DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam32

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_700446.2	Gene:	Adam32 / 353188	MGIID:	2653822	Length:	754	Species:	Mus musculus

Alignment Length:	885	Identity:	216/885 - (24%)
Similarity:	366/885 - (41%)	Gaps:	170/885 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LILIIAQLCVFVTSAGEADYTLDDSFWNEESPVGEVERLLKEYRQNQELVRRIGGHYYQIIYPVQ 72
            |:|::|:|...:.|..|:.                                   ..:.:||:|.:
Mouse    10 LLLLLAELGALLASGPESQ-----------------------------------SSFLEIIFPEK 39

  Fly    73 LRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLL 137
            :   |....|..::|...|..:.:      :.....|::|.....::..:|       :.::...
Mouse    40 I---EDKTHSEEQISYIIPINKKQ------YTVHLQKRYFLTNRFMVYMYN-------QGSTSFH 88

  Fly   138 SPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFY 202
            ||||..:                  |||.|.:|.||.:.|...||:|:.|.:...|.::.|.|..
Mouse    89 SPNIPAQ------------------CYYQGHIKGYPNSVATLSTCSGLRGFLQFENVSYGIEPLQ 135

  Fly   203 GGDLSKHPHVIFEARTKA-----NKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNK 262
            ....|:  |::::...|.     ||   ||.|                    :|.....|:..||
Mouse   136 SAFTSQ--HIVYKLGNKEKELIFNK---NSRN--------------------IEMPTNYGILINK 175

  Fly   263 RDVREATK-----YIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIE 322
            :. :...|     |:|.:|:||||::|.. ||....|.:..|::.::.:..|..|...:.:..:|
Mouse   176 KP-KSPFKNLFPLYLEMSIVVDKALYDYL-GSDSNIVTNKIIEIISLINSVFAQLKVTIVLSSLE 238

  Fly   323 TWG-KNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTPRA 386
            .|. ||:....|..|  :.:..|.::....|.....|...|.....:. ...|...|..:||..
Mouse   239 LWSDKNKIPTVGEAD--ELLHKFLEWKQAYLTLRPHDVAYLFIYNEYP-NYMGATYPGKMCTAH- 299

  Fly   387 VGISVDVNVYEPHL----LAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPY 447
              .|..:.:|...:    .:..:..|:|.::|:.:|: .|:|:|.: ..|||....:....|:
Mouse   300 --YSAGITMYPKDMTLEAFSVILTQMLGLSLGISYDE-PEKCYCSE-SICIMNPRAMQYGGVK-- 358

  Fly   448 KFSECSKKDYIDALRTGHGL-CLLNKPNEIELRRN----CGNKVVEEDEECDCGTFEECALDQCC 507
            .||.||..|: :..::..|. ||.|||   :::|.    |||..||.||.||||:..||..|.||
Mouse   359 SFSNCSLNDF-EHFKSNEGAKCLQNKP---QMQRTAAAVCGNGKVEGDEICDCGSEAECGPDSCC 419

  Fly   508 DGITCKLKSEAQC----ASGACCDQCRLRPKDYICR-DSNNECDLPEYCDGEIGQCPSDVFKKNG 567
            :...|.||:...|    .|..||..|:..|:.:.|| :.:..||:||.|:|..|.||.||...||
Mouse   420 EPNRCVLKAGRACDSKSPSSTCCKNCQFLPEKHQCRPEKHLYCDIPEVCNGSSGNCPPDVTINNG 484

  Fly   568 SPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIK 632
            ..|..|.|    .|:.|.||.|...||:|:|.|...|...|||:...:....|:||:|....|:.
Mouse   485 HVCKESGT----ICYNGDCPDLDRVCESIYGAGSVNAPFACYEEIQGQNDRFGNCGKDNRNRYVF 545

  Fly   633 CEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGT 697
            |...|:.||.|.|....|.|.|...:.  :.::|....::..|  .:...||:...:...|.:|.
Mouse   546 CGWRNLICGRLICTYPTRMPYNPPNNS--TASVIYAFVRDKVC--ITVDFGSSVKEDPLRVANGA 606

  Fly   698 PCGDNLICLNQTCVSLFPHVDQTK-CPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLT 761
            .|..:.||||..||......||:| |.:     :|..:|||.:...|.|:.|:...:|.    ..
Mouse   607 TCDLDRICLNGVCVESRFLRDQSKTCSS-----KCHGNGVCNSHGVCHCNAGYSPPNCQ----YP 662

  Fly   762 TALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFI---SFATLAVCYRRK 823
            |...:.:|.:.::.:.||:     .:.:|.:...|::.|:| :|:..||:   .:..|..|..::
Mouse   663 TTKRSASLWSGKHDLPMER-----ASKNQEKKWLLSLYIVL-IILASVFLIGTGWKGLKQCGSKE 721

  Fly   824 TTTLKYDPPYSKKPIAKSYGGAATAPNHHSVEEVSLDGSS 863
            ..::..:        :||.....|..:..:.|..|:..:|
Mouse   722 EESMSSE--------SKSEDSTYTYVSRSTSETSSMTSTS 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	24/106 (23%)
		Reprolysin	270..473	CDD:279729	51/213 (24%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	50/211 (24%)
		Disintegrin	488..562	CDD:278623	32/78 (41%)
		ACR	566..713	CDD:214743	46/146 (32%)
Adam32	NP_700446.2	Pep_M12B_propep	40..144	CDD:279848	28/139 (20%)
		Reprolysin	188..384	CDD:279729	50/207 (24%)
		ZnMc_adamalysin_II_like	188..382	CDD:239797	49/205 (24%)
		Disintegrin	400..479	CDD:278623	32/78 (41%)
		ACR	483..622	CDD:214743	46/146 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..754		6/42 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920