DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and adam11

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_021335948.1	Gene:	adam11 / 567145	ZFINID:	ZDB-GENE-070808-3	Length:	788	Species:	Danio rerio

Alignment Length:	855	Identity:	265/855 - (30%)
Similarity:	403/855 - (47%)	Gaps:	157/855 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IIAQLCVFVTSAGEADYTLDDSFWNEES--------PVGEVERLLKEYRQNQELVRRIGGHYYQI 67
            :||:|.|   :|..:....|.:.|..|:        |    :|||:.....:||
Zfish    13 VIARLAV---TAWGSSTKRDGAEWGRENAYTVEHALP----QRLLQRTDAEEEL----------- 59

  Fly    68 IYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLEL 132
                   .|..:|..|:.             |..|.:    ..|..:.:.|:|||...|.|||||
Zfish    60 -------PHGHLGTLTKT-------------DGDGTH----PIHLAQITFLVKAFGIPFVLDLEL 100

  Fly   133 NSQLLSPNIQQKHYH--------VGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVI 189
            |..|||.|..::|:.        :||          |||||||.|:..|.:.||..||:|:.|:.
Zfish   101 NHDLLSSNYVERHFEKDGQSFQTLGG----------EHCYYHGHVRGVPRSWAALSTCHGLQGMF 155

  Fly   190 HIGNETFVIHPFYGGDLSKHP---------------HVIFEAR--------TKANKGCANSGNLD 231
            ..||.::.|.|.:......|.               ||::...        :.:.:..::|...:
Zfish   156 SDGNFSYGIEPLHNSSDQTHDSKIIEEDASIKDANIHVVYRMADIRLMPHFSGSTRNSSDSDINN 220

  Fly   232 SWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREA-------TKYIETAIIVDKAMFDKRNGS 289
            .:.:|..|..|.          |..|:.|.||.||..       |||:|..::.|..:|.:...|
Zfish   221 DYPVSMETSQLE----------LTDGLRRAKRQVRRGPRTVQSETKYVELLVVNDYDLFVQMRRS 275

  Fly   290 TRAEVIHDAIQVANIAD-LYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLF 353
            : .:..:.|..|.|:|| :|...||||:.:|.:||| ..|.::....|....:.:|..|...|:.
Zfish   276 S-PQTRNFAKAVVNMADAIYKEQLNTRIVLVAMETW-STQNMVSVGDDPLVTLRDFMKYRKENIK 338

  Fly   354 QIERDTTQLLTGETFAGGEAGMAVPETVCTP-RAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGH 417
            : :.||..||:|.||....:|.|..|.:|:| |..|::...||..   :|.|:...:|.|:||..
Zfish   339 E-KSDTAHLLSGRTFQSSRSGTAYIEGICSPTRGGGVNEYGNVGP---MAITLCQSLGQNLGMMW 399

  Fly   418 DDGRE---ECFCRD-WHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIEL 478
            :..|.   :|.|.| |.||||..:    ....|.|||.||.::||..|:.|.|.||.||||::..
Zfish   400 NKDRATAGDCRCPDPWLGCIMEDT----GYYLPRKFSRCSIEEYIQFLQQGGGSCLFNKPNKLLD 460

  Fly   479 RRNCGNKVVEEDEECDCGTFEEC--ALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDS 541
            ...|||..||:.||||||:..:|  |...||.  .|.|..:|.|::|.||::|:...:..||||:
Zfish   461 PPECGNGFVEQGEECDCGSQVDCSRAGGACCK--KCTLTHDAMCSNGLCCNRCKYEQRGVICRDA 523

  Fly   542 NNECDLPEYCDGEIGQCPSDVFKKNGSPC--GLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAA 604
            .|:||:||.|.|:..:||.:|.|.:|..|  ||      |.|:.|.|.|...||:|:||:  :||
Zfish   524 VNDCDVPETCSGDSSKCPHNVHKLDGYMCDAGL------GRCYGGRCKTRDAQCQALWGH--NAA 580

  Fly   605 DRQCYEQFNSKGSINGHCGRDANEH-YIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISI 668
            ||.|||:.|.:|:..|:||:|::.| :|:|..::|.||.|.|.:...:|....:....:...|..
Zfish   581 DRMCYEKLNIEGTERGNCGQDSSSHNWIQCNKQDVLCGFLLCTNITVKPRYGDLHGESTSLTIYH 645

  Fly   669 KGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTC--VSLFPHVDQTKCPANSQGLEC 731
            :.:..:|:  .|........:.|.|:||||||.|::||:..|  |:.|   :.:.||.:|..|.|
Zfish   646 QNKYLDCR--GGHAVLEDGTDLGYVEDGTPCGPNMMCLDHRCLPVTTF---NLSSCPGSSFSLVC 705

  Fly   732 SEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTL 796
            |:||.|:|..:|.||..:.|.|||..         :.:|.|:.....||.:.|.||:  ..|.::
Zfish   706 SDHGTCSNEVKCICDSDYTGKDCSVY---------DPIPDPQPPDGPEKYKGPSGTN--IIIGSI 759

  Fly   797 TMVIILTVIV 806
            ...|:|..||
Zfish   760 AGAILLAAIV 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	40/129 (31%)
		Reprolysin	270..473	CDD:279729	70/208 (34%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	69/206 (33%)
		Disintegrin	488..562	CDD:278623	32/75 (43%)
		ACR	566..713	CDD:214743	52/151 (34%)
adam11	XP_021335948.1	Pep_M12B_propep	68..195	CDD:307618	44/153 (29%)
		Reprolysin	256..455	CDD:307535	70/208 (34%)
		Disintegrin	470..543	CDD:306668	32/74 (43%)
		ACR	547..688	CDD:214743	51/150 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I8993
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7614
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2271
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0002073
OrthoInspector	1	1.000	-	-		otm25091
orthoMCL	1	0.900	-	-		OOG6_103986
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860