DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and Adamdec1

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_017455116.1	Gene:	Adamdec1 / 290338	RGDID:	1309861	Length:	468	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	112/475 - (23%)
Similarity:	203/475 - (42%)	Gaps:	71/475 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 QIIYPVQLRHHEKMGISTREVSLPKPGQRPRPH---------DDSGFNRGRTKKHFHRTSLLIKA 121
            :|::|.:|...::.|:...:.......:|..|.         ::..|:..|||
  Rat    43 KIVHPKKLPISQRRGLENNQTESYAKEERYAPEVQYQIILNGEEIIFHLKRTK------------ 95

  Fly   122 FNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTCNGVS 186
                         .||.|:..:..|......:.....:::.|||.|.:::..|:.|:..||:|:.
  Rat    96 -------------HLLGPDYTEISYSPRREEMTRRSQNVKPCYYEGHIQNAKGSLASISTCDGLR 147

  Fly   187 GVIHIGNETFVIHPFYGGDLSKH---PHVIFEARTKANKGCANSGNLDSWRLSRRTKHL--SAGV 246
            |.....::.:.|.|....|..:|   ||      .....|..|..:.:. ::.|:..||  |..:
  Rat   148 GYFTHRDQKYQIMPLQSTDEGEHAVIPH------NWEEPGAVNYKHSEK-QIGRKRSHLRTSRSL 205

  Fly   247 AGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGS-TRAEVIHDAIQVANIADLYFR 310
            ....|:.||            ..|||...:::|.:.:....|: ||....  ..:|.|:.::.::
  Rat   206 KSPNEDSLQ------------GQKYIGLFLVLDNSYYKMYKGNVTRMRSF--VFEVLNLLNVIYK 256

  Fly   311 TLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGM 375
            |::.:||:|.:|.| .::..|....::....:||..:...||.|...:..|||:|..|..|..||
  Rat   257 TIDIQVSLVGMEIW-SDRDKIKVVPNLGATFTNFMRWHYSNLGQRIHNHAQLLSGAGFLHGRVGM 320

  Fly   376 AVPETVCTPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVG 440
            |...::||..:|.: ::........|...|:|.:||.:||.......:|   ....|:|.|.:
  Rat   321 AAANSLCTTSSVSV-IEAKRKNNVALVALMSHELGHALGMQDVPYYTKC---PSGSCVMNQYL-- 379

  Fly   441 QENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIE-LRRNCGNKVVEEDEECDCGTFEECALD 504
             .:..|..||..|:..:...|.:.:..|||..|:... ::..|||::::..|.||||:.|||. :
  Rat   380 -SSKFPKDFSTVSRSRFQGFLSSRNTRCLLLAPDPKNIIKPTCGNRLLDMGEGCDCGSPEECT-N 442

  Fly   505 QCCDGITCKLKSEAQCASGA 524
            .||:.:||:|||:..|...|
  Rat   443 LCCEPLTCRLKSQPDCREEA 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	23/109 (21%)
		Reprolysin	270..473	CDD:279729	52/203 (26%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	51/201 (25%)
		Disintegrin	488..562	CDD:278623	17/37 (46%)
		ACR	566..713	CDD:214743
Adamdec1	XP_017455116.1	Pep_M12B_propep	54..175	CDD:279848	25/145 (17%)
		Reprolysin	217..411	CDD:279729	52/203 (26%)
		ZnMc_adamalysin_II_like	217..408	CDD:239797	50/200 (25%)
		Disintegrin	427..>454	CDD:299186	13/27 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339810
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850