DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam34l

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001020411.1	Gene:	Adam34l / 384813	MGIID:	3647273	Length:	736	Species:	Mus musculus

Alignment Length:	667	Identity:	190/667 - (28%)
Similarity:	292/667 - (43%)	Gaps:	117/667 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 LDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNG-VSGVIHI 191
            :.::....|:|.|.....|...|.|::.:......|||||.|.:.|.:....:||.| :.|.:.|
Mouse    74 ITMKPKENLISRNFLLFTYSDQGDLLEEHPFVQNDCYYHGYVDEDPESLVIVNTCFGSLQGTLEI 138

  Fly   192 GNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQA 256
            ....:.|.|  ....|...|:.::         .:||..:       ...:..|::  .|||.|.
Mouse   139 NGTIYEIMP--RSKTSTFEHLAYK---------MDSGESE-------PSPMRCGLS--EEEIAQQ 183

  Fly   257 GVGRNKRDVREAT-------------KYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLY 308
               .|.::...:|             ::|:..:::|...:..||.:| ...|.|.:||.|..:.|
Mouse   184 ---MNLQESNASTLLQIPYENWWTHHRFIDYFVVIDHNCYVHRNNNT-TTCIQDMLQVVNGINGY 244

  Fly   309 FRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLF--QIERDTTQLLTGETFAGG 371
            |..:.|.|.:..:|.|.:|. :|:..:::|.|:..|..: .:|..  ::..|...|.....:. .
Mouse   245 FLQIQTDVVLTKVEVWSQNN-LINVEEEMSAALDAFCSW-KKNAIGNRVRHDIIHLFVRHNYV-K 306

  Fly   372 EAGMAVPETVCTPRAVGISVDVNVY---EPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCI 433
            ..|||....||    :.::..||.:   ....||..:||.:|||:||.||.  ..|.| ..|.||
Mouse   307 FLGMAKLGQVC----LTLNCAVNSFLTDSLSYLAFIVAHEMGHNLGMKHDG--SACTC-GLHTCI 364

  Fly   434 MAQSIVGQENVQPY-----KFSECSKKDYIDALRTGHGLCLLNKPNEIE----LRRNCGNKVVEE 489
            |          .||     |||.||.::....:  ....||.|.|:.::    :...|||.:|||
Mouse   365 M----------YPYAYISPKFSNCSYEEMFSVV--NRRSCLYNIPDALKTITLVPTMCGNNLVEE 417

  Fly   490 DEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGE 554
            .|:||||..|.|..|.||.. .|.||..|:||.|.||..|:......:||...|||||||:|:|.
Mouse   418 GEQCDCGNSESCLQDPCCSS-DCVLKPGAKCAFGLCCKDCQFLQTGTVCRQEKNECDLPEWCNGT 481

  Fly   555 IGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSIN 619
            .|:||.||:|.:|..|..     .|||::..|.....||..|:|....:||..||.:.|.:|...
Mouse   482 SGECPGDVYKADGIRCSR-----GGYCYKMECQRHDRQCREIFGKRSRSADEICYMEMNRRGDRF 541

  Fly   620 GHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLY-----SRTIISIKGQEFECKATS 679
            |:||.|:: .|.:||..:|.||.:||::..:.|.....:.::     :.|..::   ::....|.
Mouse   542 GNCGNDSS-MYKRCELTDVLCGRIQCENVIKLPQRRNHETVHYTHFSNNTCWTM---DYHFGITI 602

  Fly   680 GQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVS-------LFPHVDQTKCPANSQGLECSEHGVC 737
            ..||:        |.|||||..:.|||::.|||       ..||:             |...|||
Mouse   603 DDVGA--------VSDGTPCAPDHICLDRKCVSKSVLVSNCTPHL-------------CHMQGVC 646

  Fly   738 TNTNRCFCDMGWGGNDC 754
            .|.:.|.|...|...||
Mouse   647 NNKHHCHCTNTWEPPDC 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	22/85 (26%)
		Reprolysin	270..473	CDD:279729	58/212 (27%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	57/210 (27%)
		Disintegrin	488..562	CDD:278623	36/73 (49%)
		ACR	566..713	CDD:214743	45/158 (28%)
Adam34l	NP_001020411.1	Pep_M12B_propep	41..159	CDD:366707	22/86 (26%)
		ZnMc_adamalysin_II_like	207..395	CDD:239797	57/210 (27%)
		Disintegrin	416..488	CDD:365943	36/72 (50%)
		ACR	492..628	CDD:214743	44/152 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836149
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850