Protein Alignment mmd and Adam1a

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_742124.2
• Gene: Adam1a / 280668
• MGIID: 2429504
• Length: 791
• Species: Mus musculus
• Alignment Length: 793
• Identity: 221/793 - (27%)
• Similarity: 342/793 - (43%)
• Gaps: 115/793 - (14%)

  Fly    82 STREVSLPK--PGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQK 144
            |:.|..:|:  ||:..:  |..|           :.|.::.....|..|.||:.......|....
Mouse    73 SSYETVIPERLPGKGGK--DPGG-----------KVSYMLLMQGQKQLLHLEVKGHYPENNFPVY 124

  Fly   145 HYHVGGYLVDGNRHDI----EHCYYHGTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGD 205
            .|| .|.|    |.::    :.|:|.|.::..||:..:.:.|:|:.||:.....::.|.|...
Mouse   125 SYH-NGIL----RQEMPLLSQDCHYEGYMEGVPGSFVSVNICSGLRGVLIKEETSYGIEPMLS-- 182

  Fly   206 LSKH-PHVIFEARTKANKGCA-----NSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRD 264
             ||: .||::....:....|:     :.|:......||:...|..                 ..|
Mouse   183 -SKNFEHVLYTMEHQPVVSCSVTPKDSPGDTSHPPRSRKPDDLLV-----------------LTD 229

  Fly   265 VREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQA 329
            ....|||:|..::|:...| :..||...|.:...:.:..:|:.:.|.:||.|.:|.:|.|.:...
Mouse   230 WWSHTKYVEMFVVVNHQRF-QMWGSNINETVQAVMDIIALANSFTRGINTEVVLVGLEIWTEGDP 293

  Fly   330 VIDGSKDISKAISNFNDYTSRNLF-QIERDTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDV 393
             |:...|:...:.|||.:....|. ::..|...|:.|.. .|...|.|.....|:.. ...:|:.
Mouse   294 -IEVPVDLQTTLRNFNFWRQEKLVGRVRHDVAHLIVGHR-PGENEGQAFLRGACSGE-FAAAVEA 355

  Fly   394 NVYEPHLL-AGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDY 457
            ..:|..|| |..|||.:|||:|:.||  ...|.|...|.|:|.:.| |:::    .||.||...:
Mouse   356 FHHEDVLLFAALMAHELGHNLGIQHD--HPTCTCGPKHFCLMGEKI-GKDS----GFSNCSSDHF 413

  Fly   458 IDALRTGHGLCLLNKP-NEIELRR--NCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQ 519
            :..|....|.|||::| .:..:||  ||||.|||:.||||||:  :|....||.. ||.||..||
Mouse   414 LRFLHDHRGACLLDEPGRQSRMRRAANCGNGVVEDLEECDCGS--DCDSHPCCSP-TCTLKEGAQ 475

  Fly   520 CASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQG 584
            |:.|.||..|..:.|..:||.:.:.|||||||||...:||::.:.::|:.|....     ||..|
Mouse   476 CSEGLCCYNCTFKKKGSLCRPAEDVCDLPEYCDGSTQECPANSYMQDGTQCDRIY-----YCLGG 535

  Fly   585 YCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGR--DANEHYIKCEPENVQCGTLQCKD 647
            :|.....||..|:||...:|..:||...|:|.:..|:||.  .||..|..|..|:|.||.|.|.|
Mouse   536 WCKNPDKQCSRIYGYPARSAPEECYISVNTKANRFGNCGHPTSANFRYETCSDEDVFCGKLVCTD 600

  Fly   648 GERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVS 712
            ....|   .:..|:|  ::.:...|..|.:... ......|:.|.|:.||.|..|.:|:...|..
Mouse   601 VRYLP---KVKPLHS--LLQVPYGEDWCWSMDA-YNITDVPDDGDVQSGTFCAPNKVCMEYICTG 659

  Fly   713 LFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCS------SVVLLTTALPTE---- 767
              ..|.|..|.....   |..:|||.|...|.||.|:...|||      ||.......|.:
Mouse   660 --RGVLQYNCEPQEM---CHGNGVCNNFKHCHCDAGFAPPDCSSPGNGGSVDSGPVGKPADRHLS 719

  Fly   768 ----ALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLAVCYRRKTTTLK 828
                |..:|::  |||.:|.      ..::..|.:.|.|.|::.|:.:      :.|........
Mouse   720 LSFLAEESPDD--KMEDEEV------NLKVMVLVVPIFLVVLLCCLML------IAYLWSEVQEV 770

  Fly   829 YDPPYSKKPIAKS 841
            ..||.|.:..:.|
Mouse   771 VSPPSSSESSSSS 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	26/114 (23%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	58/202 (29%)
		Disintegrin	488..561	CDD:459709	35/72 (49%)
		ACR	566..713	CDD:214743	44/148 (30%)
Adam1a	NP_742124.2	Pep_M12B_propep	76..191	CDD:460254	32/135 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..220		3/18 (17%)
		Reprolysin	235..429	CDD:426256	59/204 (29%)
		DISIN	447..519	CDD:214490	35/74 (47%)
		ACR	521..657	CDD:214743	43/146 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	772..791		4/12 (33%)