DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam24

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_017455860.1	Gene:	Adam24 / 290774	RGDID:	1309066	Length:	740	Species:	Rattus norvegicus

Alignment Length:	755	Identity:	201/755 - (26%)
Similarity:	328/755 - (43%)	Gaps:	129/755 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 HKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTC-NGVSG 187
            |:..:.|:..:.|:|..:....|...|.|.:........|||.|.|.:.|.:.||..|| .|..|
  Rat    71 HRHIISLKSKNFLVSRQLPVFTYSDQGVLFEDRPFVQTDCYYLGFVDEDPESMAALTTCFGGFQG 135

  Fly   188 VIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEE 252
            ::.|.:.|:.|.|       |.|...||...              :::......|.....|:.:|
  Rat   136 ILQINDTTYKIKP-------KTPSFTFEHLL--------------YKIDSEETQLHPMRCGLTDE 179

  Fly   253 ILQAGVGRNKRDVREATK-----------YIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIAD 306
            .:...|...:.|.....:           ||:.|:::|...|..|..:| :.|:.|...:.|..:
  Rat   180 EIAGQVRLQENDKSTLMQSIYGSWWSHGLYIKLALVIDHEQFLYRKSNT-SLVLKDVFNIMNGIN 243

  Fly   307 LYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDTTQLLTGETFAG 370
            |...:::..|:::.:..|.:...:  ..:||...:..|..:.:.|. .|:..|...|....|| |
  Rat   244 LSLLSVDINVALLGLTIWTQRNPI--PVQDIYTLLPAFCLWKTMNFNSQMAYDIAHLFVNYTF-G 305

  Fly   371 GEAGMAVPETVCTPRAVGISVDVNVYEPHLLAG-TMAHMIGHNIGMGHDDGREECFCRDWHG-CI 433
            ...|:|...|||. :..|..||....:..|..| .:||.||||:||.||.    ..|....| |:
  Rat   306 DYFGIAFVGTVCN-KTFGCGVDRLFGDNFLTIGHIVAHEIGHNLGMPHDG----ILCSCGEGPCL 365

  Fly   434 MAQSIVGQENVQPYKFSECS---------KKDYIDALRTGHGLCLLNKPNEIEL--RRNCGNKVV 487
            |:.::...:     |.|.||         ||.           ||..:|:..::  .:.|||.||
  Rat   366 MSATMESSK-----KLSNCSYEFLWANIAKKS-----------CLQREPSSSDIFPMKICGNGVV 414

  Fly   488 EEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCD-QCRLRPKDYICRDSNNECDLPEYC 551
            ::.||||||: :.|..:..|...||.|||.|:||||.||: :|:::|...:||...|||||||:|
  Rat   415 DDGEECDCGS-QSCGRNSRCCLPTCILKSGAKCASGLCCNFKCQIQPSGTLCRTKENECDLPEWC 478

  Fly   552 DGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKG 616
            :|...:||.|.|.:.|:.|    .| :|||::..|.:....|:.::|.....|..:||::.|::|
  Rat   479 NGTSKECPEDTFVQAGTSC----LG-NGYCYEKRCNSHDDHCKRVFGEHAMKASDRCYKELNTRG 538

  Fly   617 SINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQ 681
            ...|:||. .|:.|::||..::.||.:||...:..|:   ::..|  |:...:..:..|.:|...
  Rat   539 DRFGNCGL-KNKGYVRCETSDILCGRIQCAKVKTFPI---LESHY--TVHWTRFNDASCWSTDYH 597

  Fly   682 VGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCD 746
            :|. ...:.|.:||||.||...:|:::.|      |::....::.....|:..|:|.|...|.||
  Rat   598 LGM-KIADLGDIKDGTNCGPQHVCISRKC------VNKPSWKSDCSPETCNMRGICNNKQHCHCD 655

  Fly   747 MGW----------GGN-DCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVI 800
            .||          ||: |..|             |.||:....::|..       .:...|.:.|
  Rat   656 FGWSPPLCVDNGTGGSIDSGS-------------PAPEDPNANKRKGI-------GKFIILLLPI 700

  Fly   801 ILTVIVKCVFISFATLAVCYRRKTTTLKYDPPYSKKPIAK 840
            |..|:|  :|:.|    ..:|....:|..|....|...||
  Rat   701 IFVVVV--LFLLF----YLFRTNRLSLGGDKQAKKGEEAK 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	25/89 (28%)
		Reprolysin	270..473	CDD:279729	55/225 (24%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	55/223 (25%)
		Disintegrin	488..562	CDD:278623	35/74 (47%)
		ACR	566..713	CDD:214743	40/146 (27%)
Adam24	XP_017455860.1	Pep_M12B_propep	42..160	CDD:396235	27/109 (25%)
		ZnMc_adamalysin_II_like	209..395	CDD:239797	54/210 (26%)
		DISIN	415..490	CDD:214490	36/75 (48%)
		ACR	492..628	CDD:214743	41/153 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339816
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2908
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900