DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Tace

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	692	Identity:	162/692 - (23%)
Similarity:	248/692 - (35%)	Gaps:	183/692 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLL 137
            |||:|   |..::..:.:..:|...|..:.||   |.|....|:|     ...|||       :|
  Fly    33 LRHYE---IFHKDDVVHRVVKRGAKHSTNPFN---TIKEVEFTTL-----GKNFRL-------IL 79

  Fly   138 SPNIQQKHYHVGGYLV--DGNR------HDIEHCYYHGTVKDYPGASAAFHTCNGVSGV-IHIGN 193
            .|:....|.....|.|  |||.      ||   .:|.|.|.....:|...|..:|...: ||:..
  Fly    80 HPHRDVLHSKFRAYAVDADGNETVVHMDHD---SFYSGRVFGELESSVRAHIEDGTMTMSIHLPE 141

  Fly   194 ETFVIHPFYG--GDLSKHPHVIFEAR-TKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQ 255
            ||:.|.|.:.  .:..|...|.::|. .|.:|..|.:               :....|.::|.|:
  Fly   142 ETYHIEPSWRHLPEAKKDTMVAYKASDVKVHKNEAGA---------------TPKTCGYIKEGLE 191

  Fly   256 AGVGRNK------------RDVREATKYIET--------AIIVDKAMFDKRNGSTRAEVIHDAIQ 300
            .   .:|            |:.|::.:|..|        .::.|...|.:..|......|:
  Fly   192 L---EDKEHGDTLDNELHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTIN---- 249

  Fly   301 VANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAI----------------SNFN---- 345
                   |..:|..||..:|.:|..::::..:|.|.:...|                :::|
  Fly   250 -------YLISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIRE 307

  Fly   346 DYTSRNLFQI------ERD--TTQLLTGETFAGGEAGMAVPET--------VCTPRAV------- 387
            .:..|||.::      .:|  ...|.|...|.||..|:|...:        :|||...
  Fly   308 KWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNGYTLY 372

  Fly   388 ---GISVDVNVYEPHLLAG----TMAHMIGHNIGMGHDDGREECFCRDWHG---CIMAQSIVGQE 442
               |:|...|.|...::..    ..||..|||.|..||....||......|   .:...|:.|.:
  Fly   373 LNSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDIPECSPSASQGGSFLMYTYSVSGYD 437

  Fly   443 NVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEECDCGTFEECALDQCC 507
             |...|||.||.:.....|:...|.| .::|.|    ..|||..||.||:||.|.......|.||
  Fly   438 -VNNKKFSPCSLRSIRKVLQAKSGRC-FSEPEE----SFCGNLRVEGDEQCDAGLLGTEDNDSCC 496

  Fly   508 DGITCKLKSE--AQCA--SGACCDQCRLRPKDYICRDSN-NECDLPEYCDGEIGQCPSDVFKKNG 567
            |. .|||:..  |.|:  :..||..|:.......||::. ..|:....|.|...:||......:|
  Fly   497 DK-NCKLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADG 560

  Fly   568 SPCGLSKTGISGYCFQG----YCPTLSLQ---CEAIWGYGGSAADRQCYEQFNSKGSINGHCGRD 625
            :.|     ...|.|..|    ||.|..||   |:.|     :.|.::|             |...
  Fly   561 TTC-----QERGQCRNGKCVPYCETQGLQSCMCDII-----ADACKRC-------------CRMS 602

  Fly   626 ANEHYIKCEPENV-----QCGTLQCKDGE-RQPVNDGIDQLY 661
            .||.....||.:|     .|.|..|..|. .:.:.|.:::.:
  Fly   603 INETCFPVEPPDVLPDGTPCITGFCNKGVCEKTIQDVVERFW 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	30/117 (26%)
		Reprolysin	270..473	CDD:279729	56/263 (21%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	56/261 (21%)
		Disintegrin	488..562	CDD:278623	25/78 (32%)
		ACR	566..713	CDD:214743	25/109 (23%)
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	34/129 (26%)
		ZnMc_TACE_like	223..470	CDD:239798	56/263 (21%)
		Reprolysin_2	244..456	CDD:290307	48/223 (22%)
		Disintegrin	477..552	CDD:278623	23/75 (31%)
		ADAM17_MPD	576..633	CDD:271205	19/74 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447377
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.880