Protein Alignment mmd and adam8a

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_956931.1
• Gene: adam8a / 368917
• ZFINID: ZDB-GENE-030616-622
• Length: 843
• Species: Danio rerio
• Alignment Length: 741
• Identity: 213/741 - (28%)
• Similarity: 330/741 - (44%)
• Gaps: 150/741 - (20%)

  Fly   105 RGRTKKHFHRTSLLIKAFNHKFRLD-----------LELNSQLLSPNIQQKHYHVGGYLVDGNRH 158
            ||||:    |::..::.:..:...|           |..|.:||.......||...|.....:.:
Zfish    38 RGRTR----RSASSLQKYPEQLEYDVAIDGRNLTISLHRNRELLGKQYTLTHYGEDGISETKSSN 98

  Fly   159 DIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPF---YGGDLSKHPHVIFEARTKA 220
            ...||||||.:.::..:|.:...|:|:.|.:.:.::.::|.|.   ..||     |.|::..
Zfish    99 KFNHCYYHGHIHNFEDSSVSVGLCSGMEGFLRVNDQVYLIEPLEESLDGD-----HAIYKQE--- 155

  Fly   221 NKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEIL------QAGV--GRNKRD--VREATKYIETA 275
                           ..|||.   |..|.:.:.:      .:|:  |:|.|:  .|...:.:|..
Zfish   156 ---------------HLRTKR---GAYGYINDTVYDLGPKSSGLYKGKNMRNKAPRGGQQIVEMV 202

  Fly   276 IIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKA 340
            ::||...: |:.||.: ::....:.|||..|..:|.||.||.:|.:|.|.:.. :||.|...:..
Zfish   203 LVVDNTEY-KKFGSFK-KIEERMMLVANHVDKLYRPLNIRVMLVGLEVWSQRD-LIDVSSRPNLT 264

  Fly   341 ISNFNDYTSRNLFQIER-DTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVYEPHLLAGT 404
            :..|..:...:|.|.:: |....:||..|.|...|:|....:|:..:.|...:.:...|..:|.|
Zfish   265 LERFLKWRRDSLLQRKKHDNAHFITGIDFEGSTVGLATLYAMCSSSSSGAVNEDHNSNPIAVAST 329

  Fly   405 MAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSK---KDYIDALRTGHG 466
            :||.:|||:||.|||  ..|.|....||||..:|   .::.|..||.||:   |.:::...|.
Zfish   330 VAHEMGHNLGMSHDD--SSCGCSSNKGCIMGDTI---GSIYPDSFSTCSQSSLKAFLENYDTN-- 387

  Fly   467 LCLLNKPNEIELRRN--CGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQC 529
             ||::.|||.::...  |||..||:.|||||||.|||. :.||:..||:|...|:||.|.||..|
Zfish   388 -CLIDVPNEGQIYGGPVCGNAFVEKGEECDCGTVEECN-NPCCNATTCRLTEGARCAHGECCHNC 450

  Fly   530 RLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCE 594
            :|:....:||.|.::|||.|||.||...||.|.:|.||.||..::    |||:.|.|||....|:
Zfish   451 QLKHTGSLCRKSAHDCDLDEYCTGESAFCPEDDYKMNGLPCNYNQ----GYCYNGQCPTHKEHCK 511

  Fly   595 AIWGYGGSAADRQCYEQFN-----SKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQP-- 652
            .:||.|....|..|: |:|     ||.:                  |:.:||.:.|..|...|
Zfish   512 MLWGSGADVDDDACF-QYNVIDRTSKSA------------------EHRKCGRIYCYGGNPFPKT 557

  Fly   653 -----VNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVS 712
                 ||     :.|||          |...   :.|:...:.|:|..||.||.|.:|....|:.
Zfish   558 NKKANVN-----VQSRT----------CYMA---LDSSPTEDLGMVPTGTKCGTNKVCYKSLCLD 604

  Fly   713 LFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDC------------SSVVLLTTALP 765
            :..:  .|:..:|    :|:..|||.:..:|.||.||....|            |.|:.:||:|.
Zfish   605 ISMY--GTENCSN----KCNNRGVCNHELKCHCDPGWAPPYCDIQLSELHKMRKSVVIGVTTSLA 663

  Fly   766 -------TEALPTPENTIKMEKKETP 784
                   ..||....|.|...:|:.|
Zfish   664 ILVLIIIIGALVYNRNKITEFRKKRP 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	28/122 (23%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	62/204 (30%)
		Disintegrin	488..561	CDD:459709	37/72 (51%)
		ACR	566..713	CDD:214743	43/158 (27%)
adam8a	NP_956931.1	Pep_M12B_propep	32..157	CDD:460254	29/145 (20%)
		ZnMc_adamalysin_II_like	199..389	CDD:239797	60/200 (30%)
		DISIN	410..484	CDD:214490	38/74 (51%)
		ACR	486..605	CDD:214743	43/159 (27%)
		EGF_2	617..640	CDD:400365	9/22 (41%)
		PHA03378	<685..783	CDD:223065	2/5 (40%)