADLYFRTLNTRV 316
            |...      |:....||:|..::|:...|..  .:.:|..:.:.|.|.:||   .:.|.:||.|
  Rat   228 LALS------DLWSHAKYVEMFVVVNHQRFQMWGSDVNTTVQAVVDIIALAN---SFTRGINTEV 283

  Fly   317 SVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLF-QIERDTTQLLTGETFAGGEAGMAVPET 380
            .:|.:|.|.:... |:...|:...:.|||.:....|. ::..|...|:.|.. .|...|.|..:.
  Rat   284 VLVGLEIWTEGDP-IEVPVDLQATLRNFNLWRQEKLMGRVRHDVAHLIVGHR-PGANEGQAFLDG 346

  Fly   381 VCTPRAVGISVDVNVYEPH---LLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQE 442
            .|:.   |.:..|..:...   |.|..|||.:|||:|:.||  |..|.|...|.|:|.::|....
  Rat   347 ACSG---GFAAAVEAFHHEDVLLFAALMAHELGHNLGIRHD--RPGCTCGPKHLCLMHETISKTS 406

  Fly   443 NVQPYKFSECSKKDYIDALRTGHGLCLLNKP-NEIELRR--NCGNKVVEEDEECDCGTFEECALD 504
            .     ||.||...::..|....|.|||::| ::...||  :|||.||||.||||||  ..|...
  Rat   407 G-----FSNCSSDHFLRFLHDHRGACLLDRPWHQSHKRRDAHCGNGVVEESEECDCG--NACDSH 464

  Fly   505 QCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSP 569
            .||:. ||.||..|||:.|.||.:|..:.|..:||.:.:.|||||||:|..|:||::.:.::|:.
  Rat   465 PCCEP-TCTLKVGAQCSEGLCCYKCTFKKKGTLCRPAEDVCDLPEYCNGITGECPANSYMQDGTQ 528

  Fly   570 CGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGR--DANEHYIK 632
            |....     ||..|.|.....||..|:||...:|..:||...|:|.:..|:||.  .||..|..
  Rat   529 CDRIY-----YCSGGLCKNPDKQCARIYGYPARSAPEECYISVNTKANRFGNCGHPTSANLKYEA 588

  Fly   633 CEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGT 697
            |..|::.||.|.|.|....|   .:..|:|  ::.|...:..|.:... ......|::|.|:.||
  Rat   589 CSNEDIFCGKLVCTDVRYLP---QVKPLHS--LLQIPYGDDWCWSMDA-YNVTDIPDYGDVQGGT 647

  Fly   698 PCGDNLICLNQTCVSLFPHVD-QTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSS----- 756
            .|....:|:...|..   |.. |..|.....   |..:|||.|...|.||.|:...||||     
  Rat   648 YCAPKKVCMESICTG---HATLQYDCHPQEM---CHGNGVCNNFKHCHCDAGFSPPDCSSGGNGG 706

  Fly   757 ------VVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVI---ILTVIVKCVFIS 812
                  |          ..|...|.......|:|....:...|:...:|:   |..:::.|..:.
  Rat   707 SVDSGPV----------GKPADRNLSLFGVGESPDSRMEDEEINLKVVVLVVPIFLIVLLCCLML 761

  Fly   813 FATLAVCYRRKTTTLKYDPPYSKKPIAKSYGGAATAPNHHS 853
            .|.|                :|:...|.|.|.::|..:..|
  Rat   762 IAYL----------------WSEVQEAVSPGSSSTTSSSES 786

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mmdNP_001285311.1 Pep_M12B_propep 106..213 CDD:279848 19/108 (18%)
Reprolysin 270..473 CDD:279729 59/208 (28%)
ZnMc_adamalysin_II_like 270..471 CDD:239797 58/206 (28%)
Disintegrin 488..562 CDD:278623 36/73 (49%)
ACR 566..713 CDD:214743 42/148 (28%)
Adam1aNP_064463.1 Pep_M12B_propep 79..194 CDD:396235 37/191 (19%)
Reprolysin 238..432 CDD:396140 59/208 (28%)
DISIN 450..522 CDD:214490 36/74 (49%)
ACR 524..660 CDD:214743 41/146 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 273 1.000 Inparanoid score I2908
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11905
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X50
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.070

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