DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and Adam29

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	NP_787953.2	Gene:	Adam29 / 244486	MGIID:	2676326	Length:	763	Species:	Mus musculus

Alignment Length:	815	Identity:	216/815 - (26%)
Similarity:	354/815 - (43%)	Gaps:	140/815 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 HYY---QIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNH 124
            ||:   :::.|:::.  ||    ||.::||                       :..|..:|....
Mouse    35 HYHSSIEVVIPMKVT--EK----TRGMNLP-----------------------NWISYSLKLGGQ 70

  Fly   125 KFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFHTC-NGVSGV 188
            ::.:.:::.:..|:.::....|.....|::......:.|||.|.|:....:..:..:| .|..|:
Mouse    71 RYIIHMKIKNLFLTRHLPVFTYSDQDSLLEDYPFVQDDCYYQGYVEGDSESLVSLSSCFGGFHGL 135

  Fly   189 IHIGNETFVIHP--FYGGDLSKHPHVIFEARTKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVE 251
            :.|.|..:.|.|  |    ..|..|:::  :..:||..:...:|....::.:.:...:|     .
Mouse   136 LEINNIVYEIMPKKF----SRKFEHLVY--KVDSNKTESRGSSLMQDNITCQVELQKSG-----N 189

  Fly   252 EILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRV 316
            .||:..   :..|....||.:|..::|||.::|.....|  .::.|...|.||.|..:..:..::
Mouse   190 PILKQS---SFEDWWTHTKIVELVVVVDKTLYDHYGNYT--VMLSDLYSVINIVDTIYEVIGIKI 249

  Fly   317 SVVYIETWG-KNQAVIDGSKDISKAISNFNDYTSRN-LFQIERDTTQL-----LTGETFAGGEAG 374
            .:|.:|.|. ||..|||   |:||::..:..:.:.| |.:::.|.:.|     |.|.:..|...|
Mouse   250 LLVGVEVWNKKNLIVID---DVSKSLRLYCRWKASNFLHRLKHDVSHLFIYRHLRGLSGIGSTGG 311

  Fly   375 MAVPETVCTPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIV 439
            :..|:..|   ||...:|..:   :|.|..:||.:|||:||.||    |..|:    |..::.|:
Mouse   312 ICDPKRSC---AVVTFIDRTL---NLRAIGVAHHLGHNLGMKHD----EDICK----CSYSKCIM 362

  Fly   440 GQENVQPYKFSECSKKDYIDALRTGHGLCLLNK--PNEIELRRNCGNKVVEEDEECDCGTFEECA 502
            ..::....|||.|| .:|..:....:..||:..  ..:|..|..|||.|||:.|:||||:...|.
Mouse   363 HMDSPPIPKFSNCS-YNYFWSYTVKNTRCLMENMYTKDIFDRTRCGNGVVEDKEQCDCGSLRNCT 426

  Fly   503 LDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNG 567
            .|.||.. .|.|.:.:.||.|.||..|:..|...:||..:|.|||||:|:|...:||.|.:.::|
Mouse   427 NDLCCMS-NCTLSTGSSCAFGLCCKNCQFLPSGTLCRKRDNICDLPEWCNGTSHECPDDAYVEDG 490

  Fly   568 SPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIK 632
            .||     |:|.||::..|...:..|..|:|.....|...||.:.|:||...||||.. ...|||
Mouse   491 IPC-----GVSAYCYEKQCNDRNEHCRQIFGQNAKTASVHCYREINTKGDRFGHCGLQ-GPTYIK 549

  Fly   633 CEPENVQCGTLQCKDGERQPVNDGIDQLYS----RTIISIKGQEFECKATSGQVGSNSYPEHGLV 693
            |:..:..||.:||         |.:.|:.:    .||.....:...|..|....|: |..:.|.|
Mouse   550 CKSNDALCGRIQC---------DNVVQIPNMKDHSTIHFALVKNVSCWGTDYHTGT-SLTDIGDV 604

  Fly   694 KDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDC---- 754
            ||||.|..|.||:|:.||.: ..:|....||     .|:..|:|.|.:.|.|:..|...:|
Mouse   605 KDGTECEQNHICINRHCVHI-STLDSNCTPA-----FCNYRGICNNKHHCHCNFHWDPPNCMIRG 663

  Fly   755 --SSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATLA 817
              .||        ...||...|    :||...|        ..|..:|||..::.|:      |.
Mouse   664 HGGSV--------DSGLPPKTN----KKKHFFY--------LLLLQLIILACLLSCL------LW 702

  Fly   818 VCYRRKTTTLK---YDPPYSKKPIAKSYGGAATAP 849
            :.:..|.:..|   ...|...|.::|.......:|
Mouse   703 LLFNIKGSKRKPQVQPTPVKTKKVSKKVPSQKPSP 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	20/109 (18%)
		Reprolysin	270..473	CDD:279729	59/211 (28%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	59/207 (29%)
		Disintegrin	488..562	CDD:278623	31/73 (42%)
		ACR	566..713	CDD:214743	50/150 (33%)
Adam29	NP_787953.2	Pep_M12B_propep	58..158	CDD:279848	21/126 (17%)
		Reprolysin	205..391	CDD:279729	57/205 (28%)
		ZnMc_adamalysin_II_like	205..391	CDD:239797	57/205 (28%)
		Disintegrin	412..484	CDD:278623	31/72 (43%)
		ACR	489..624	CDD:214743	50/150 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..763		5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836157
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850