DRSC/TRiP Functional Genomics Resources

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Protein Alignment mmd and adam17a

DIOPT Version :9

Sequence 1:NP_001285311.1 Gene:mmd / 32561 FlyBaseID:FBgn0259110 Length:1484 Species:Drosophila melanogaster
Sequence 2:XP_005158775.1 Gene:adam17a / 324142 ZFINID:ZDB-GENE-030131-2862 Length:848 Species:Danio rerio


Alignment Length:679 Identity:150/679 - (22%)
Similarity:221/679 - (32%) Gaps:204/679 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 YYQIIYPVQLRHHEKMGISTREVS---------------------LPKPG-----QRPRPHDDSG 102
            :|.::......|.....:|..|||                     ||..|     .|.|..|   
Zfish     6 FYLVLLAPLFAHCAVKPVSVEEVSRNEEELQEFDALNSLLSDFEVLPASGLQLHSVRKRDAD--- 67

  Fly   103 FNRGRTKKHFHRTSLL-IKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGN----RHDIE- 161
                   .|.|...|: ..|....|:|.|..|:||.:.|.       ....||.|    :.|:: 
Zfish    68 -------AHSHVERLVSFTALQRNFKLYLTTNTQLFTENF-------SAVFVDENGKEDQFDVQI 118

  Fly   162 HCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFE----------- 215
            ..|:.|.|                     :|.|...:.....|| ....|:|.|           
Zfish   119 QNYFKGHV---------------------VGEEHSRVQAHIDGD-EFSAHIITEETEYNVEPLWR 161

  Fly   216 ---------------------ARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVG 259
                                 :|..:.|.|... |.|:..|...    .|..|..:||:.:....
Zfish   162 FTETPPDGRLLVYRSEDIKNISRLSSPKVCGYV-NADAQELLPE----EARAAEEMEEMKEEPHN 221

  Fly   260 RNKRDVREATKYIETAIIVDKAMFDKRNGSTRAE---VIHDAIQ-VANIADLY--------FRTL 312
            |.:|...:..|...|.::|....|.|..|  |||   .::..|: :..:.|:|        |:..
Zfish   222 RERRSTHDQKKNTCTLLLVADHRFYKHMG--RAEESTTLNYLIELIDRVDDIYRNTSWDDDFKGY 284

  Fly   313 NTRVSVVYIE------TWGKNQAVIDGSK--------DISKAISNFNDYTSRNLFQIERDTTQ-- 361
            ..::..:.|.      ..|:....:|||.        |:.|.:..|:       :.|..:.::  
Zfish   285 GVQIQQIIINKDPTKVAPGEFHYNMDGSPTGRKDGVWDVKKLLEQFS-------YDIAANASRAC 342

  Fly   362 ---LLTGETFAGGEAGMAVPETVCTPRAVGI------------SVDVNVYEPHLLAGTM------ 405
               |.|.:.|..|..|:|    ...|...|:            ||....|....|..||      
Zfish   343 LAHLFTYQDFDDGTLGLA----YVAPSKPGLGGLCPKPYYPSQSVKKPSYLNTGLTSTMNYGKTI 403

  Fly   406 ---------AHMIGHNIGMGHD-DGREECFCRDWHG--CIMAQSIVGQENVQPYKFSECSKKDYI 458
                     .|.:|||.|..|| |....|...|..|  .:|....|..::|....||.|||....
Zfish   404 LTKEADLVTTHELGHNFGAEHDPDNIASCAPSDDQGGKYVMYPIAVSGDHVNNKHFSTCSKISVS 468

  Fly   459 DALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCA-- 521
            ..||.....|.:.:.:::     |||..|||||:||.|.. ....|.||.. .||.:.:|||:  
Zfish   469 KTLRIKVNQCFVERSSKL-----CGNSRVEEDEDCDPGLL-HINDDPCCTS-NCKFRKQAQCSDR 526

  Fly   522 SGACCDQCRLRPKDYICRD-SNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGY 585
            :..||..|.....|.:|:: ....|.....|.|...:||:....::.:.| :.|    |.|..|.
Zfish   527 NSPCCKNCMFESADKVCQEVITATCKGTSQCTGNSSECPTPGNLEDNTEC-VDK----GRCQNGQ 586

  Fly   586 CPTLSLQCEAIWGYGGSAADRQCYEQFNS 614
            |...   |||:......|    |.|..||
Zfish   587 CRPF---CEAVHNLESCA----CNETENS 608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mmdNP_001285311.1 Pep_M12B_propep 106..213 CDD:279848 23/112 (21%)
Reprolysin 270..473 CDD:279729 58/263 (22%)
ZnMc_adamalysin_II_like 270..471 CDD:239797 58/261 (22%)
Disintegrin 488..562 CDD:278623 25/76 (33%)
ACR 566..713 CDD:214743 14/49 (29%)
adam17aXP_005158775.1 Pep_M12B_propep 62..161 CDD:279848 28/137 (20%)
ZnMc_TACE_like 233..486 CDD:239798 57/265 (22%)
Reprolysin_2 257..471 CDD:290307 46/224 (21%)
Disintegrin 493..567 CDD:278623 25/75 (33%)
ADAM17_MPD 590..648 CDD:293303 8/26 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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