DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam21

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_065063.1	Gene:	Adam21 / 56622	MGIID:	1861229	Length:	729	Species:	Mus musculus

Alignment Length:	765	Identity:	217/765 - (28%)
Similarity:	336/765 - (43%)	Gaps:	132/765 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 ISTREVSLP-KPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNI--- 141
            :|:.||.:| |...|.         ||.....:...||:.....|.  :.:.:...|:|.:|
Mouse    42 LSSPEVVIPLKVTSRA---------RGAKNSEWLSYSLVFGGRRHV--VHMRVKKLLVSTHIPVL 95

  Fly   142 --QQKHYHVGGY-LVDGNRHDIEHCYYHGTVKDYPGASAAFHTCN-GVSGVIHIGNETFVIHPFY 202
              .::|..:..| .|..:      |||||.|:....:..||..|| |:.||:.:...::.|.|.
Mouse    96 TYTEEHTPLSDYPFVPSD------CYYHGYVEGALESLVAFSACNGGLQGVLQMNGFSYEIEPI- 153

  Fly   203 GGDLSKH----PHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKR 263
                 ||    .|:::....       |.........|...|.|.....| |||..::.:.:|..
Mouse   154 -----KHSSTFEHLVYTLNN-------NKTQFPPMLCSLTEKRLLYQPFG-VEEAKKSAMKQNYG 205

  Fly   264 DVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQ 328
            .:.....::|.|::||...|.... ...::|..|.:.|.|:.|..::.|:|.|::|.||.|  |:
Mouse   206 KLWPHMWFLELAVVVDYGFFTNAQ-QNLSKVRGDVVLVVNMVDSMYKPLDTYVTLVGIEIW--NR 267

  Fly   329 AVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDV 393
            ..:...::|.:.:.:|:.:...:|.|:..|...:....:.. ...|:|....:|.|   .:...|
Mouse   268 GNVLPMENIHQVLEDFSHWKQISLSQVHHDAAHIFIRSSLI-SVLGIAYIAGICRP---PLDCGV 328

  Fly   394 NVYEP---HLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKK 455
            ..::.   .|.|.|:||.:||..||.||:  |.|.|.. .||:|:...|..|     :|:.||
Mouse   329 ENFQGDAWSLFANTVAHELGHTFGMKHDE--ESCSCGK-SGCVMSTFRVPAE-----RFTNCS-- 383

  Fly   456 DYIDALRT--GHGLCLLN--KPNEIELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKS 516
             |.|.::|  ..|.||.|  :|....|.:.|||.:||.:||||||:.:||..|.|| .:.|.|:.
Mouse   384 -YSDFMKTTLNQGTCLYNHPRPGAGFLVKRCGNGMVESEEECDCGSVQECEQDPCC-FLNCTLRP 446

  Fly   517 EAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYC 581
            .|.|:.|.||..|:......:||...|||||||:|:|...|||.|.:.::|.||     |...||
Mouse   447 AAACSFGLCCKDCKFMLLGELCRPKINECDLPEWCNGTSHQCPEDGYVQDGVPC-----GAGAYC 506

  Fly   582 FQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCK 646
            :|..|.....||..|:|.|..:|...||::.|.:|:..||||.|... ::||...:|.||.:.|:
Mouse   507 YQKQCNNHDQQCREIFGKGARSASHNCYKEINLQGNRFGHCGTDGTV-FLKCRMSDVFCGKVHCE 570

  Fly   647 DGE-----RQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICL 706
            :.|     :.|.  .:..:|:..|        .|.:|...:|. ..|:.|.|||||.||...|||
Mouse   571 NVEDIHHPQAPY--VLQNIYANGI--------TCWSTGHCLGM-GVPDVGEVKDGTTCGVGKICL 624

  Fly   707 NQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPT 771
            ::.||||  .|....|...:    |:..|||.|.:.|.||.||....|
Mouse   625 HKKCVSL--SVLSNACLPET----CNRKGVCNNKHHCHCDYGWSPPFC----------------- 666

  Fly   772 PENTIKMEKKETPYG-------TSDQNR--ISTLTMVIILTVIVKCVFIS 812
                     ....||       ||.:.|  |:.|::.:.:..|:.|:.|:
Mouse   667 ---------LHRGYGGSIDSGPTSQKRRVIITVLSITVPVLSILICLLIA 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	28/117 (24%)
		Reprolysin	270..473	CDD:279729	57/209 (27%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	56/205 (27%)
		Disintegrin	488..562	CDD:278623	34/73 (47%)
		ACR	566..713	CDD:214743	50/151 (33%)
Adam21	NP_065063.1	Pep_M12B_propep	55..163	CDD:279848	30/130 (23%)
		Cysteine switch. /evidence=ECO:0000250	176..183		1/6 (17%)
		ZnMc_adamalysin_II_like	212..400	CDD:239797	56/205 (27%)
		Reprolysin	213..402	CDD:279729	57/206 (28%)
		Disintegrin	419..491	CDD:278623	34/72 (47%)
		ACR	495..631	CDD:214743	50/152 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836148
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850