Protein Alignment mmd and kuz

DIOPT Version :9

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Alignment Length: 1116
• Identity: 233/1116 - (20%)
• Similarity: 363/1116 - (32%)
• Gaps: 357/1116 - (31%)

  Fly   199 HP---FYGGDLS-KHPHVIFEARTKANKGC----------ANSGNLDSW------RLSRRTKHLS 243
            ||   :..||.. |:||..:.......:|.          .:|.|:..|      |:.|.|.: .
  Fly   328 HPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDN-G 391

  Fly   244 AGVAGVVEEILQAGVGRNKRDVRE-ATKYIETAIIV-----------DKAMFDKRNGSTRAEVIH 296
            ||..|     ...|.||.:.|.:. .:.||:|..::           |:....:.:..||.|:..
  Fly   392 AGDRG-----SSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITS 451

  Fly   297 -DAIQVANIADLYFRT--------LNTRVSVVYIET----------WGKNQAVIDGSKDISKAIS 342
             .|..|..:..:|..|        .|.|..|..|:.          .|.:.|..:...|    :|
  Fly   452 LIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMD----VS 512

  Fly   343 NFNDYTSRNLFQIERDT----TQLLTGETFAGGEAGMA------------------VPETV---- 381
            ||     .||..:|..:    ..:.|...|.||..|:|                  ..|||
  Fly   513 NF-----LNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQY 572

  Fly   382 -CTPRAV--GISVDVNV---YEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDW---HGCIMAQS 437
             .|.|::  ||...||.   ..|.:...|:||.||||.|..||..:|   ||..   ...||..|
  Fly   573 QSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQE---CRPGGLNGNYIMFAS 634

  Fly   438 IVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRN---------CGNKVVEEDEEC 493
            ....:.....|||.||.::..:.|....|          ..:|:         ||||:||..|||
  Fly   635 ATSGDRPNNSKFSPCSIRNISNVLDVLVG----------NTKRDCFKASEGAFCGNKIVESGEEC 689

  Fly   494 DCGTFEECALDQCC----------------DGITCKLKSEAQCASGACC--DQCRLRPKDY--IC 538
            |||..||...|:||                .|.|.:.|::...:.|.||  :.|...|..|  .|
  Fly   690 DCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKC 754

  Fly   539 RDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYC---PTLSLQCEAIWGYG 600
            :: ..||.....|:|...:||....:.:.:.|...    :..|.:|.|   |.|      :|..
  Fly   755 KE-ETECSWSSTCNGTTAECPEPRHRDDKTMCNNG----TALCIRGECSGSPCL------LWNM- 807

  Fly   601 GSAADRQCYEQFNSKGSINGHCGRDANEHYIK---CEPENVQCGTLQCKDGERQPVNDGIDQLYS 662
                 .:|:....:.            .|..|   |:        |.|:||     ||
  Fly   808 -----TKCFLTSTTL------------PHVSKRKLCD--------LACQDG-----ND------- 835

  Fly   663 RTIISIKGQEFECKATSGQVGSNSYPEHGL-VKDGTPCGDNLICLNQTCVSLFPHVDQTKCPA-N 725
                     ...|::||......:..:.|: ::.|:|| ||.    |....:|     .||.| :
  Fly   836 ---------TSTCRSTSEFADKYNIQKGGISLQPGSPC-DNF----QGYCDVF-----LKCRAVD 881

  Fly   726 SQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQ 790
            :.|.......:..|.........|..::...|||:..|
  Fly   882 ADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVA--------------------------- 919

  Fly   791 NRISTLTMVIILTVIVKCVFISFATLAVCYRRKTTTLKYDPPYSKKPIAKSYGGAATAPNHHSVE 855
                   .::::...:||..:.             |...:|   ||..|:.......||.:
  Fly   920 -------FIVVMGSFIKCCAVH-------------TPSSNP---KKRRARRISETLRAPMN---- 957

  Fly   856 EVSLDGSSKLVYANQTGFRDKGI----HGRRYTTCGEDDQSHAEKGILKKHGYGLVHGEQLKDKW 916
              :|....:  :.||.|...:.|    |..::.:.|.|.:.....| ..:||....|.:|....|
  Fly   958 --TLRRMQR--HPNQRGAGPRSIPPPAHEAQHYSRGGDGRGGGGGG-GGRHGGSRSHHQQHPHDW 1017

  Fly   917 GDDNQSDNLELITQDGTLASTSGGAAASEVERTLKSLNGYHEDILEALRNAATHRGTGTGNTPV- 980
            .......::..:...|  :.:|..:||::..|:                :....|.|.:|....
  Fly  1018 DRHQGGHSIVPLPTGG--SHSSRNSAANQARRS----------------DGRGPRSTSSGRPQAI 1064

  Fly   981 --GSGSLSEEMLRKTLQDCNNSQLGYSAEQYKRNIGSKSSSRENICDNAAVHAIILDGSGGGLGG 1043
              |||:.|         ....|..||.|||                        .:.||.||
  Fly  1065 ASGSGAAS---------GAARSHGGYGAEQ------------------------AIPGSIGG--- 1093

  Fly  1044 MGLGSSVGAGG--GSTSMSGGMPGHGGTMLHHHRSQHQLHQPSTVALQPQQLDDDDAPSTGPLRI 1106
             |:.:::.:||  ....:...:|...|......:.|.||.||   |:.|||.......:...|..
  Fly  1094 -GVQAAISSGGVVARAQLPLPLPPPNGQQQMQQQQQLQLQQP---AISPQQQPQQAFYTPKELPP 1154

  Fly  1107 RNLEDLIRQLEHHSSRHMSPSGSEDIRMSETEADRHYRL----ESSAACSESSQGSNQQIPQSQK 1167
            ||        :..|||..:.|.:.....|.|.|.....:    ..:.:.|:|..|.:.:...|:.
  Fly  1155 RN--------KSRSSRTNNTSNTTTTTNSSTAAAGSGSVSGPGSGAGSSSKSKSGKSAKAKDSKS 1211

  Fly  1168 TATIHASYSRS 1178
            ..:..|:.|||
  Fly  1212 QKSQQANNSRS 1222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	7/17 (41%)
		Reprolysin	270..473	CDD:279729	63/267 (24%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	63/265 (24%)
		Disintegrin	488..562	CDD:278623	28/93 (30%)
		ACR	566..713	CDD:214743	27/153 (18%)
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	64/288 (22%)
		Reprolysin_2	450..659	CDD:290307	54/220 (25%)
		Disintegrin	684..776	CDD:278623	28/92 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447375
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.850