DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and Adam10

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_062127.1	Gene:	Adam10 / 29650	RGDID:	2032	Length:	749	Species:	Rattus norvegicus

Alignment Length:	704	Identity:	163/704 - (23%)
Similarity:	246/704 - (34%)	Gaps:	204/704 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 IGGHYYQIIYPVQ--LRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLL-IKA 121
            :||.|..   |:.  :||:|  |:|....||.:..||.:          |...|..:..|| ..|
  Rat    17 LGGQYGN---PLNKYIRHYE--GLSYNVDSLHQKHQRAK----------RAVSHEDQFLLLDFHA 66

  Fly   122 FNHKFRLDLELNSQLLSPNIQQK------HYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFH 180
            ...:|.|.::.::.|.|...:.:      .|.. .::..|:.:..|..:.||:|.|
  Rat    67 HGRQFNLRMKRDTSLFSDEFKVETSNKVLDYDT-SHIYTGHIYGEEGSFSHGSVVD--------- 121

  Fly   181 TCNGVSGVIHIGNETFVIHP---------------FYGGDLSKHPHVIFEARTKANKGCANSGNL 230
              ....|.|.....||.|.|               .|..|...:||     :.....|||:....
  Rat   122 --GRFEGFIQTRGGTFYIEPAERYIKDRILPFHSVIYHEDDINYPH-----KYGPQGGCADHSVF 179

  Fly   231 DSWRLSRRT-------KHLSAGVAGVVEEILQAGVGRNKR----DVREATKYIETAIIVDKAMFD 284
            :..|..:.|       .|.....|.:..|:|     |.||    :......||:|     ..:|.
  Rat   180 ERMRKYQMTGVEEGTRAHSEEHAASMGPELL-----RKKRTTLAERNTCQLYIQT-----DHLFF 234

  Fly   285 KRNGSTRAEVIHDAIQVANIADLY-------FRTLNTRVSVVYIETWGKNQAVIDGSKD------ 336
            |..|:..|.:...:..|..|..:|       .|.::..|..:.|.|       ....||
  Rat   235 KYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINT-------TSDEKDPTNPFR 292

  Fly   337 -----ISKAI-----SNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTPRAV---- 387
                 :.|.:     .|.:||....:| .:||....:.|..:.|..:|.:  ..:|....:
  Rat   293 FPNIGVEKFLELNSEQNHDDYCLAYVF-TDRDFDDGVLGLAWVGAPSGSS--GGICEKSKLYSDG 354

  Fly   388 -------GISVDVNVYEPHLLAG----TMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQS-IVG 440
                   || :.|..|..|:...    |.||.:|||.|..||.|.|         |...:| .:|
  Rat   355 KKKSLNTGI-ITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTE---------CTPGESKNLG 409

  Fly   441 QENVQPY---------------KFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEED 490
            |:....|               |||.||.::....|......|.:.....|     |||.:||:.
  Rat   410 QKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPI-----CGNGMVEQG 469

  Fly   491 EECDCGTFEECALDQCC------DGITCKLKSEAQC--ASGACCD-QCRLRPKDYICRDSNNECD 546
            ||||||..::|. |:||      :|..||||...||  :.|.||. ||..:.|...||| :::|.
  Rat   470 EECDCGYSDQCK-DECCFDANQPEGKKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRD-DSDCA 532

  Fly   547 LPEYCDGEIGQCPSDVFKKNGSPCGL-SKTGISGYCFQGYCPTLSL-QCEAIWGYG--------- 600
            ....|:|....||:...|.|.:.|.. ::..|:|.|....|....| :|......|
  Rat   533 KEGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYDLEECTCASSDGKDDKELCHV 597

  Fly   601 -----------GSAADRQCYEQFNSK------GS----INGHCGRDANEHYIKC 633
                       .|....|..:|||.:      ||    ..|:|     :.:::|
  Rat   598 CCMKKMAPSTCASTGSLQWNKQFNGRTITLQPGSPCNDFRGYC-----DVFMRC 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	26/128 (20%)
		Reprolysin	270..473	CDD:279729	55/256 (21%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	55/254 (22%)
		Disintegrin	488..562	CDD:278623	32/82 (39%)
		ACR	566..713	CDD:214743	19/100 (19%)
Adam10	NP_062127.1	Pep_M12B_propep	48..141	CDD:307618	23/114 (20%)
		Cysteine switch	171..178		3/6 (50%)
		ZnMc_TACE_like	221..460	CDD:239798	55/263 (21%)
		DISIN	467..546	CDD:214490	31/80 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	705..749
		SH3-binding. /evidence=ECO:0000255	709..716
		SH3-binding. /evidence=ECO:0000255	723..729
		Interaction with AP2A1, AP2A2 and AP2M1. /evidence=ECO:0000250\|UniProtKB:O35598	735..749
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339806
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850