DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and Adam26b

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001009547.1	Gene:	Adam26b / 382007	MGIID:	3588304	Length:	699	Species:	Mus musculus

Alignment Length:	660	Identity:	203/660 - (30%)
Similarity:	296/660 - (44%)	Gaps:	106/660 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 LDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNG-VSGVIHI 191
            :.::....|:|.|:....|...|.|::........|||||.|.:.|.:....:||.| :.|.:.|
Mouse    62 ITMKPKKNLMSRNLILLTYTQQGDLLEQRPFVPNDCYYHGYVDEDPESLVILNTCFGSLQGTLEI 126

  Fly   192 GNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQA 256
            ...|:.|.|  ....|...|:.:    |.:.|       ||     ....:..|::  .|||.|
Mouse   127 NGTTYEIMP--KSSTSTFEHLAY----KMDNG-------DS-----EPSPMRCGLS--EEEIAQ- 170

  Fly   257 GVGRNKRDVREAT----------------KYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIA 305
                 :|.:||..                ::||..:::|...:..||.:. ...|.|.:|:.|..
Mouse   171 -----QRKLRERNAPTLLQIPHENWWTHHRFIEYFVVIDHKQYVHRNNNI-TTCIQDMLQIVNGV 229

  Fly   306 DLYFRTLNTRVSVVYIETWG-KNQAVIDGSKDISKAISNFNDYTSRNLF--QIERDTTQLLTGET 367
            :.|:..::|.|.:..:|.|. ||...::.|  |.|.:.:|..: .:|:|  :|..|...||..:.
Mouse   230 NGYYLQIDTDVVLTALEIWNEKNYINVELS--IFKVLGDFCTW-KQNMFGNRIRHDIIHLLVRQG 291

  Fly   368 FAGGEAGMAVPETVCTPRAVGIS---VDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDW 429
            : |...|:|....||||...|:|   .||.....|:    :||.:|||:||.||.....|..:|
Mouse   292 Y-GLYLGLAYLADVCTPYNCGVSSFLSDVMSDMAHI----VAHEMGHNLGMKHDGIGCTCGLKD- 350

  Fly   430 HGCIMAQSIVGQENVQPY-----KFSECSKKDYIDALRTGHGLCLLNKPNEIELRRN-CGNKVVE 488
              |:||          ||     |||.||.::....:....  ||.:.|..:..... |||||||
Mouse   351 --CLMA----------PYKTNSPKFSNCSYEEMYSVVTKRS--CLYDIPEALVTNLTVCGNKVVE 401

  Fly   489 EDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDG 553
            |.||||||:.|.|..|.||.. .|.||..||||.|.||..|:......:||:..|||||||:|:|
Mouse   402 EGEECDCGSTESCLQDPCCSS-DCVLKPGAQCAFGLCCQDCQFLKTGTVCREEKNECDLPEWCNG 465

  Fly   554 EIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSI 618
            ...:||.||:|.:|.||    :| .|||::..|.....||..|:|.|..:||..||.:.|.:|..
Mouse   466 TSAECPGDVYKADGIPC----SG-EGYCYKMECHQRDEQCRKIFGNGSRSADEICYMEMNRRGDR 525

  Fly   619 NGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSR----TIISIKGQEFECKATS 679
            .|:||.|::::.| ||..:|.||.:||         :.:.||..|    |:.........|....
Mouse   526 FGNCGNDSSKYKI-CELADVLCGRIQC---------ENVIQLPQRRNHETVHYTHFSNVTCWTMD 580

  Fly   680 GQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCF 744
            ...|. :..:.|.|.|||.|....||:::.|||      ::...:|.....|...|||.|.|.|.
Mouse   581 YHFGI-TIDDIGAVSDGTACAPYHICVDRKCVS------KSDLVSNCTTKLCHMQGVCNNKNHCH 638

  Fly   745 CDMGWGGNDC 754
            |...|...||
Mouse   639 CTNTWEPPDC 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	23/85 (27%)
		Reprolysin	270..473	CDD:279729	61/213 (29%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	61/211 (29%)
		Disintegrin	488..562	CDD:278623	37/73 (51%)
		ACR	566..713	CDD:214743	47/150 (31%)
Adam26b	NP_001009547.1	Pep_M12B_propep	39..144	CDD:279848	22/83 (27%)
		Reprolysin	195..385	CDD:279729	61/213 (29%)
		ZnMc_adamalysin_II_like	195..383	CDD:239797	61/211 (29%)
		Disintegrin	401..474	CDD:278623	37/73 (51%)
		ACR	477..613	CDD:214743	48/157 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850