DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam19

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001153700.1	Gene:	Adam19 / 303068	RGDID:	1585017	Length:	920	Species:	Rattus norvegicus

Alignment Length:	856	Identity:	237/856 - (27%)
Similarity:	368/856 - (42%)	Gaps:	177/856 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IAQLCVFV--------TSAGEADYTLDDSFWNEESPVGEVERLLKEYRQNQELVRRIGGHYYQII 68
            :|:.|:..        .:|.|.::|...|  .|:||..:.|.::.::|.::.
  Rat     7 VARFCLLALALQLQWPLAACEPEWTTRGS--KEDSPPLQHELIIPQWRTSES------------- 56

  Fly    69 YPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELN 133
                                |:.|                 ||.....|.:.|...:..||||.|
  Rat    57 --------------------PRGG-----------------KHPLTAELRVMAEGRELILDLEKN 84

  Fly   134 SQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHI-GNETFV 197
            ..|.:|...:..|...|..........:||:|||||:....:|....||.|:.|:|.: .|.:::
  Rat    85 EHLFAPAYTETCYTASGNPQTTTLKSEDHCFYHGTVRKVDESSVTLSTCRGIRGLIIVRSNLSYI 149

  Fly   198 IHPFYGGDLSKHPHVIFEAR----TKANKGCANS-GNLDSWRL--SRRTKHLSAGVAGVVEEILQ 255
            |.|....|   :.|.|:.:.    ...|.|..:| .....|.|  :.:||....
  Rat   150 IEPVPNSD---NQHRIYRSEHLKLPPGNCGFEHSRPTSKDWTLQFTHQTKKQPR----------- 200

  Fly   256 AGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVY 320
                |.||:...:.||:|..::.|.|.|.| |...:....|..:::||..|.::|:|:.|:::|.
  Rat   201 ----RMKREDLHSMKYVELYLVADYAEFQK-NRHDQDATKHKLMEIANYVDKFYRSLSIRIALVG 260

  Fly   321 IETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTP- 384
            :|.|..... .:.|::....:.:|..:..:.|.|...|..||:||.:|.|...|:|....:|:.
  Rat   261 LEVWTHGDK-CEVSENPYSTLWSFLSWRRKLLTQKSHDNAQLITGRSFQGTTIGLAPLMAMCSVY 324

  Fly   385 RAVGISVDVNVYEPHL-----LAGTMAHMIGHNIGMGHD----------DGREECFCRDWHGCIM 434
            ::.|:|:|      |.     :|.|:||.||||.||.||          ||          ||||
  Rat   325 QSGGVSMD------HSENAIGVASTVAHEIGHNFGMSHDSAHCCSTSAADG----------GCIM 373

  Fly   435 AQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIEL--RRNCGNKVVEEDEECDCGT 497
            |   ....:..|..||.|::|:....|::|.|:||.|.|:...|  .|.|||..:|:.||||||.
  Rat   374 A---AATGHPFPKVFSSCNRKELDRYLQSGGGMCLSNMPDTRTLYGGRRCGNGYLEDGEECDCGE 435

  Fly   498 FEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDV 562
            .:||. :.||:...|.||..|:||.|:||.||:|......||:...:|||||:|.|:...||::.
  Rat   436 EDECK-NPCCNASNCTLKEGAECAHGSCCHQCKLVAPGTQCREQVRQCDLPEFCTGKSPHCPTNY 499

  Fly   563 FKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDAN 627
            ::.:|:||    .|...||:.|.|.|...||:.:||.|...|...|:|:.|:.|...|:||:..|
  Rat   500 YQMDGTPC----EGGQAYCYNGMCLTYQEQCQQLWGPGARPALDLCFERVNAAGDTYGNCGKGLN 560

  Fly   628 EHYIKCEPENVQCGTLQCKDGERQPVND---GIDQLYSRTIISIKGQEFECKAT------SGQVG 683
            ..|.||.|.:.:||.:||:..:.:|:..   .||     |.|::.|:...|:.|      ..:.|
  Rat   561 GKYRKCSPRDAKCGKIQCQSTQARPLESNAVSID-----TTITLNGRRIHCRGTHVYRGPEEEEG 620

  Fly   684 SNSYPEHGLVKDGTPCGDNLICLNQTC--VSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCD 746
            .....:.|||..||.||.|.||....|  .|.|   :...|     |.:|:.||||.|...|.|.
  Rat   621 EGDMLDPGLVMTGTKCGHNHICFEGQCRNTSFF---ETEGC-----GKKCNGHGVCNNNKNCHCF 677

  Fly   747 MGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFI 811
            .||....|:               ||.:...::....|..::........:.:.:|.|:|
  Rat   678 PGWAPPFCN---------------TPGDGGSIDSGPLPPKSAGPVIAGVFSALFVLAVLV----- 722

  Fly   812 SFATLAVCYRR 822
               .|..|||:
  Rat   723 ---LLCHCYRQ 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	31/107 (29%)
		Reprolysin	270..473	CDD:279729	66/218 (30%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	65/216 (30%)
		Disintegrin	488..562	CDD:278623	34/73 (47%)
		ACR	566..713	CDD:214743	51/157 (32%)
Adam19	NP_001153700.1	Pep_M12B_propep	62..162	CDD:279848	30/102 (29%)
		Reprolysin	211..409	CDD:279729	66/218 (30%)
		ZnMc_adamalysin_II_like	211..407	CDD:239797	65/216 (30%)
		DISIN	440..500	CDD:214490	25/60 (42%)
		ACR	502..650	CDD:214743	51/156 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7582
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920