DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mmd and Adam1b

DIOPT Version :9

Sequence 1:NP_001285311.1 Gene:mmd / 32561 FlyBaseID:FBgn0259110 Length:1484 Species:Drosophila melanogaster
Sequence 2:NP_742123.2 Gene:Adam1b / 280667 MGIID:2429506 Length:806 Species:Mus musculus


Alignment Length:914 Identity:225/914 - (24%)
Similarity:366/914 - (40%) Gaps:197/914 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 ESPVGEVERLLKEYRQNQELVRRIGGHYYQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDS 101
            :.|.|:|..:|....|.|.|...:.|||.:..:||...|:   ||..:|:               
Mouse    57 KDPGGKVSYMLLMQGQKQLLHLEVKGHYPENNFPVYSYHN---GILRQEM--------------- 103

  Fly   102 GFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYH 166
                                             .|||                      :.|:|.
Mouse   104 ---------------------------------PLLS----------------------QDCHYE 113

  Fly   167 GTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKH-PHVIFEARTKANKGCA----- 225
            |.::..||:..:.:.|:|:.||:.....::.|.|...   ||: .||::....:....|:     
Mouse   114 GYMEGVPGSFVSVNICSGLRGVLIKEETSYGIEPMLS---SKNFEHVLYTMEHQPVVSCSVTPKD 175

  Fly   226 NSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGST 290
            :.|:......||:...|..                 ..|....|||:|..::|:...| :..||.
Mouse   176 SPGDTSHPPRSRKPDDLLV-----------------LTDWWSHTKYVEMFVVVNHQRF-QMWGSN 222

  Fly   291 RAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLF-Q 354
            ..|.:...:.:..:|:.:.|.:||.|.:|.:|.|.:... |:...|:...:.|||.:....|. :
Mouse   223 INETVQAVMDIIALANSFTRGINTEVVLVGLEIWTEGDP-IEVPVDLQTTLRNFNFWRQEKLVGR 286

  Fly   355 IERDTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVYEPHLL-AGTMAHMIGHNIGMGHD 418
            :..|...|:.|.. .|...|.|.....|:.. ...:|:...:|..|| |..|||.:|||:|:.||
Mouse   287 VRHDVAHLIVGHR-PGENEGQAFLRGACSGE-FAAAVEAFHHEDVLLFAALMAHELGHNLGIQHD 349

  Fly   419 DGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKP-NEIELRR-- 480
              ...|.|...|.|:|.:.| |:::    .||.||...::..|....|:|||::| .:..:||  
Mouse   350 --HPTCTCGPKHFCLMGEKI-GKDS----GFSNCSSDHFLRFLHDHRGVCLLDEPGRQSRMRRAA 407

  Fly   481 NCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNEC 545
            ||||.|||:.|:||||:  :|...||||. .||||..:.|::..||.:|..:.:..:||.::..|
Mouse   408 NCGNGVVEDLEQCDCGS--DCDKSQCCDE-NCKLKGNSVCSTELCCFKCNFKKEGDVCRPADGPC 469

  Fly   546 DLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYE 610
            ||.|||:|....||||...::||.|     ..|..||.|.|...:.||..|:|:|..:|...||.
Mouse   470 DLEEYCNGTSAACPSDRKAQDGSKC-----HESFLCFNGQCMDPTFQCSRIFGHGSRSASDYCYT 529

  Fly   611 QFNSKGSINGHCGRDAN--EHYIKCEPENVQCGTLQCKD----GERQPVNDGIDQLYSRTIISIK 669
            ..||:|...|:||..:.  :.|.||..:||.||.|.|.:    .:.||.|         .::.:.
Mouse   530 SLNSRGDQFGNCGSSSQFPKKYTKCSDKNVMCGKLICTEVAFLPQIQPNN---------LLLQVP 585

  Fly   670 GQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEH 734
            ..|..|.:.:.....:|..|. .|||.|.||.:.:|.|..|....|.  ...|..:.|   |::|
Mouse   586 ETEDWCWSVAVFDMRDSLHEE-YVKDNTYCGKDKVCKNSICEDFTPF--SFPCSPSKQ---CNKH 644

  Fly   735 GVCTNTNRCFCDMGWGGNDCSS-----------VVLLTTALPTEALPTPENTIKMEKKETPYGTS 788
            |||.:...|.|..|:...||..           .|.|:    .::.|.|.:|          .:|
Mouse   645 GVCNDLGNCHCSFGFAPPDCKEEGTGGSVDSGPAVNLS----NDSSPGPNST----------QSS 695

  Fly   789 DQNRISTLTMVIILTVIVKCVFISFATLAVCYRRKTTTLKYDP-PYSKKPIAKSYGGAATAPNHH 852
            .:..|..|.::::..::|..:.:....:...|.:..|..:..| ...:.|..:........|...
Mouse   696 TEELILNLKLIVLAVILVLMILLIIICIISAYTKSETASEAGPSELEELPEGEKEEQEEVLPEEA 760

  Fly   853 SVEEVSLDGSSKLVYANQTGFRDKGIHGRRYTTCGEDDQSHAEKGILKKHGYGLVHGEQLKDKWG 917
            ..||..|:                  :|:         :...|:|.:::.|....:.|...:|..
Mouse   761 KGEEEELE------------------YGK---------EEAEEQGAVEEEGAEEANEEAAAEKKD 798

  Fly   918 DDNQ 921
            :|.:
Mouse   799 EDEE 802

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mmdNP_001285311.1 Pep_M12B_propep 106..213 CDD:279848 17/107 (16%)
Reprolysin 270..473 CDD:279729 59/204 (29%)
ZnMc_adamalysin_II_like 270..471 CDD:239797 58/202 (29%)
Disintegrin 488..562 CDD:278623 31/73 (42%)
ACR 566..713 CDD:214743 47/152 (31%)
Adam1bNP_742123.2 Pep_M12B_propep 63..158 CDD:279848 31/170 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..188 3/18 (17%)
Reprolysin 203..397 CDD:279729 59/204 (29%)
ZnMc_adamalysin_II_like 203..395 CDD:239797 58/202 (29%)
Disintegrin 415..485 CDD:278623 30/72 (42%)
ACR 489..625 CDD:214743 46/150 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 668..694 5/39 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 735..806 13/95 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167836140
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3607
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11905
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X50
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.850

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