Protein Alignment mmd and Adam29

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_787953.2
• Gene: Adam29 / 244486
• MGIID: 2676326
• Length: 763
• Species: Mus musculus
• Alignment Length: 815
• Identity: 216/815 - (26%)
• Similarity: 354/815 - (43%)
• Gaps: 140/815 - (17%)

  Fly    63 HYY---QIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNH 124
            ||:   :::.|:::.  ||    ||.::||                       :..|..:|....
Mouse    35 HYHSSIEVVIPMKVT--EK----TRGMNLP-----------------------NWISYSLKLGGQ 70

  Fly   125 KFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTC-NGVSGV 188
            ::.:.:::.:..|:.::....|.....|::......:.|||.|.|:....:..:..:| .|..|:
Mouse    71 RYIIHMKIKNLFLTRHLPVFTYSDQDSLLEDYPFVQDDCYYQGYVEGDSESLVSLSSCFGGFHGL 135

  Fly   189 IHIGNETFVIHP--FYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVE 251
            :.|.|..:.|.|  |    ..|..|:::  :..:||..:...:|....::.:.:...:|     .
Mouse   136 LEINNIVYEIMPKKF----SRKFEHLVY--KVDSNKTESRGSSLMQDNITCQVELQKSG-----N 189

  Fly   252 EILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRV 316
            .||:..   :..|....||.:|..::|||.::|.....|  .::.|...|.||.|..:..:..::
Mouse   190 PILKQS---SFEDWWTHTKIVELVVVVDKTLYDHYGNYT--VMLSDLYSVINIVDTIYEVIGIKI 249

  Fly   317 SVVYIETWG-KNQAVIDGSKDISKAISNFNDYTSRN-LFQIERDTTQL-----LTGETFAGGEAG 374
            .:|.:|.|. ||..|||   |:||::..:..:.:.| |.:::.|.:.|     |.|.:..|...|
Mouse   250 LLVGVEVWNKKNLIVID---DVSKSLRLYCRWKASNFLHRLKHDVSHLFIYRHLRGLSGIGSTGG 311

  Fly   375 MAVPETVCTPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIV 439
            :..|:..|   ||...:|..:   :|.|..:||.:|||:||.||    |..|:    |..::.|:
Mouse   312 ICDPKRSC---AVVTFIDRTL---NLRAIGVAHHLGHNLGMKHD----EDICK----CSYSKCIM 362

  Fly   440 GQENVQPYKFSECSKKDYIDALRTGHGLCLLNK--PNEIELRRNCGNKVVEEDEECDCGTFEECA 502
            ..::....|||.|| .:|..:....:..||:..  ..:|..|..|||.|||:.|:||||:...|.
Mouse   363 HMDSPPIPKFSNCS-YNYFWSYTVKNTRCLMENMYTKDIFDRTRCGNGVVEDKEQCDCGSLRNCT 426

  Fly   503 LDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNG 567
            .|.||.. .|.|.:.:.||.|.||..|:..|...:||..:|.|||||:|:|...:||.|.:.::|
Mouse   427 NDLCCMS-NCTLSTGSSCAFGLCCKNCQFLPSGTLCRKRDNICDLPEWCNGTSHECPDDAYVEDG 490

  Fly   568 SPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIK 632
            .||     |:|.||::..|...:..|..|:|.....|...||.:.|:||...||||.. ...|||
Mouse   491 IPC-----GVSAYCYEKQCNDRNEHCRQIFGQNAKTASVHCYREINTKGDRFGHCGLQ-GPTYIK 549

  Fly   633 CEPENVQCGTLQCKDGERQPVNDGIDQLYS----RTIISIKGQEFECKATSGQVGSNSYPEHGLV 693
            |:..:..||.:||         |.:.|:.:    .||.....:...|..|....|: |..:.|.|
Mouse   550 CKSNDALCGRIQC---------DNVVQIPNMKDHSTIHFALVKNVSCWGTDYHTGT-SLTDIGDV 604

  Fly   694 KDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDC---- 754
            ||||.|..|.||:|:.||.: ..:|....||     .|:..|:|.|.:.|.|:..|...:|
Mouse   605 KDGTECEQNHICINRHCVHI-STLDSNCTPA-----FCNYRGICNNKHHCHCNFHWDPPNCMIRG 663

  Fly   755 --SSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLA 817
              .||        ...||...|    :||...|        ..|..:|||..::.|:      |.
Mouse   664 HGGSV--------DSGLPPKTN----KKKHFFY--------LLLLQLIILACLLSCL------LW 702

  Fly   818 VCYRRKTTTLK---YDPPYSKKPIAKSYGGAATAP 849
            :.:..|.:..|   ...|...|.::|.......:|
Mouse   703 LLFNIKGSKRKPQVQPTPVKTKKVSKKVPSQKPSP 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	20/112 (18%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	59/207 (29%)
		Disintegrin	488..561	CDD:459709	31/72 (43%)
		ACR	566..713	CDD:214743	50/150 (33%)
Adam29	NP_787953.2	Pep_M12B_propep	41..159	CDD:460254	27/150 (18%)
		ZnMc_adamalysin_II_like	205..391	CDD:239797	57/205 (28%)
		Disintegrin	412..484	CDD:459709	31/72 (43%)
		ACR	489..624	CDD:214743	50/150 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	712..763		5/26 (19%)