DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and Adam4l1

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001102747.1	Gene:	Adam4l1 / 500688	RGDID:	1597022	Length:	747	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	201/734 - (27%)
Similarity:	306/734 - (41%)	Gaps:	126/734 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 IIYPVQLRH-HEKMGISTREVSLP-KPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFR-- 127
            ::.||...| ..|...||.||.:| |..||....|.||          |.|      ::.:||
  Rat    27 LLSPVCCSHGPPKWRFSTSEVVIPRKVPQRMGKSDMSG----------HIT------YSMRFRGQ 75

  Fly   128 ---LDLELNSQLLSPNI----------QQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAF 179
               :.::|...::|.|.          ||:.|....          :.||::..::..||:.|..
  Rat    76 RHVVHMKLKKNMISQNFPVYTSNDQGAQQEDYPFVP----------QDCYFYSYLEGVPGSQATL 130

  Fly   180 HTC-NGVSGVIHIGNETFVIHPFYGGDLSKHPHVI----FEARTKANKGCANSGNLDSWRLSRRT 239
            .|| .|:.|:|.:.:.|:.|.|....  ||..|||    .:.|::.:|.|.|.
  Rat   131 DTCTGGLKGMIRVDDSTYEIKPLTSS--SKFEHVISLLVVDERSRKSKKCRND------------ 181

  Fly   240 KHLSAGVAGVVEEILQAGVGRNKRDVREATKYI------ETAI---IVDKAMFDKRNGSTRAEVI 295
            :.::.....:|:|...||      ..|.|..|:      ..||   :..:...|  .||...:.:
  Rat   182 EIMAEAGDSLVKETKLAG------SPRAAPVYLWRIHVKSIAIMYTVTHQVFLD--GGSNITQSL 238

  Fly   296 HDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTT 360
            ...:.:..|||..:|.....|.:..:..|........|..:|.:.:..:..:.:|..:::...|.
  Rat   239 ELTMTLNTIADSIYRPSGLIVFIRALCLWNDGDHFPTGDGNIWRLMERYGYWKARFFWEMHHATA 303

  Fly   361 QLL-----TGETFAGGEAGMAVPETVCTPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDG 420
            .||     :...:||.:.|      ||.|....:...|......|.|..:||.:||.:.:|||
  Rat   304 ALLISNIRSNAEYAGFQDG------VCNPNWGVLYTHVGKNHYFLAASFLAHAVGHILNVGHD-- 360

  Fly   421 REECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELR------ 479
            :..|.|.....|.|.:.....:     ..|.||.......:....| | |::| .:..|
  Rat   361 KPGCVCFRRSSCTMHEYPTLHD-----MMSNCSHNVLHYRIHDWDG-C-LSQP-RVSYRWINYAV 417

  Fly   480 RNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNE 544
            ..||||:|:..|:||||:|::||.|.|| |.||:|.:.:.||||.||..|:..|...:||.....
  Rat   418 PRCGNKIVDNGEKCDCGSFKDCASDHCC-GTTCELTASSVCASGGCCQSCKFAPIGTVCRQKGGI 481

  Fly   545 CDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCY 609
            |||||||.|:...||.:....:|:||  |...:   |..|.|....|||:|::|:....|...||
  Rat   482 CDLPEYCSGKSEHCPGNFHIMDGTPC--SPLAV---CVSGNCSDRQLQCQALFGFNVKDASPACY 541

  Fly   610 EQFNSKGSINGHCG-RD--ANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSR-TIISIKG 670
            ::.|:||...|:|| |:  .....::|:.|:|.||.:.| ||.:.....|....:.. .::.||
  Rat   542 KELNTKGDRFGNCGIREVRGGSKPMRCQEEDVLCGQIHC-DGVKFIPGGGEHTTFHHIKVMDIK- 604

  Fly   671 QEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHG 735
             |.:|.......|: ..||.|||.||..||....|..|.||  |.......|..:    :|:..|
  Rat   605 -EEQCFGYDAHHGA-QVPEMGLVVDGATCGPGKYCRGQRCV--FHQTMGFNCNVS----KCNYKG 661

  Fly   736 VCTNTNRCFCDMGWGGNDC 754
            ||.|...|.|..||...||
  Rat   662 VCNNQGNCHCVQGWQPPDC 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	26/122 (21%)
		Reprolysin	270..473	CDD:279729	44/216 (20%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	43/214 (20%)
		Disintegrin	488..562	CDD:278623	35/73 (48%)
		ACR	566..713	CDD:214743	49/150 (33%)
Adam4l1	NP_001102747.1	Pep_M12B_propep	60..163	CDD:279848	29/130 (22%)
		ZnMc_adamalysin_II_like	214..404	CDD:239797	42/206 (20%)
		Reprolysin	214..403	CDD:279729	42/205 (20%)
		Disintegrin	426..499	CDD:278623	35/73 (48%)
		ACR	502..643	CDD:214743	47/149 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010