Protein Alignment mmd and Adam32

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_700446.2
• Gene: Adam32 / 353188
• MGIID: 2653822
• Length: 754
• Species: Mus musculus
• Alignment Length: 885
• Identity: 216/885 - (24%)
• Similarity: 366/885 - (41%)
• Gaps: 170/885 - (19%)

  Fly     8 LILIIAQLCVFVTSAGEADYTLDDSFWNEESPVGEVERLLKEYRQNQELVRRIGGHYYQIIYPVQ 72
            |:|::|:|...:.|..|:.                                   ..:.:||:|.:
Mouse    10 LLLLLAELGALLASGPESQ-----------------------------------SSFLEIIFPEK 39

  Fly    73 LRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLL 137
            :   |....|..::|...|..:.:      :.....|::|.....::..:|       :.::...
Mouse    40 I---EDKTHSEEQISYIIPINKKQ------YTVHLQKRYFLTNRFMVYMYN-------QGSTSFH 88

  Fly   138 SPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFY 202
            ||||..:                  |||.|.:|.||.:.|...||:|:.|.:...|.::.|.|..
Mouse    89 SPNIPAQ------------------CYYQGHIKGYPNSVATLSTCSGLRGFLQFENVSYGIEPLQ 135

  Fly   203 GGDLSKHPHVIFEARTKA-----NKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNK 262
            ....|:  |::::...|.     ||   ||.|                    :|.....|:..||
Mouse   136 SAFTSQ--HIVYKLGNKEKELIFNK---NSRN--------------------IEMPTNYGILINK 175

  Fly   263 RDVREATK-----YIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIE 322
            :. :...|     |:|.:|:||||::|.. ||....|.:..|::.::.:..|..|...:.:..:|
Mouse   176 KP-KSPFKNLFPLYLEMSIVVDKALYDYL-GSDSNIVTNKIIEIISLINSVFAQLKVTIVLSSLE 238

  Fly   323 TWG-KNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTPRA 386
            .|. ||:....|..|  :.:..|.::....|.....|...|.....:. ...|...|..:||..
Mouse   239 LWSDKNKIPTVGEAD--ELLHKFLEWKQAYLTLRPHDVAYLFIYNEYP-NYMGATYPGKMCTAH- 299

  Fly   387 VGISVDVNVYEPHL----LAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPY 447
              .|..:.:|...:    .:..:..|:|.::|:.:|: .|:|:|.: ..|||....:....|:
Mouse   300 --YSAGITMYPKDMTLEAFSVILTQMLGLSLGISYDE-PEKCYCSE-SICIMNPRAMQYGGVK-- 358

  Fly   448 KFSECSKKDYIDALRTGHGL-CLLNKPNEIELRRN----CGNKVVEEDEECDCGTFEECALDQCC 507
            .||.||..|: :..::..|. ||.|||   :::|.    |||..||.||.||||:..||..|.||
Mouse   359 SFSNCSLNDF-EHFKSNEGAKCLQNKP---QMQRTAAAVCGNGKVEGDEICDCGSEAECGPDSCC 419

  Fly   508 DGITCKLKSEAQC----ASGACCDQCRLRPKDYICR-DSNNECDLPEYCDGEIGQCPSDVFKKNG 567
            :...|.||:...|    .|..||..|:..|:.:.|| :.:..||:||.|:|..|.||.||...||
Mouse   420 EPNRCVLKAGRACDSKSPSSTCCKNCQFLPEKHQCRPEKHLYCDIPEVCNGSSGNCPPDVTINNG 484

  Fly   568 SPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIK 632
            ..|..|.|    .|:.|.||.|...||:|:|.|...|...|||:...:....|:||:|....|:.
Mouse   485 HVCKESGT----ICYNGDCPDLDRVCESIYGAGSVNAPFACYEEIQGQNDRFGNCGKDNRNRYVF 545

  Fly   633 CEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGT 697
            |...|:.||.|.|....|.|.|...:.  :.::|....::..|  .:...||:...:...|.:|.
Mouse   546 CGWRNLICGRLICTYPTRMPYNPPNNS--TASVIYAFVRDKVC--ITVDFGSSVKEDPLRVANGA 606

  Fly   698 PCGDNLICLNQTCVSLFPHVDQTK-CPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLT 761
            .|..:.||||..||......||:| |.:     :|..:|||.:...|.|:.|:...:|.    ..
Mouse   607 TCDLDRICLNGVCVESRFLRDQSKTCSS-----KCHGNGVCNSHGVCHCNAGYSPPNCQ----YP 662

  Fly   762 TALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFI---SFATLAVCYRRK 823
            |...:.:|.:.::.:.||:     .:.:|.:...|::.|:| :|:..||:   .:..|..|..::
Mouse   663 TTKRSASLWSGKHDLPMER-----ASKNQEKKWLLSLYIVL-IILASVFLIGTGWKGLKQCGSKE 721

  Fly   824 TTTLKYDPPYSKKPIAKSYGGAATAPNHHSVEEVSLDGSS 863
            ..::..:        :||.....|..:..:.|..|:..:|
Mouse   722 EESMSSE--------SKSEDSTYTYVSRSTSETSSMTSTS 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	24/109 (22%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	50/211 (24%)
		Disintegrin	488..561	CDD:459709	32/77 (42%)
		ACR	566..713	CDD:214743	46/146 (32%)
Adam32	NP_700446.2	Pep_M12B_propep	33..145	CDD:460254	31/147 (21%)
		Reprolysin	188..384	CDD:426256	50/207 (24%)
		Disintegrin	400..478	CDD:459709	32/77 (42%)
		ACR	483..622	CDD:214743	46/146 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	720..754		6/42 (14%)