DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and Adam9

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001014772.2	Gene:	Adam9 / 290834	RGDID:	621473	Length:	845	Species:	Rattus norvegicus

Alignment Length:	851	Identity:	265/851 - (31%)
Similarity:	372/851 - (43%)	Gaps:	126/851 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLD 129
            |:|:.|.:|....      ||...|...|                     .|.:|:|...:..:.
  Rat    43 YEIVTPWRLSRER------REALRPSSKQ---------------------ISYVIQAQGKQHIIH 80

  Fly   130 LELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNE 194
            ||.|:.||..:.....|...|.|:..:.:...||:|.|.|:..|.::.|...|.|:.|::|:.|.
  Rat    81 LERNTDLLPNDFVVYTYDEEGSLLSDHPNVQSHCHYRGYVEGVPNSTVAVSACFGLRGLLHLENA 145

  Fly   195 TFVIHPFYGGDLSKHPHVIFEA----RTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQ 255
            :|.|.|.:..  |...||.:..    :.....|.:|.............:|.|      |.::|
  Rat   146 SFGIEPLHNS--SHFEHVFYPMDDVHQEPLRCGVSNRDTEQEATQGEEEEHPS------VTQLL- 201

  Fly   256 AGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVY 320
                |.:|.|...|:|:|..|:|||..::.. |..:..|..:.|::||..|..:..||.|:.:|.
  Rat   202 ----RRRRAVLPQTRYVELFIVVDKERYNMM-GRNQTAVREEMIRLANYLDSMYIMLNIRIVLVG 261

  Fly   321 IETWGKNQA--VIDGSKDISKAISNFNDYTSRNLFQIER---DTTQLLTGETFAGGEAGMAVPET 380
            :|.|.....  :|.|:.|:   :.||..:  |..|.|.|   |:.||:..:.| ||.||||...|
  Rat   262 LEIWTDRNPINIIGGAGDV---LGNFVQW--REKFLITRRRHDSAQLVLKKGF-GGTAGMAFVGT 320

  Fly   381 VCTPRAVGISVDVNVY---EPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQE 442
            ||:....|   .:||:   .....|..:||.:|||:||.||||| ||||.. ..|||.....|..
  Rat   321 VCSRSHAG---GINVFGQITVETFASIVAHELGHNLGMNHDDGR-ECFCAA-KSCIMNSGASGSR 380

  Fly   443 NVQPYKFSECSKKDYIDALRTGHGLCLLN--KPNEIELRRNCGNKVVEEDEECDCGTFEECALDQ 505
            |     ||.||.:|:........|.||||  ||:|.....:||||:|:..|||||||.:||.||.
  Rat   381 N-----FSSCSAEDFEKLTLNKGGSCLLNIPKPDEAYSAPSCGNKLVDPGEECDCGTPKECELDP 440

  Fly   506 CCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPC 570
            ||:|.||||||.|:||.|.||..|:..|...:||...:|||:||||:|....||.|||.:||.||
  Rat   441 CCEGSTCKLKSFAECAYGDCCKDCQFLPGGSMCRGKTSECDVPEYCNGSSQFCPPDVFIQNGYPC 505

  Fly   571 GLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEP 635
            ..||    .||:.|.|.....||:.|:|....||.|.|:.:.||||...|:|| .:..:|..|..
  Rat   506 WNSK----AYCYNGVCQYYDAQCQVIFGSKAKAAPRDCFIEVNSKGDRFGNCG-VSGSNYKTCAT 565

  Fly   636 ENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCG 700
            .|..||.|||::.:..||...:.     .||....:..:|.....|:||: .|:.|:|.:||.|.
  Rat   566 GNALCGKLQCENVQEMPVFGIVP-----AIIQTPSRGTKCWGVDFQLGSD-VPDPGMVNEGTKCD 624

  Fly   701 DNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALP 765
            ...||.|..||:  ..|....|  :.|| :|..||||.:...|.|:.||....|.
  Rat   625 AGKICRNFQCVN--ASVLNYDC--DIQG-KCHGHGVCNSNKNCHCEDGWAPPHCD---------- 674

  Fly   766 TEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFA---TLAVCYRRKTTTL 827
                 |......::...|....|...|...|....::..:|...|..|.   .|...:|:|.:.:
  Rat   675 -----TKGYGGSVDSGPTYNAKSTALRDGLLVFFFLIIPLVAAAFFLFIKRDELRKTFRKKRSQM 734

  Fly   828 K------------YDPPYSKKPIAKSYGGAATAPNHHSVEEVSLDGSSKLVYANQTG---FRDKG 877
            .            .||..|:.|...|.......||      ||.......|.....|   .|...
  Rat   735 SDGRNQANASRPPGDPSVSRPPGGPSVSRPPGGPN------VSRPPGGPNVSRPPGGPSVSRPPP 793

  Fly   878 IHGRRY 883
            :||.|:
  Rat   794 VHGNRF 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	28/106 (26%)
		Reprolysin	270..473	CDD:279729	75/212 (35%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	73/208 (35%)
		Disintegrin	488..562	CDD:278623	40/73 (55%)
		ACR	566..713	CDD:214743	52/146 (36%)
Adam9	NP_001014772.2	Pep_M12B_propep	44..163	CDD:396235	36/147 (24%)
		Reprolysin	212..406	CDD:396140	75/210 (36%)
		DISIN	423..498	CDD:214490	41/74 (55%)
		ACR	500..636	CDD:214743	51/146 (35%)
		EGF_2	650..673	CDD:400365	9/22 (41%)
		Pro-rich	732..>802	CDD:405837	15/74 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6784
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2908
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.970