Protein Alignment mmd and Adam5

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_001423543.1
• Gene: Adam5 / 498654
• RGDID: 621471
• Length: 773
• Species: Rattus norvegicus
• Alignment Length: 832
• Identity: 215/832 - (25%)
• Similarity: 328/832 - (39%)
• Gaps: 197/832 - (23%)

  Fly   119 IKAFNH--KFRLDLELNSQLLSPNIQQKHYHVGGYLVDGN------------------------R 157
            ::|..|  |..|...:..::.||:::....:...||:..|                        |
  Rat    14 LQAGQHPQKTILQTTVPEKISSPDVETDPENHMAYLITINENPHFIHLKKQSFITSTAVSYTYDR 78

  Fly   158 HDIEH---------CYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKHPHVI 213
            .|:.|         |.|:|.|..:|.:..:...|:|:.|:|...|.::.|.|.  ..||...|||
  Rat    79 QDVRHSQSLSSLKNCNYNGYVAGFPNSIVSLTVCSGLRGMIQFENVSYGIEPV--ETLSGFIHVI 141

  Fly   214 FEARTK--------ANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATK 270
            :|...:        .|:..:.|..||   ...|:....:|.|     :|:             .:
  Rat   142 YENTNQQAKIPDLGENQTYSWSDELD---YQFRSNMKKSGFA-----VLR-------------PR 185

  Fly   271 YIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSK 335
            ||:|.|:|||.:||.....||. |:...||:....:..|..|...|.:..:|.|.|...:
  Rat   186 YIKTDIVVDKKLFDYMGSDTRV-VLQKVIQIIGFINTMFSKLKLTVLINSVEIWSKENRI----- 244

  Fly   336 DISKAISNF--------NDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTP---RAVGI 389
            |..:|..|.        :.|..:::        ..|..........|...|..:|.|   .|:.:
  Rat   245 DFPEAPENLLVQFLHWKHKYRPQHI--------SYLLAFVEHPASTGALYPGNLCKPIYGAAIAL 301

  Fly   390 ---SVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSE 451
               .:.:..|...:|     .::...||:.:|:. :.|.|.. ..|:|....:....|:  .||.
  Rat   302 YPKGLSLESYSVIVL-----QLLSIGIGLTYDNA-DSCHCTG-DVCLMTPKAIYSGGVK--DFST 357

  Fly   452 CSKKDYIDALRTGHGLCLLNKPNEIEL------RRNCGNKVVEEDEECDCGTFEECALDQCCDGI 510
            ||..|: ..|.|....||.:.|.|.:.      ||.|||.::|.:|:|||||.:.|...:|||.:
  Rat   358 CSLDDF-KYLSTQDLECLQDLPMERQKKKPSRPRRICGNGILEMNEQCDCGTLKNCTHKKCCDPM 421

  Fly   511 TCKLKSEAQCASGACCDQ-CRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSK 574
            :|:|||:|.|.||.||.| |:::|.:.:||.|.||||..|||:|....|..|.|.:||..|...:
  Rat   422 SCRLKSKAVCGSGECCGQDCKVKPVNVLCRKSKNECDFEEYCNGNDAYCVPDTFARNGQYCDSGQ 486

  Fly   575 TGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQ 639
                .:|:.|.|.|.:.||..:.|.....|...|||:|||:....|:|.|..      |..||..
  Rat   487 ----AFCYSGLCMTSNNQCMNLLGKYVRGASFACYEEFNSRNDRFGNCIRKF------CSFENSL 541

  Fly   640 CGTLQCK-DGERQPVNDGIDQLYSR----TIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPC 699
            ||.|.|. ..:|..:.|.:...|.:    ..||:.......|.|.......|..:...|||||.|
  Rat   542 CGKLVCTWPFKRLLMKDNMSAAYGQIRDDLCISLYKGGRPLKTTLSTYSDMSERDETFVKDGTIC 606

  Fly   700 GDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTAL 764
            |.::.||...|......||..:|   :...:|::||||.|.|.|.||.|:....|.||
  Rat   607 GPDMFCLETQCKETRFLVDFQQC---NTSRDCNDHGVCNNFNHCHCDKGYNPPYCESV------- 661

  Fly   765 PTEALPTPENTIKMEKKETPYGTSD---------------QNR----ISTLTMVIILT----VIV 806
                             :..:|:.|               |||    ...|.:::.:|    :|:
  Rat   662 -----------------KGQFGSIDDGHKYYIDEGKSAKQQNRGIHPKQQLQLILYITLPLIMII 709

  Fly   807 KCVFISFATLA-VCYRR----------------KTTT----LKYDPPYSKKP 837
            ..|||..:.|: :|.|.                |.||    ...|||.:..|
  Rat   710 SAVFIKQSKLSRLCGRERSEGTSCITEDSVSNTKMTTNEGRSSADPPITPNP 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	28/129 (22%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	49/214 (23%)
		Disintegrin	488..561	CDD:459709	36/73 (49%)
		ACR	566..713	CDD:214743	45/151 (30%)
Adam5	NP_001423543.1	Pep_M12B_propep	26..142	CDD:460254	24/117 (21%)
		Reprolysin	185..378	CDD:426256	49/216 (23%)
		Disintegrin	399..473	CDD:459709	36/73 (49%)
		ACR	477..620	CDD:214743	45/152 (30%)