Protein Alignment mmd and sona

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_001137746.1
• Gene: sona / 37762
• FlyBaseID: FBgn0034903
• Length: 1102
• Species: Drosophila melanogaster
• Alignment Length: 1442
• Identity: 261/1442 - (18%)
• Similarity: 423/1442 - (29%)
• Gaps: 545/1442 - (37%)

  Fly    64 YYQIIYPVQLRHHEKMGISTREVSL---PKPGQRPRPHDDSGFNRGRTKKHFH---RTSLLIKAF 122
            :|::   |||:|||. ..:.|..|:   ||......||.   ..:..:|..::   :...|....
  Fly    48 HYEL---VQLQHHEN-NHNRRRRSIGKGPKVNAALPPHH---VKKDLSKNAYYSELKHEALASGG 105

  Fly   123 NHKFRLDLELNSQLLSPNIQ----QKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAF---- 179
            ||.|..::   |.:.|.|:.    .:|.::......|......|.....||...|.|:...
  Fly   106 NHLFAPEV---SAIKSHNVSFSAFGQHLNLSLRATQGLFKGAPHQLRMWTVGSEPNATHGLDLQE 167

  Fly   180 -----HTCNGVSGVIH------------------------IGNETFVIHPFYGGDLSKHP----H 211
                 ||.|.|..|..                        ||:: .||.|. ..:||.:|    |
  Fly   168 IVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIMEGSIGHD-LVIKPL-PHELSPNPEESHH 230

  Fly   212 VIFEARTKANKGCAN------------SGNLDSWRLSRRTKH-------------LSAGVAGVVE 251
            :|::....|.:|..:            |..|:  ||.||.:.             |:....|.::
  Fly   231 IIYKREASAAEGQLSDFAFMEPDDLLASEKLE--RLQRRQRRSRRSAPSSPDFEDLNDEDEGALD 293

  Fly   252 EILQAGVGRNKRDVREATK--YIETAIIVDKAMFD--KRNGSTRAEVIHDAIQVANIADLYFRTL 312
            ...|....|. |..|:|..  |.|..:|||   :|  :.:|....:|....|...|..||.:|.|
  Fly   294 GEPQVAESRT-RSRRQAPYIIYPEVLVIVD---YDGYRLHGGDNLQVKRYFISFWNGVDLRYRLL 354

  Fly   313 ---NTRVSVV------------YIETWGKNQAVIDGSKDISKAISNFNDYTSRN----LFQIERD 358
               ..|:|:.            |:|   :|:...| :.|.:.|:::...|..|.    ::.|...
  Fly   355 KGPRIRISIAGIIISRGRDATPYLE---RNRVGRD-AIDSAAALTDMGKYLFRERRLPVYDIAVA 415

  Fly   359 TTQL-LTGETFAGGE-----AGMAVPETVCT-------PRAVGISVDVNVYEPHLLAGTMAHMIG 410
            .|:| :...|.|.||     ||.|.....|.       ..:|.|..|...:...::|   ||.:|
  Fly   416 ITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVA---AHEVG 477

  Fly   411 HNIGMGHD----------DGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGH 465
            |.:|..||          .|.:.|...|  |.||:..   :...:.:::|.|:.:.:...|....
  Fly   478 HLLGAVHDGSPPPSYLGGPGAQRCRWED--GYIMSDL---RHTERGFRWSACTVQSFHHFLNGDT 537

  Fly   466 GLCLLNKPNE-IELRRNCGNKVVEEDEEC--DCGTFEECALDQCCDGITCKLKSEAQCASGACCD 527
            ..||.|.|:| ..|.|:....::..|.:|  |.||:            .| .|.|..||...|
  Fly   538 ATCLHNAPHEDSALGRSLPGTLLSLDAQCRRDRGTY------------AC-FKDERVCAQLFC-- 587

  Fly   528 QCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGY-CFQGYCPTLSL 591
                                   .|.:.|.|.:......||.||      :|| |..|.|  ..|
  Fly   588 -----------------------FDAQTGYCVAYRPAAEGSACG------NGYHCLDGRC--TPL 621

  Fly   592 QCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDG 656
            ....|..||.:.  |..|.:.::|        :||.|.......|.      :.::.|.:.|.|
  Fly   622 PSNIIPDYGHNY--RLVYNKIDNK--------KDAAEDVESSSEET------ESQEDETESVED- 669

