DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mmd and Adam34

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_665688.2	Gene:	Adam34 / 252866	MGIID:	2181992	Length:	714	Species:	Mus musculus

Alignment Length:	657	Identity:	194/657 - (29%)
Similarity:	297/657 - (45%)	Gaps:	75/657 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 SLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFH 180
            ||.|:...|...:..:.|  |:|.|.....|...|.|::........|||||.|.:.|.:....:
Mouse    64 SLNIEGQRHIITMKPKKN--LISRNFLLFTYSDQGDLLEEQPFVQNDCYYHGYVDEDPESLVIVN 126

  Fly   181 TCNG-VSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSA 244
            ||.| :.|.:.|...|:.|.|  ....|...|:.::.....::.......|....::::.| |..
Mouse   127 TCFGSLQGTLEINGTTYEIMP--KSTTSTFEHLAYKMDNGESEPSPMRCGLSEEEIAQQMK-LQE 188

  Fly   245 GVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYF 309
            ..|..:.:|.......:.|       :|:..:::|...:..||.:| ...|.|.:||.|..:.|:
Mouse   189 SNASTLLQIPYENWWTHHR-------FIDYFVVIDHNRYVHRNNNT-TTCIQDMLQVVNGINGYY 245

  Fly   310 RTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDTTQLLTGETFAGGEA 373
            ..:.|.|.:..:|.|.:|. :|:..::|.|.:..|.::....: .::..|...|....:: |...
Mouse   246 LQIQTDVVLTKLEVWSQNN-LINVEQEIRKVLGAFCNWKINAIGNRVRHDIIHLFVRRSY-GTYL 308

  Fly   374 GMAVPETVCTPRAVGISVDVNVYEPHLL---AGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMA 435
            |:|...|||    :.::..||.:....|   |..:||.:|||:||.||.  ..|.| ....||||
Mouse   309 GLANVGTVC----LTLNCAVNSFLSDSLSDMAFIIAHEMGHNLGMMHDG--SSCTC-GLSSCIMA 366

  Fly   436 QSIVGQENVQPY-----KFSECSKKDYIDALRTGHGLCLLNKPNEIE----LRRNCGNKVVEEDE 491
                      ||     |||.||.::....:....  ||.:.|:.::    :...|||.:|||.|
Mouse   367 ----------PYKSNSPKFSNCSYEEMFSVVTKRS--CLYDIPDALKTINLMPTMCGNNLVEEGE 419

  Fly   492 ECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIG 556
            |||||:.|.|..|.||.. .|.||..||||.|.||..|:......:||:..|||||||:|:|...
Mouse   420 ECDCGSTESCLQDPCCSS-DCVLKPGAQCAFGLCCKNCQFLKTGTVCREEKNECDLPEWCNGTSA 483

  Fly   557 QCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGH 621
            :||.||:|.:|.||    :| .|||::..|.....||..|:|.|..:||..||.:.|.:|...|:
Mouse   484 ECPGDVYKADGIPC----SG-EGYCYKMECHQRDEQCRKIFGNGSRSADEICYMEMNRRGDRFGN 543

  Fly   622 CGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSR----TIISIKGQEFECKATSGQV 682
            ||.|:: .|.:|...:|.||.:||         :.:.||..|    |:.........|..|....
Mouse   544 CGNDSS-MYRRCNLADVLCGRIQC---------ENVIQLPQRRNHETVHYTHFSNVTCWTTDYHF 598

  Fly   683 GSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDM 747
            |. :..:.|.|.|||.||.:.:|:::.|||      ::....|.....|...|||.|.:.|.|:.
Mouse   599 GI-TIDDVGAVSDGTTCGPDYLCVHRKCVS------KSVLVRNCTPQLCHMQGVCNNKDHCHCNN 656

  Fly   748 GWGGNDC 754
            .|...||
Mouse   657 TWEPPDC 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	28/97 (29%)
		Reprolysin	270..473	CDD:279729	56/211 (27%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	56/209 (27%)
		Disintegrin	488..562	CDD:278623	37/73 (51%)
		ACR	566..713	CDD:214743	47/150 (31%)
Adam34	NP_665688.2	Pep_M12B_propep	41..159	CDD:366707	28/98 (29%)
		ZnMc_adamalysin_II_like	207..395	CDD:239797	57/216 (26%)
		Disintegrin	416..488	CDD:365943	37/72 (51%)
		ACR	492..628	CDD:214743	48/157 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836150
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850