DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and ADAM22

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_006716091.1	Gene:	ADAM22 / 53616	HGNCID:	201	Length:	1024	Species:	Homo sapiens

Alignment Length:	1057	Identity:	289/1057 - (27%)
Similarity:	456/1057 - (43%)	Gaps:	212/1057 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PVGEVERLLKEYRQNQELVRRIGGHYYQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGF 103
            |.|:...:..|.|:....|.|      |.|.|::|.:.......:|..:|.     .|...|.|
Human    79 PGGDASLMELEKRKENRFVER------QSIVPLRLIYRSGGEDESRHDALD-----TRVRGDLG- 131

  Fly   104 NRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVD--GNRHDIEHCYYH 166
              |....|..:.|..:.||...|.||:.||..|||....::|...||..|:  |.    |||||.
Human   132 --GPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG----EHCYYQ 190

  Fly   167 GTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSK--HPHVIFEARTKANKGCANSGN 229
            |.::..|.:..|..||:|:.|:.:.||.|::|.|.......:  |.|.::::|       ....:
Human   191 GHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR-------LFEFS 248

  Fly   230 LDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVR-------EATKYIETAIIVDKAMFDKRN 287
            ||......:..:::..     :.||:....|:||.:|       |.|||||..|:.|..||.|.
Human   249 LDDLPSEFQQVNITPS-----KFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKH- 307

  Fly   288 GSTRAEVIHD---AIQVANIADLYFR-TLNTRVSVVYIETWG-KNQAVIDGSKDISKAISNFNDY 347
               |..|:|.   |..|.|:|||.:: .|.||:.:|.:|||. .|:..|..:..|:  :..|..|
Human   308 ---RLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLIT--LREFMKY 367

  Fly   348 TSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVY-EPHLLAGTMAHMIGH 411
             .|:..:.:.|...|.:|..|....:|.|....:|:....|   .||.: :..|:|.|:|..:.|
Human   368 -RRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGG---GVNEFGKTDLMAVTLAQSLAH 428

  Fly   412 NIGMGHDDGR---EECFCRD-WHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNK 472
            |||:..|..:   .||.|.| |.||||..:    ....|.||::|:.::|.|.|.:|.|.||.||
Human   429 NIGIISDKRKLASGECKCEDTWSGCIMGDT----GYYLPKKFTQCNIEEYHDFLNSGGGACLFNK 489

  Fly   473 PNEIELRRNCGNKVVEEDEECDCGTFEECALD--QCCDGITCKLKSEAQCASGACCDQCRLRPKD 535
            |:::.....|||..:|..|||||||..||.|:  :||.  .|.|..::||:.|.||.:|:.:|..
Human   490 PSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQCSDGLCCKKCKFQPMG 552

  Fly   536 YICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYG 600
            .:||::.|:||:.|.|.|...||..::.|.:|..|    .|:.|.||.|.|.|...||:.|||..
Human   553 TVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSC----DGVQGICFGGRCKTRDRQCKYIWGQK 613

  Fly   601 GSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTI 665
            .:|:|:.|||:.|.:|:..|:||:| .:.:|:|...:|.||.|.|.:....|....:|...:.|:
Human   614 VTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTL 677

  Fly   666 ISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLE 730
            :..:|:...|  :.|.|......:.|.|:||||||..::||...|:.: ...:.:.|.::.:|..
Human   678 VVQQGRTLNC--SGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPV-ASFNFSTCLSSKEGTI 739

  Fly   731 CSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRIST 795
            ||.:|||:|..:|.|:..|.|:||::..             |.|    :..:|....|......|
Human   740 CSGNGVCSNELKCVCNRHWIGSDCNTYF-------------PHN----DDAKTGITLSGNGVAGT 787

  Fly   796 LTMVIILTVIVKCVFISFATLAVC------YRRKTTTLKYDPPYSKKPIAKSYGGAATAPNHHSV 854
               .||:.:|...:.:....|.:.      ||.:....:.|  |.|||
Human   788 ---NIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGD--YVKKP----------------- 830

  Fly   855 EEVSLDGSSKLVYANQTGFRDKGIHGRRYTTCGEDDQSHAE--KGI-------LKKHGYGLVH-- 908
                                            |:.|..:::  .|:       .||...||.|
Human   831 --------------------------------GDGDSFYSDIPPGVSTNSASSSKKRSNGLSHSW 863

  Fly   909 GEQLKDKWGDDNQSDNLELITQDGTLASTS-----GG-----------AAASEVERTLKSLNGYH 957
            .|::.|       :.::..|.::|...|.|     ||           ..::..||..::....|
Human   864 SERIPD-------TKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTEREPQAPEPGH 921

  Fly   958 EDILEALRNAATHRGTGTG--NTPVGSGSLSEEMLR----------KTLQDCNNSQLG------Y 1004
                 :|......:|...|  ::| .:|||....|.          |.::|.|.:..|      .
Human   922 -----SLAQTVPSQGISPGGSDSP-QTGSLDHRYLNPWFKRDYNVAKWVEDVNKNTEGPYFRTLS 980

  Fly  1005 SAEQYKRNIGSKSSSRE 1021
            .|:....:.||.:|||:
Human   981 PAKSPSSSTGSIASSRK 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	37/110 (34%)
		Reprolysin	270..473	CDD:279729	71/212 (33%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	70/210 (33%)
		Disintegrin	488..562	CDD:278623	32/75 (43%)
		ACR	566..713	CDD:214743	50/146 (34%)
ADAM22	XP_006716091.1	Pep_M12B_propep	127..239	CDD:279848	39/118 (33%)
		Reprolysin	291..490	CDD:279729	71/212 (33%)
		ZnMc_adamalysin_II_like	291..488	CDD:239797	70/210 (33%)
		Disintegrin	505..579	CDD:278623	32/75 (43%)
		ACR	582..723	CDD:214743	50/147 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9427
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0002073
OrthoInspector	1	1.000	-	-		otm41664
orthoMCL	1	0.900	-	-		OOG6_103986
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.810