DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and mde10

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_593472.1	Gene:	mde10 / 2542178	PomBaseID:	SPAC17A5.04c	Length:	512	Species:	Schizosaccharomyces pombe

Alignment Length:	560	Identity:	142/560 - (25%)
Similarity:	214/560 - (38%)	Gaps:	144/560 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 LSKHPHVIFEARTKANKGCANSGNLDSW---RL----SRRTKHLSAGVAGVVEEILQAGVGRNKR 263
            :|.:..:|. |.:..|.......||..|   ||    |:.|..|.........:.|..||..:..
pombe    13 VSSYAEIIL-AHSDENLLSRTKNNLSKWNENRLYDYGSKSTMSLPVSSLFPALQTLWIGVVADCS 76

  Fly   264 DVREATKYIETAIIVDKAMFDKRNG-STRAE-------VIHDAIQ------VANIADLYFRTLNT 314
            .|...|..:|    ..|.:|.:..| ||..|       .||..|.      .||:.|....:::.
pombe    77 YVTHFTSRME----AKKHIFQEFEGVSTLYEDSFNINVQIHSLILPSAHDCSANVVDRPEISMSP 137

  Fly   315 RVSV-VYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVP 378
            |:|: ..:|.:.|.:....|: ::.:|||..    .|..|..|...:.|.| .:......|::..
pombe   138 RISIEEKLEIFSKWKYESPGN-NVFEAISPH----ERESFPSEPQVSVLFT-SSVKRSPHGVSWF 196

  Fly   379 ETVCTPRAV-------GISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQ 436
            .|:|:...:       .:|| |:.|....|  .:||.|||.:|:.||..::.|.......|.::.
pombe   197 ATICSETHIENEWHVGPLSV-VSAYPNDRL--VVAHEIGHILGLIHDCNKKSCGDHSEACCPLSS 258

  Fly   437 S--------IVGQENVQPY---KFSECS--------KKDYIDALRTGHGLCLLNKPNEIELRR-- 480
            |        |:...|...|   :||:||        :|.|:       .|..|:||:|..:.|
pombe   259 SLCDAQELYIMNPSNSYTYANLRFSDCSILQLHSLVEKKYV-------SLSCLSKPSEKSVLRLG 316

  Fly   481 NCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQC--ASGACCDQCRLRPKDYICRDSNN 543
            .|||.:||:.||||||  |:|..:.||||.||||...:.|  ...|||.||..:....:||.|.|
pombe   317 TCGNGIVEDGEECDCG--EDCENNPCCDGKTCKLTKGSLCDDQQDACCYQCHFKNAGTLCRQSTN 379

  Fly   544 ECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQC 608
            .||.||:|.|...:||.|....:|..| ....|: |.|..|.|.:.|.||:.:..:
pombe   380 PCDKPEFCTGISSKCPVDENWDDGRIC-QDSLGM-GSCASGVCTSASRQCKKLTNF--------- 433

  Fly   609 YEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEF 673
                                       .::.|.:..||                   :|.:.::.
pombe   434 ---------------------------SSLSCHSDSCK-------------------VSCQNEDG 452

  Fly   674 ECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSL 713
            .|     .:.:..|      .|||.|...| |.|..||.:
pombe   453 TC-----FISAKDY------IDGTRCRGGL-CYNGVCVPI 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	1/6 (17%)
		Reprolysin	270..473	CDD:279729	56/243 (23%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	55/241 (23%)
		Disintegrin	488..562	CDD:278623	35/75 (47%)
		ACR	566..713	CDD:214743	25/146 (17%)
mde10	NP_593472.1	ZnMc	65..305	CDD:294052	60/259 (23%)
mde10	NP_593472.1	Disintegrin	324..397	CDD:278623	35/74 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	81	1.000	Domainoid score	I2314
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47294
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
TreeFam	0	0.000	Not matched by this tool.
	6	6.030