Protein Alignment mmd and Adam34l

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_001419773.1
• Gene: Adam34l / 364599
• RGDID: 1307052
• Length: 792
• Species: Rattus norvegicus
• Alignment Length: 792
• Identity: 216/792 - (27%)
• Similarity: 336/792 - (42%)
• Gaps: 135/792 - (17%)

  Fly    82 STREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHY 146
            |..|..:|......|.|..:|:           .|..::....|..:.::....|:|.|.....|
  Rat    26 SPPEAVIPLRVTDTRKHTSTGW-----------LSYSLQFGGEKCIITMKPKKNLISRNFLLFTY 79

  Fly   147 HVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNG-VSGVIHIGNETFVIHPFYGGDLSKHP 210
            ...|.|::........||||..|.:.|.:....:.|.| :.|::.|.:.|:.|.|  ....|...
  Rat    80 SEQGDLLEEQPFVQNDCYYHDYVDEDPESFVIVNNCFGSLQGILEINDTTYEIMP--KSSTSTFD 142

  Fly   211 HVIFEARTKANKGCANSGNLD----SWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDV-REAT- 269
            |:.:.         .|||..:    .|.||.             |||.:    :.||.| .::|
  Rat   143 HLAYR---------MNSGASELFPMRWGLSE-------------EEIAR----QMKRRVSNDSTP 181

  Fly   270 ------------KYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIE 322
                        |:||..:|:|...:..|:.:|.| .|.|.:|:.|....|:..::|.|.:..:|
  Rat   182 MKIPYESWWTHHKFIEYFVIIDNNQYVHRSSNTTA-CIQDMLQMINGISGYYLQIDTDVVLKTLE 245

  Fly   323 TWG-KNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDTTQLLTGETFAGGEAGMAVPETVCTPR 385
            .|. ||...::  ::|...:::|..:...:: .::..|...|.....: |....:|...|||||.
  Rat   246 VWNEKNHVNVE--QNIHNVLNDFCTWKQTSIGNRVRHDIIHLFVRHRY-GIYLALAHVGTVCTPN 307

  Fly   386 AVGISVDVNVYEPHL--LAGTMAHMIGHNIGMGHD-DGREECFCRDWHGCIMAQSIVGQENVQPY 447
            ...::   ::....:  :|..:||.:|||:||.|| .|   |.| ....||||          ||
  Rat   308 NCSVN---SIISDSMSDMAFIIAHEMGHNLGMLHDVSG---CTC-GRKSCIMA----------PY 355

  Fly   448 -----KFSECSKKD-YIDALRTGHGLCLLNKPNEIELRRN--CGNKVVEEDEECDCGTFEECALD 504
                 |||.||.:: |....|..:   |.|.|:.:.....  |||.:|||.|:||||..|.|:.|
  Rat   356 KSNSAKFSNCSYEEMYSVVTRRSY---LYNTPDTLVTTHMTVCGNNLVEEGEQCDCGNLESCSKD 417

  Fly   505 QCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSP 569
            .|... .|.||..||||.|.||...:..|...:||...||.||||:|:|...:||.||:..:|||
  Rat   418 PCYSE-DCVLKPGAQCAFGLCCQDFQFLPTGTMCRKEKNESDLPEWCNGSSHECPGDVYLLDGSP 481

  Fly   570 CGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCE 634
            |    :| .|||::........||:.|:|....:|:..||.:.|.:|....:|| :.:|:||.|.
  Rat   482 C----SG-GGYCYKMAWHEREAQCKKIFGMESRSANEICYMEMNKQGDRFDNCG-NHSENYIGCN 540

  Fly   635 PENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPC 699
            ..:|.||.:||.:.|:.|:....:.|:....     ..|.|.......||.: .:...|:|||.|
  Rat   541 ITDVFCGRIQCDNVEQIPLRKNHETLHWTQF-----NNFTCWTMDYHFGSTT-EDSRAVEDGTAC 599

  Fly   700 GDNLICLNQTCVS---LFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLT 761
            |.|.||:::.|||   ||         .|.....||..|||.|.:.|.|::.|...||.......
  Rat   600 GPNHICIDRKCVSKSILF---------GNCSESFCSMQGVCNNKDHCHCNVPWEPPDCQLPGFRD 655

  Fly   762 TALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLAVCY--RRKT 824
            :.....:|.|..|     ::||..|.|        .:..|:..::...|:....|.:.:  :||.
  Rat   656 SIDSGPSLGTLTN-----QRETVKGKS--------LVGFIIPFMISLFFLILLILQLAFYQKRKA 707

  Fly   825 TTLKYDPPYSKK 836
            ..:....|..|:
  Rat   708 EKIPEHTPKRKR 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	23/110 (21%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	57/211 (27%)
		Disintegrin	488..561	CDD:459709	34/72 (47%)
		ACR	566..713	CDD:214743	47/149 (32%)
Adam34l	NP_001419773.1	Pep_M12B_propep	29..146	CDD:460254	28/129 (22%)
		ZnMc_adamalysin_II_like	194..377	CDD:239797	55/203 (27%)
		Disintegrin	401..473	CDD:459709	34/72 (47%)
		ACR	477..613	CDD:214743	46/147 (31%)