Protein Alignment mmd and Adam4l1

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_001102747.1
• Gene: Adam4l1 / 500688
• RGDID: 1597022
• Length: 747
• Species: Rattus norvegicus
• Alignment Length: 734
• Identity: 201/734 - (27%)
• Similarity: 306/734 - (41%)
• Gaps: 126/734 - (17%)

  Fly    67 IIYPVQLRH-HEKMGISTREVSLP-KPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFR-- 127
            ::.||...| ..|...||.||.:| |..||....|.||          |.|      ::.:||
  Rat    27 LLSPVCCSHGPPKWRFSTSEVVIPRKVPQRMGKSDMSG----------HIT------YSMRFRGQ 75

  Fly   128 ---LDLELNSQLLSPNI----------QQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAF 179
               :.::|...::|.|.          ||:.|....          :.||::..::..||:.|..
  Rat    76 RHVVHMKLKKNMISQNFPVYTSNDQGAQQEDYPFVP----------QDCYFYSYLEGVPGSQATL 130

  Fly   180 HTC-NGVSGVIHIGNETFVIHPFYGGDLSKHPHVI----FEARTKANKGCANSGNLDSWRLSRRT 239
            .|| .|:.|:|.:.:.|:.|.|....  ||..|||    .:.|::.:|.|.|.
  Rat   131 DTCTGGLKGMIRVDDSTYEIKPLTSS--SKFEHVISLLVVDERSRKSKKCRND------------ 181

  Fly   240 KHLSAGVAGVVEEILQAGVGRNKRDVREATKYI------ETAI---IVDKAMFDKRNGSTRAEVI 295
            :.::.....:|:|...||      ..|.|..|:      ..||   :..:...|  .||...:.:
  Rat   182 EIMAEAGDSLVKETKLAG------SPRAAPVYLWRIHVKSIAIMYTVTHQVFLD--GGSNITQSL 238

  Fly   296 HDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTT 360
            ...:.:..|||..:|.....|.:..:..|........|..:|.:.:..:..:.:|..:::...|.
  Rat   239 ELTMTLNTIADSIYRPSGLIVFIRALCLWNDGDHFPTGDGNIWRLMERYGYWKARFFWEMHHATA 303

  Fly   361 QLL-----TGETFAGGEAGMAVPETVCTPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDG 420
            .||     :...:||.:.|      ||.|....:...|......|.|..:||.:||.:.:|||
  Rat   304 ALLISNIRSNAEYAGFQDG------VCNPNWGVLYTHVGKNHYFLAASFLAHAVGHILNVGHD-- 360

  Fly   421 REECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELR------ 479
            :..|.|.....|.|.:.....:     ..|.||.......:....| | |::| .:..|
  Rat   361 KPGCVCFRRSSCTMHEYPTLHD-----MMSNCSHNVLHYRIHDWDG-C-LSQP-RVSYRWINYAV 417

  Fly   480 RNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNE 544
            ..||||:|:..|:||||:|::||.|.|| |.||:|.:.:.||||.||..|:..|...:||.....
  Rat   418 PRCGNKIVDNGEKCDCGSFKDCASDHCC-GTTCELTASSVCASGGCCQSCKFAPIGTVCRQKGGI 481

  Fly   545 CDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCY 609
            |||||||.|:...||.:....:|:||  |...:   |..|.|....|||:|::|:....|...||
  Rat   482 CDLPEYCSGKSEHCPGNFHIMDGTPC--SPLAV---CVSGNCSDRQLQCQALFGFNVKDASPACY 541

  Fly   610 EQFNSKGSINGHCG-RD--ANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSR-TIISIKG 670
            ::.|:||...|:|| |:  .....::|:.|:|.||.:.| ||.:.....|....:.. .::.||
  Rat   542 KELNTKGDRFGNCGIREVRGGSKPMRCQEEDVLCGQIHC-DGVKFIPGGGEHTTFHHIKVMDIK- 604

  Fly   671 QEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHG 735
             |.:|.......|: ..||.|||.||..||....|..|.||  |.......|..:    :|:..|
  Rat   605 -EEQCFGYDAHHGA-QVPEMGLVVDGATCGPGKYCRGQRCV--FHQTMGFNCNVS----KCNYKG 661

  Fly   736 VCTNTNRCFCDMGWGGNDC 754
            ||.|...|.|..||...||
  Rat   662 VCNNQGNCHCVQGWQPPDC 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	28/129 (22%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	43/214 (20%)
		Disintegrin	488..561	CDD:459709	35/72 (49%)
		ACR	566..713	CDD:214743	49/150 (33%)
Adam4l1	NP_001102747.1	Pep_M12B_propep	46..163	CDD:460254	35/144 (24%)
		ZnMc_adamalysin_II_like	214..404	CDD:239797	42/206 (20%)
		Disintegrin	426..498	CDD:459709	35/72 (49%)
		ACR	502..643	CDD:214743	47/149 (32%)