DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and Adam28

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_001381600.1	Gene:	Adam28 / 290344	RGDID:	727820	Length:	774	Species:	Rattus norvegicus

Alignment Length:	811	Identity:	229/811 - (28%)
Similarity:	366/811 - (45%)	Gaps:	161/811 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIK-AFNHK-FR 127
            |:::||::|....|     ||...|:|                  |....|.|..| ..|.| ..
  Rat    30 YEVVYPIRLHLLHK-----RETKEPEP------------------KETFETELRYKMTVNGKVVE 71

  Fly   128 LDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHIG 192
            |.|:.|::||:|...:.:|:..|..|..:...::.|||.|.:.:...::|:...|.|:.|.....
  Rat    72 LYLKKNNKLLAPGYLETYYNSSGNKVTTSPQIMDSCYYQGHIINEKDSAASISMCQGLRGYFSQA 136

  Fly   193 NETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDS-WRLSRRTKHLSAGVAGVVEEILQA 256
            :|.:.|.|.....|.:..|.:|:...|.::..:|.|..|: |            :.|:.::::..
  Rat   137 DERYFIEPLSSEILDEQAHALFKDDPKEDQENSNCGVDDALW------------LQGLHQDVVLP 189

  Fly   257 G---VGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSV 318
            .   :..|...|:|..||||..:::|...|.|.| ....|:.....::||..::.:..|:..|::
  Rat   190 ATRLIKLNDGMVQEPKKYIEYYVVLDNGEFKKYN-KNLDEIRKRVHEMANYVNMLYNKLDAHVAL 253

  Fly   319 VYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIE-RDTTQLLTGETFAGGEAGMAVPETVC 382
            |.:|.| .::..|..:.|.:..:.||:.:...:|.:.: .|..||::...|:|...|:|...::|
  Rat   254 VGMEIW-TDEDKIKITPDANTTLENFSKWRGNDLLKRKHHDVAQLISSTDFSGSTVGLAFMSSMC 317

  Fly   383 TP-RAVGISVDVNVYEPHL-LAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQ 445
            :| .:|||..|.:.|  || :||||||.:|||:||.||  ...|.|.. ..|:|.||:   ....
  Rat   318 SPYHSVGIVQDHSNY--HLRVAGTMAHEMGHNLGMIHD--YLSCKCPS-EVCVMEQSL---RFHM 374

  Fly   446 PYKFSECSKKDYIDALRTGHGLCLLNK--PNEIELRRNCGNKVVEEDEECDCGTFEECALDQCCD 508
            |..||.||:.:|...|......||.|.  |::|.....|||:::|.:|:|||||.:||. ::|||
  Rat   375 PTDFSSCSRDNYRRFLEEKLSHCLFNSPLPSDIISTPVCGNQLLEMNEDCDCGTPKECT-NKCCD 438

  Fly   509 GITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLS 573
            ..|||:|:..|||.|.||::|:|:....:||.:.:||||||.|||:...||.|.|:.||.||
  Rat   439 AETCKIKAGFQCALGECCEKCQLKKPGVVCRAAKDECDLPEMCDGKSSHCPVDRFRVNGFPC--- 500

  Fly   574 KTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENV 638
            :.| .|||.:|.||||..||..:||.....|::.||:| |..||..|:|..:...| :.|:.::.
  Rat   501 QNG-HGYCLKGNCPTLQQQCMDMWGPETKVANKSCYKQ-NEGGSKYGYCHVENGTH-MPCKAKDA 562

  Fly   639 QCGTLQCKDG-------------------ERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGS 684
            .||.|.|:.|                   :.:.:|.|:|
  Rat   563 MCGKLFCEGGSGDLPWKGLTIAFLTCKLFDPEDINQGVD-------------------------- 601

  Fly   685 NSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGW 749
                   :|.:||.||:|.:|:|..||.:    ::|...||... :|..|.||.:..:|.|..||
  Rat   602 -------MVANGTKCGNNKVCINAECVDM----EKTYKSANCSS-KCKGHAVCDHELQCQCKEGW 654

  Fly   750 GGNDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFA 814
            ...||                        |...|.:      |:|.:..|:.....:      |.
  Rat   655 APPDC------------------------EDSATVF------RVSIMVGVLFPLAAI------FV 683

  Fly   815 TLAVCY-----RRKTTTLKYDPPYSKKPIAK 840
            .:|:..     |||...::..||.....:.|
  Rat   684 VIAIVIHHQSARRKQRRVQRLPPIKDAKLHK 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	28/108 (26%)
		Reprolysin	270..473	CDD:279729	66/207 (32%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	65/203 (32%)
		Disintegrin	488..562	CDD:278623	37/73 (51%)
		ACR	566..713	CDD:214743	46/165 (28%)
Adam28	NP_001381600.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020