DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam39

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001020551.3	Gene:	Adam39 / 546055	MGIID:	3045694	Length:	756	Species:	Mus musculus

Alignment Length:	882	Identity:	232/882 - (26%)
Similarity:	364/882 - (41%)	Gaps:	223/882 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWINIANLILIIAQLCVFVTSAGEADYTLDDSFWNEESPVGEVERLLKEYRQNQELVRRIGGHYY 65
            :|:.|.|::                      |.|           ||..|.|:..|.
Mouse    33 LWLEILNIL----------------------SSW-----------LLTGYAQHTSLP-------- 56

  Fly    66 QIIYPVQLRHHEKM-GISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLD 129
            :::.|:::..:..| .:.....||...||                |||    :.|||  .||
Mouse    57 EVVIPLRVTGNRPMWAMGWLTYSLHFGGQ----------------KHF----IHIKA--KKF--- 96

  Fly   130 LELNSQLLSPNIQQKHYHVGGYLVDGNRHDIE-----HCYYHGTVKDYPGASAAFHTC-NGVSGV 188
              |.|:|.|         |..|...|..|..:     .|||||.:...|.:..|..|| .|..|:
Mouse    97 --LVSRLFS---------VFTYTKQGALHKDQPYVQNDCYYHGHMDGDPESMVAITTCYGGFQGI 150

  Fly   189 IHIGNETFVIHPFYGGDLSK-HPHVIFEARTKANK----GCANSGNLDSWRLSRRTKHLSAGVAG 248
            :.|....:.|.|   .:||. ..|::.:..::..:    .||
Mouse   151 LQINGTVYEIKP---KNLSSTFEHLVHKMDSEETELYPMRCA----------------------- 189

  Fly   249 VVEEIL-QAGVGRNKRDVREATKY---------IETAIIVDKAMFDKRNGSTRAEVIHDAIQVAN 303
            :.|||. |..:.:|:......:.|         ::.|::||.......|.:| :.|:.:...:.|
Mouse   190 LTEEIAKQMKLQQNENPTLMQSHYEGWWTHRSFLDLALVVDCERVHYHNNNT-SHVLVEVFTIVN 253

  Fly   304 IADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDTT------- 360
            |.:..:.||:..:.::.:|.|.:...|  ..::|::.:..|.|:.:|:| |:|..|..
Mouse   254 IINNIYETLDVELVLLGVEMWNEKNHV--QGRNINEFLVEFCDWKARSLNFRIPNDIAHIFVNLD 316

  Fly   361 -QLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVYEPHLLAGTM-------AHMIGHNIGMGH 417
             |:..|..:.||         ||.| :....||.      ||.|.:       ||.||||:||.|
Mouse   317 FQIYLGVAYVGG---------VCLP-SYNCGVDC------LLGGNLFYFGHIIAHEIGHNLGMEH 365

  Fly   418 DDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRN- 481
            |.  ..|.| ..:.|:||.:..|..     |||.||...:.....|..  |:..:...|.:.|.
Mouse   366 DS--SSCTC-GRNVCLMAPADNGIS-----KFSNCSYSYFWTKYPTAK--CMHKEKKSIGILRGK 420

  Fly   482 -CGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNEC 545
             ||:.||::.|:||||:.:.||.|.||.. :|.||..|.||.|.||..|::.....:||..:|||
Mouse   421 LCGDGVVDDGEQCDCGSAKNCADDPCCKR-SCTLKDGAACAFGLCCKYCQIMEAGTVCRKRDNEC 484

  Fly   546 DLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYE 610
            ||||:|:|...:||:||:..:||||   :.|  |||::..|.....||:.|:|....:||..||.
Mouse   485 DLPEWCNGHSHKCPNDVYLLDGSPC---RDG--GYCYEKRCNNRDKQCKQIFGKEARSADHSCYR 544

  Fly   611 QFNSKGSINGHCG--RDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEF 673
            :.|::|...|:||  |||   |::|...::.||.:||::..|.|        :.|...::.....
Mouse   545 ELNTQGDRFGNCGMIRDA---YLRCHDPDILCGRVQCENVTRIP--------FLRDHSTVHWTHL 598

  Fly   674 E---CKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHG 735
            .   |..|....|. :.|:.|:|||||.||...:|:|:.|||  ..:..::|...:    ||..|
Mouse   599 NGVTCWGTDYHFGM-TIPDIGIVKDGTDCGPEHVCINKKCVS--KPIWTSQCSPTT----CSMKG 656

  Fly   736 VCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVI 800
            ||.|.:.|.|:.||....|     |.:.|.......|.|..:.:.|::         |..:::..
Mouse   657 VCNNLHHCHCNRGWDPPHC-----LKSGLGGSIDSGPPNYNEKKHKKS---------IGLVSLFW 707

  Fly   801 ILTVIVKCVFISFATLAVCYRRKTTTLKYDPPYSKKP 837
            ||......:||.|......|        .:.|.|::|
Mouse   708 ILFACFSILFILFLFFLRSY--------IELPMSEEP 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	33/113 (29%)
		Reprolysin	270..473	CDD:279729	57/227 (25%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	57/225 (25%)
		Disintegrin	488..562	CDD:278623	33/73 (45%)
		ACR	566..713	CDD:214743	50/151 (33%)
Adam39	NP_001020551.3	Pep_M12B_propep	69..173	CDD:279848	38/142 (27%)
		Reprolysin	222..409	CDD:279729	56/215 (26%)
		ZnMc_adamalysin_II_like	222..408	CDD:239797	56/214 (26%)
		Disintegrin	428..501	CDD:278623	33/73 (45%)
		ACR	504..640	CDD:214743	51/154 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836156
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850