DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam20

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001009548.1	Gene:	Adam20 / 384806	MGIID:	2152342	Length:	760	Species:	Mus musculus

Alignment Length:	762	Identity:	218/762 - (28%)
Similarity:	338/762 - (44%)	Gaps:	149/762 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 KKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIE-----HCYYHGT 168
            :|||    :.|||  .||     |.|:|.|         |..|...|..|..:     .|||||.
Mouse    85 QKHF----IHIKA--KKF-----LVSRLFS---------VFTYTKQGALHKDQPYVQNDCYYHGH 129

  Fly   169 VKDYPGASAAFHTC-NGVSGVIHIGNETFVIHPFYGGDLSK-HPHVIFEARTKANKGCANSGNLD 231
            :...|.:..|..|| .|..|::.|....:.|.|   .:||. ..|::.:              :|
Mouse   130 MDGDPESMVAITTCYGGFQGILQINGTVYEIKP---KNLSSTFEHLVHK--------------MD 177

  Fly   232 SWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVRE--------------ATKYIETAIIVDKAM 282
                |..|:.|....| :.|||.:    :.||...|              ...:::.|::||...
Mouse   178 ----SEETELLPMRCA-LTEEIAK----QMKRQQNENPTLMQNHYEEWWTHRSFLDLALVVDCER 233

  Fly   283 FDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAV-IDGSKDISKAISNFND 346
            ....|.:....::...:.::.|..:|| .|:..|.::.:|.|.:...| :|..:.:   :..|..
Mouse   234 IRYHNNNKSHVLVEVFLIISLINKIYF-ALDIEVVLIGLELWNEGNLVPVDRMQIL---LEEFCV 294

  Fly   347 YTSRNL-FQIERDTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVYEPHL--LAGTMAHM 408
            :.:.:| .:|..|...|....:| |...|:|...|||.| :....|| .:..|:|  .|..:||.
Mouse   295 WKTLSLNIRIPNDIAHLFVNHSF-GKFLGLAYVGTVCLP-SHNCGVD-RLLGPNLFQFAHIIAHE 356

  Fly   409 IGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKP 473
            ||||:||.||.  ..|.|...:.|:|:.:.    :..| :||.||..::.....|.:  ||..:.
Mouse   357 IGHNLGMEHDS--SSCTCGGINYCLMSSTY----SFNP-EFSNCSYSNFWTTYATTN--CLRKEK 412

  Fly   474 NEI-ELR-RNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDY 536
            ..| .|: :.|||.||::.|:||||....|..||||:. .|.|...|.||.|.||..|::.|...
Mouse   413 MSIGNLQIQFCGNGVVDDGEQCDCGDRHMCERDQCCNS-RCALNDGAACAFGLCCLYCQIMPAGT 476

  Fly   537 ICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGG 601
            :||:..|||||||:|:|...:||:||:..:||||   :.|  |||::..|.....||:.|:|...
Mouse   477 VCREEVNECDLPEWCNGHSHKCPNDVYLLDGSPC---RDG--GYCYEKRCNNRDEQCKQIFGKEA 536

  Fly   602 SAADRQCYEQFNSKGSINGHCG--RDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRT 664
            .:||..||.:.|::|...|:||  |||   |::|...::.||.:||::..|.|        :.|.
Mouse   537 RSADHSCYRELNTQGDRFGNCGMIRDA---YLRCHDSDILCGRVQCENVTRIP--------FLRD 590

  Fly   665 IISIKGQEFE---CKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANS 726
            ..::......   |..|....|. :.|:.|:|||||.||...:|:|:.|||....::|  |.:.:
Mouse   591 HSTVHWTHLNGVTCWGTDYHFGM-TIPDIGIVKDGTDCGPEHVCINKKCVSKPIWLEQ--CSSKT 652

  Fly   727 QGLECSEHGVCTNTNRCFCDMGWGGNDC------SSVVLLTTALPTEALPTPENTIKMEKKETPY 785
                |:..|||.|.:.|.|:.||....|      .||         ::.|.|
Mouse   653 ----CTMKGVCNNLHHCHCNRGWDPPHCLESGFGGSV---------DSGPPP------------- 691

  Fly   786 GTSDQNRISTLTMVIILTVIVKCVFISFATLAVCYRRKTTTLKYDPP 832
            |..:..:...|.::..:..||..||: ...|...|.|  |:.|::.|
Mouse   692 GEEESQQHMDLVLITPILSIVSLVFL-LPWLLNRYIR--TSSKFEEP 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	33/110 (30%)
		Reprolysin	270..473	CDD:279729	53/206 (26%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	53/204 (26%)
		Disintegrin	488..562	CDD:278623	33/73 (45%)
		ACR	566..713	CDD:214743	50/151 (33%)
Adam20	NP_001009548.1	Pep_M12B_propep	57..173	CDD:366707	33/110 (30%)
		ZnMc_adamalysin_II_like	222..408	CDD:239797	51/201 (25%)
		Disintegrin	429..501	CDD:365943	33/72 (46%)
		ACR	505..641	CDD:214743	50/152 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836155
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850