  Fly   657 IDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTK 721
                                                                             
  Fly   670 ----------------------------------------------------------------- 669

  Fly   722 CPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYG 786
               ..:|...||.                                      :...|:|:.....|
  Fly   670 ---QDEGTTSSEE--------------------------------------QEDNKIEQSSAAGG 693

  Fly   787 TSDQNRISTLTMVIILTVIVKCVFISFATLAVCYRRKTTTLKYDPPYSKKPIAKSYGGAATAPNH 851
            .:.|   ||.|.....|..|:..             .|||.      :.||.:||:|..     |
  Fly   694 AAAQ---STTTARSTTTTTVRTT-------------STTTT------TAKPKSKSFGYL-----H 731

  Fly   852 HSVEEVSLDGSSKLVYANQTGFRDKGIHGRRYTTCGEDDQSHAEKGILKKHGYGLVHGEQLKDKW 916
            .|:.|                                                         .:|
  Fly   732 RSLPE---------------------------------------------------------RQW 739

  Fly   917 GDDNQSDNLELITQ--DGTLASTSGGAAASEVERTLKSLNGYHEDILEALRNAATHRGTGTGNTP 979
                ..||..|:|.  ..:::|:|.|:::.|...|                  :|.|.|.|..|.
  Fly   740 ----MQDNGVLVTTRISSSVSSSSSGSSSGEAAAT------------------STRRPTTTTTTQ 782

  Fly   980 VGS-GSLSEEMLRKTLQ------DCNNSQLGYSAEQYKRNIGSKSSSRENICDNAAVHAIILDGS 1037
            ..: ..:....|||.::      ........:..||.::    :|..:::|.:...|...:
  Fly   783 TPNLFQIYTHELRKQIEYYLHMLQTQQHATKFQPEQQQQ----QSQQQQSIVEIPLVQKSL---- 839

  Fly  1038 GGGLGGMGLGSSVGAGGGSTSMSGGMPGHGGTMLHHHRSQHQLHQPSTVALQPQQLDDDDAPSTG 1102
                      ::......|:|.|.|......:....::.|.|..|.:...||....|:::..:.|
  Fly   840 ----------TNYSVTSSSSSTSNGAKQQPPSNKDENQRQQQQQQQAQQQLQDGLPDEENEATAG 894

  Fly  1103 PLRIRNLEDLIRQLEHHSSRHMSPSGSEDIRMSETEADRHYRLESSAACSESSQGSNQQIPQSQK 1167
               |::.|.:.||                        .|.:....:||.|.:.:.:....|.:..
  Fly   895 ---IQSNEAIERQ------------------------KRKFPTTPTAATSAAQKSATPATPATSA 932

  Fly  1168 TATIHASYSRSCRPRSDEESRFT---FGGRYRQPASSGRHAPHQSHSPHAFGHHTHHSHAHGHAT 1229
            |         |.||........|   |...|.:..    .|.|.:.|..:....|..:......:
  Fly   933 T---------SARPTPTTAKPITTSSFLDAYFKKL----QALHDAGSASSSTTTTTTTSVSSSVS 984

  Fly  1230 HGPHSSHHSSHTHLQQEDEGIYETADHHERQVVDARLDCHETPDSESDDFIQAQQQLARWASEDV 1294
            ....|.........||:.:.|.:.:...:|....:.|..::|..|.|::
  Fly   985 SATSSKQQHPQQQQQQQVQQIADGSHFLKRTPHRSSLKAYKTSSSSSNN---------------- 1033

  Fly  1295 VSVVVLDQPPSGTMSDSQPYIDVGPISGAIAQQQHPHQQQQQQQQQQHPHQHHGDHHQSSAAAAG 1359
                          |.||.                  ||||||||||:...:.||...:..|...
  Fly  1034 --------------SSSQT------------------QQQQQQQQQQYATNYIGDTTNNQPAVLD 1066

  Fly  1360 SGSGVAAATSVA 1371
            :....::.|..|
  Fly  1067 NSGSASSTTETA 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	29/153 (19%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	57/246 (23%)
		Disintegrin	488..561	CDD:459709	14/74 (19%)
		ACR	566..713	CDD:214743	23/147 (16%)
sona	NP_001137746.1	ZnMc_salivary_gland_MPs	313..542	CDD:239800	56/243 (23%)
		ADAMTS_CR_2	556..619	CDD:465496	23/108 (21%)