Protein Alignment mmd and Adam1b

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_742123.2
• Gene: Adam1b / 280667
• MGIID: 2429506
• Length: 806
• Species: Mus musculus
• Alignment Length: 914
• Identity: 225/914 - (24%)
• Similarity: 366/914 - (40%)
• Gaps: 197/914 - (21%)

  Fly    37 ESPVGEVERLLKEYRQNQELVRRIGGHYYQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDS 101
            :.|.|:|..:|....|.|.|...:.|||.:..:||...|:   ||..:|:
Mouse    57 KDPGGKVSYMLLMQGQKQLLHLEVKGHYPENNFPVYSYHN---GILRQEM--------------- 103

  Fly   102 GFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYH 166
                                             .|||                      :.|:|.
Mouse   104 ---------------------------------PLLS----------------------QDCHYE 113

  Fly   167 GTVKDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKH-PHVIFEARTKANKGCA----- 225
            |.::..||:..:.:.|:|:.||:.....::.|.|...   ||: .||::....:....|:
Mouse   114 GYMEGVPGSFVSVNICSGLRGVLIKEETSYGIEPMLS---SKNFEHVLYTMEHQPVVSCSVTPKD 175

  Fly   226 NSGNLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGST 290
            :.|:......||:...|..                 ..|....|||:|..::|:...| :..||.
Mouse   176 SPGDTSHPPRSRKPDDLLV-----------------LTDWWSHTKYVEMFVVVNHQRF-QMWGSN 222

  Fly   291 RAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLF-Q 354
            ..|.:...:.:..:|:.:.|.:||.|.:|.:|.|.:... |:...|:...:.|||.:....|. :
Mouse   223 INETVQAVMDIIALANSFTRGINTEVVLVGLEIWTEGDP-IEVPVDLQTTLRNFNFWRQEKLVGR 286

  Fly   355 IERDTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVYEPHLL-AGTMAHMIGHNIGMGHD 418
            :..|...|:.|.. .|...|.|.....|:.. ...:|:...:|..|| |..|||.:|||:|:.||
Mouse   287 VRHDVAHLIVGHR-PGENEGQAFLRGACSGE-FAAAVEAFHHEDVLLFAALMAHELGHNLGIQHD 349

  Fly   419 DGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKP-NEIELRR-- 480
              ...|.|...|.|:|.:.| |:::    .||.||...::..|....|:|||::| .:..:||
Mouse   350 --HPTCTCGPKHFCLMGEKI-GKDS----GFSNCSSDHFLRFLHDHRGVCLLDEPGRQSRMRRAA 407

  Fly   481 NCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNEC 545
            ||||.|||:.|:||||:  :|...||||. .||||..:.|::..||.:|..:.:..:||.::..|
Mouse   408 NCGNGVVEDLEQCDCGS--DCDKSQCCDE-NCKLKGNSVCSTELCCFKCNFKKEGDVCRPADGPC 469

  Fly   546 DLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYE 610
            ||.|||:|....||||...::||.|     ..|..||.|.|...:.||..|:|:|..:|...||.
Mouse   470 DLEEYCNGTSAACPSDRKAQDGSKC-----HESFLCFNGQCMDPTFQCSRIFGHGSRSASDYCYT 529

  Fly   611 QFNSKGSINGHCGRDAN--EHYIKCEPENVQCGTLQCKD----GERQPVNDGIDQLYSRTIISIK 669
            ..||:|...|:||..:.  :.|.||..:||.||.|.|.:    .:.||.|         .::.:.
Mouse   530 SLNSRGDQFGNCGSSSQFPKKYTKCSDKNVMCGKLICTEVAFLPQIQPNN---------LLLQVP 585

  Fly   670 GQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEH 734
            ..|..|.:.:.....:|..|. .|||.|.||.:.:|.|..|....|.  ...|..:.|   |::|
Mouse   586 ETEDWCWSVAVFDMRDSLHEE-YVKDNTYCGKDKVCKNSICEDFTPF--SFPCSPSKQ---CNKH 644

  Fly   735 GVCTNTNRCFCDMGWGGNDCSS-----------VVLLTTALPTEALPTPENTIKMEKKETPYGTS 788
            |||.:...|.|..|:...||..           .|.|:    .::.|.|.:|          .:|
Mouse   645 GVCNDLGNCHCSFGFAPPDCKEEGTGGSVDSGPAVNLS----NDSSPGPNST----------QSS 695

  Fly   789 DQNRISTLTMVIILTVIVKCVFISFATLAVCYRRKTTTLKYDP-PYSKKPIAKSYGGAATAPNHH 852
            .:..|..|.::::..::|..:.:....:...|.:..|..:..| ...:.|..:........|...
Mouse   696 TEELILNLKLIVLAVILVLMILLIIICIISAYTKSETASEAGPSELEELPEGEKEEQEEVLPEEA 760

  Fly   853 SVEEVSLDGSSKLVYANQTGFRDKGIHGRRYTTCGEDDQSHAEKGILKKHGYGLVHGEQLKDKWG 917
            ..||..|:                  :|:         :...|:|.:::.|....:.|...:|..
Mouse   761 KGEEEELE------------------YGK---------EEAEEQGAVEEEGAEEANEEAAAEKKD 798

  Fly   918 DDNQ 921
            :|.:
Mouse   799 EDEE 802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	18/110 (16%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	58/202 (29%)
		Disintegrin	488..561	CDD:459709	30/72 (42%)
		ACR	566..713	CDD:214743	47/152 (31%)
Adam1b	NP_742123.2	Pep_M12B_propep	44..159	CDD:460254	34/177 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..188		3/18 (17%)
		Reprolysin	203..397	CDD:426256	59/204 (29%)
		Disintegrin	415..485	CDD:459709	30/72 (42%)
		ACR	489..625	CDD:214743	46/150 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..694		5/39 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	735..806		13/95 (14%)